Family main features
CARMIL (Capping protein, Arp2/3, and myosin-I linker) is a multifunctional protein that plays a crucial role in the regulation of the actin cytoskeleton. The actin cytoskeleton is fundamental for various cellular processes, including cell motility, shape maintenance, and intracellular transport. CARMIL proteins are known for their interactions with capping protein (CP), Arp2/3 complex, and myosin-I, all of which are critical components of actin dynamics. These interactions enable CARMIL to coordinate and modulate actin assembly and disassembly, which is vital for cell movement and other dynamic cellular processes.
CARMIL proteins are highly conserved across eukaryotic species and are expressed in a wide variety of tissues, indicating their fundamental role in cellular physiology. The dysregulation of CARMIL has been associated with several pathological conditions, including cancer, where it may affect cell migration and metastasis.
CARMIL proteins possess several key structural domains:
CARMIL proteins are categorized into several subtypes based on their sequence homology and functional characteristics:
CARMIL proteins are integral to various cellular functions due to their role in actin cytoskeleton regulation:
Aberrant expression or mutation of CARMIL proteins can lead to various diseases:
CARMIL proteins are essential regulators of the actin cytoskeleton, influencing a wide range of cellular processes, including cell migration, immune responses, and intracellular transport. Their ability to interact with key actin-regulating proteins such as the capping protein, Arp2/3 complex, and myosin-I enables them to coordinate actin filament dynamics effectively. Dysregulation of CARMIL proteins is linked to various diseases, including cancer and immunodeficiencies, underscoring their importance in maintaining cellular and physiological homeostasis. Understanding the molecular mechanisms of CARMIL function and regulation offers potential therapeutic avenues for treating related diseases.
Capping protein, Arp2/3 and myosin-I linker protein 2 (CARMIL2)
LRRC16C, RLTPR,Leucine-rich repeat-containing protein 16C,F-actin-uncapping protein RLTPR
Capping protein, Arp2/3 and myosin-I linker protein 3 (CARMIL3)
CARMIL3,C14orf121, LRRC16B,Capping protein, Arp2/3 and myosin-I linker protein 3,Leucine-rich repeat-containing protein 16B
Capping protein, Arp2/3 and myosin-I linker protein 1 (CARMIL1)
F-actin-uncapping protein LRRC16A,CARMIL1,CARMIL,Leucine-rich repeat-containing protein 16A
En la tabla siguiente se muestra una comparativa de todos los reactivos disponibles en nuestro catálogo (Primary Antibodies, ELISA Kits) relacionados con CARMIL - Capping protein, Arp2/3 and myosin-I linker
Se muestran ordenados por categorías para poder comparar cómodamente sus características principales. Esta tabla, que contiene un enlace con la ficha de cada producto, es exportable a Excel.
Esta página contiene 18 reactivos de las marcas (Abbexa, FineTest) que se corresponden con tu busqueda
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provider | Code | reference | name | reactivity | sample type | assay type | test range | sensitivity | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | CARMIL1 | abx531316 | Human Leucine-rich repeat-containing protein 16A (CARMIL1) ELISA Kit | Human | Tissue homogenates,Cell lysates,Other biological fluids | 0.156 ng/ml - 10 ng/ml | 687.5 | 96 tests | Q5VZK9 | RUO | ||
Abbexa | CARMIL2 | abx531321 | Human Leucine-rich repeat-containing protein 16C (CARMIL2) ELISA Kit | Human | Tissue homogenates,Cell lysates,Other biological fluids | 0.156 ng/ml - 10 ng/ml | 687.5 | 96 tests | Q6F5E8 | RUO | ||
Abbexa | CARMIL3 | abx531318 | Human Leucine-rich repeat-containing protein 16B (CARMIL3) ELISA Kit | Human | Tissue homogenates,Cell lysates,Other biological fluids | 0.156 ng/ml - 10 ng/ml | 687.5 | 96 tests | Q8ND23 | RUO | ||
Abbexa | CARMIL1 | abx531317 | Mouse Leucine-rich repeat-containing protein 16A (CARMIL1) ELISA Kit | Mouse | Tissue homogenates,Cell lysates,Other biological fluids | 0.156 ng/ml - 10 ng/ml | 687.5 | 96 tests | Q6EDY6 | RUO | ||
Abbexa | CARMIL2 | abx531322 | Mouse Leucine-rich repeat-containing protein 16C (CARMIL2) ELISA Kit | Mouse | Tissue homogenates,Cell lysates,Other biological fluids | 0.156 ng/ml - 10 ng/ml | 687.5 | 96 tests | Q3V3V9 | RUO | ||
Abbexa | CARMIL3 | abx531319 | Mouse Leucine-rich repeat-containing protein 16B (CARMIL3) ELISA Kit | Mouse | Tissue homogenates,Cell lysates,Other biological fluids | 0.156 ng/ml - 10 ng/ml | 687.5 | 96 tests | Q3UFQ8 | RUO | ||
Abbexa | CARMIL3 | abx531320 | Rat Leucine-rich repeat-containing protein 16B (CARMIL3) ELISA Kit | Rat | Tissue homogenates,Cell lysates,Other biological fluids | 0.156 ng/ml - 10 ng/ml | 687.5 | 96 tests | Q5XHY1 | RUO |
provider | Code | reference | name | reactivity | clonality | host | immunogen target | isotype | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | CARMIL1 | abx346417 | F-actin-uncapping protein LRRC16A (CARMIL1) Antibody | Human | Polyclonal | Rabbit | F-actin-uncapping protein LRRC16A (CARMIL1) | Unconjugated | ELISA, IF/ICC | 162.5 | 20 µg | Q5VZK9 | RUO | |
Abbexa | CARMIL1 | abx346419 | F-actin-uncapping protein LRRC16A (CARMIL1) Antibody (FITC) | Human | Polyclonal | Rabbit | F-actin-uncapping protein LRRC16A (CARMIL1) | FITC | 162.5 | 20 µg | Q5VZK9 | RUO | ||
Abbexa | CARMIL1 | abx346418 | F-actin-uncapping protein LRRC16A (CARMIL1) Antibody (HRP) | Human | Polyclonal | Rabbit | F-actin-uncapping protein LRRC16A (CARMIL1) | HRP | ELISA | 162.5 | 20 µg | Q5VZK9 | RUO | |
Abbexa | CARMIL1 | abx346420 | F-actin-uncapping protein LRRC16A (CARMIL1) Antibody (Biotin) | Human | Polyclonal | Rabbit | F-actin-uncapping protein LRRC16A (CARMIL1) | Biotin | ELISA | 162.5 | 20 µg | Q5VZK9 | RUO | |
Abbexa | CARMIL1 | abx030121 | Leucine-Rich Repeat-Containing Protein 16A (LRRC16A) Antibody | Human | Polyclonal | Rabbit | Leucine-Rich Repeat-Containing Protein 16A (LRRC16A) | Unconjugated | ELISA, WB | 250 | 80 µl | Q5VZK9 | RUO | |
Abbexa | CARMIL2 | abx346583 | Capping protein, Arp2/3 and myosin-I linker protein 2 (CARMIL2) Antibody (HRP) | Human | Polyclonal | Rabbit | Capping protein, Arp2/3 and myosin-I linker protein 2 (CARMIL2) | HRP | ELISA | 250 | 50 µl | Q6F5E8 | RUO | |
Abbexa | CARMIL2 | abx346585 | Capping protein, Arp2/3 and myosin-I linker protein 2 (CARMIL2) Antibody (Biotin) | Human | Polyclonal | Rabbit | Capping protein, Arp2/3 and myosin-I linker protein 2 (CARMIL2) | Biotin | ELISA | 250 | 50 µl | Q6F5E8 | RUO | |
Abbexa | CARMIL2 | abx346584 | Capping protein, Arp2/3 and myosin-I linker protein 2 (CARMIL2) Antibody (FITC) | Human | Polyclonal | Rabbit | Capping protein, Arp2/3 and myosin-I linker protein 2 (CARMIL2) | FITC | 250 | 50 µl | Q6F5E8 | RUO | ||
Abbexa | CARMIL2 | abx346582 | Capping protein, Arp2/3 and myosin-I linker protein 2 (CARMIL2) Antibody | Human | Polyclonal | Rabbit | Capping protein, Arp2/3 and myosin-I linker protein 2 (CARMIL2) | Unconjugated | ELISA, WB, IP | 250 | 50 µl | Q6F5E8 | RUO | |
Abbexa | CARMIL2 | abx140388 | RLTPR / CARMIL2 Antibody | Human | Monoclonal | Mouse | RLTPR/CARMIL2 | Unconjugated | WB, FCM | 350 | 0.1 mg | Q6F5E8 | RUO | |
Abbexa | CARMIL3 | abx027739 | Leucine-Rich Repeat-Containing Protein 16B (LRRC16B) Antibody | Mouse | Polyclonal | Rabbit | Leucine-Rich Repeat-Containing Protein 16B (LRRC16B) | Unconjugated | ELISA, WB | 250 | 80 µl | Q8ND23 | RUO |
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