F-actin-uncapping protein LRRC16A (CARMIL1) Antibody
169€ (20 µg)
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Name
F-actin-uncapping protein LRRC16A (CARMIL1) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx346417
Tested Applications
ELISA, IF/ICC
Description
F-actin-uncapping protein LRRC16A (CARMIL1) Antibody is a Rabbit Polyclonal antibody for the detection of Human CARMIL1.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: F-actin-uncapping protein LRRC16A (CARMIL1) Immunogen: Recombinant Human F-actin-uncapping protein LRRC16A protein (1184-1295 AA) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purity | > 95% |
| Purification | Purified by Protein G chromatography. |
| Size 1 | 20 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Tested Applications | ELISA, IF/ICC |
| Buffer | 0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q5VZK9 |
| OMIM | 609593 |
| Alias | F-actin-uncapping protein LRRC16A,CARMIL1,CARMIL,Leucine-rich repeat-containing protein 16A |
| Background | Antibody anti-CARMIL1 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
CARMIL1 is a scaffolding protein that regulates actin dynamics by interacting with capping proteins, the Arp2/3 complex, and myosin-I. It plays a critical role in actin filament assembly and disassembly, essential for cell migration, adhesion, and membrane trafficking. CARMIL1 is required for proper lamellipodia and filopodia formation, contributing to cell shape and motility. Dysregulation of CARMIL1 has been linked to cancer metastasis and immune dysfunction, where altered actin remodeling affects cell invasion and signaling. It also participates in signaling pathways related to integrins and cytoskeletal reorganization, making it a target for therapeutic research in metastatic cancer and immune disorders.
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