Capping protein, Arp2/3 and myosin-I linker protein 2 (CARMIL2) Antibody
169€ (20 µl)
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Name
Capping protein, Arp2/3 and myosin-I linker protein 2 (CARMIL2) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx346582
Tested Applications
ELISA, WB, IP
Description
Capping protein, Arp2/3 and myosin-I linker protein 2 (CARMIL2) Antibody is a Rabbit Polyclonal antibody for the detection of Human CARMIL2.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Capping protein, Arp2/3 and myosin-I linker protein 2 (CARMIL2) Immunogen: Recombinant Human Capping protein, Arp2/3 and myosin-I linker protein 2 protein (1136-1290 AA) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purity | > 95% |
| Purification | Purified by Protein G chromatography. |
| Size 1 | 20 µl |
| Size 2 | 50 µl |
| Size 3 | 100 µl |
| Size 4 | 200 µl |
| Size 5 | 1 ml |
| Form | Liquid |
| Tested Applications | ELISA, WB, IP |
| Buffer | 0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q6F5E8 |
| Alias | LRRC16C, RLTPR,Leucine-rich repeat-containing protein 16C,F-actin-uncapping protein RLTPR |
| Background | Antibody anti-CARMIL2 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
CARMIL2, also known as RLTPR, regulates actin cytoskeleton dynamics and is involved in T cell activation and immune synapse formation. It functions by interacting with capping proteins to modulate actin polymerization, enabling proper immune cell signaling and migration. CARMIL2 is crucial for T cell receptor signaling and NF-kB activation, making it essential for adaptive immune responses. Mutations or dysregulation of CARMIL2 are associated with immune deficiencies and autoimmune diseases. Research into CARMIL2 focuses on its role in cytoskeletal remodeling and immune synapse assembly, with potential therapeutic implications in immunodeficiency disorders.
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