RLTPR / CARMIL2 Antibody
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Descripción del producto
RLTPR/CARMIL2 Antibody is a Mouse Monoclonal against RLTPR/CARMIL2. This gene encodes a member of the CARMIL (capping protein, Arp2/3, myosin-I linker) family of proteins. The encoded protein interacts with and negatively regulates the heterodimeric capping protein and promotes cell migration. Reduced expression of this gene has been observed in human psoriasis patients. Mutations in this gene cause a human immunodeficiency syndrome characterized by smooth muscle tumors and impaired T-cell function. [provided by RefSeq, May 2017]. RLTPR / CARMIL2 is a cytosolic protein, which with high affinity binds CAPZA2 (capping protein muscle actin Z-line alpha 2) and decreases CAPZA2 affinity for actin barbed ends.
Documents del producto
Especificaciones del producto
| Availability | Shipped within 5-12 working days. |
| Background | Antibody anti-CARMIL2 |
| Buffer | PBS solution with 15 mM sodium azide. |
| Category | Primary Antibodies |
| Clonality | Monoclonal |
| Clone ID | A264 |
| Conjugation | Unconjugated |
| Dry Ice | No |
| Gene ID | 146206 |
| Host | Mouse |
| Immunogen Target | RLTPR/CARMIL2 |
| Isotype | IgG1 Kappa |
| Name | RLTPR / CARMIL2 Antibody |
| Note | Concentration: 1 mg/ml - |
| Price | 364 |
| Provider | Abbexa |
| Purification | Purified from cell culture supernatant by Protein A affinity chromatography. |
| Purity | > 95% (SDS-PAGE) |
| Reactivity | Human, Mouse |
| Recommended Dilution | FCM: 1-4 µg/ml. Optimal dilutions/concentrations should be determined by the end user. |
| Reference | abx140388 |
| Size 1 | 0.1 mg |
| Status | RUO |
| Storage | Store at 2-8°C. Do not freeze. |
| Tested Applications | WB, FCM |
| UniProt ID | Q6F5E8 |
Descripcion del producto en español
Background en español
CARMIL2, also known as RLTPR, regulates actin cytoskeleton dynamics and is involved in T cell activation and immune synapse formation. It functions by interacting with capping proteins to modulate actin polymerization, enabling proper immune cell signaling and migration. CARMIL2 is crucial for T cell receptor signaling and NF-kB activation, making it essential for adaptive immune responses. Mutations or dysregulation of CARMIL2 are associated with immune deficiencies and autoimmune diseases. Research into CARMIL2 focuses on its role in cytoskeletal remodeling and immune synapse assembly, with potential therapeutic implications in immunodeficiency disorders.
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