RLTPR / CARMIL2 Antibody

Name: RLTPR / CARMIL2 Antibody
Brand: Abbexa
SKU: abx140388
Price: 350 EUR
Availability: OnlineOnly

Este producto es parte de CARMIL - Capping protein, Arp2/3 and myosin-I linker

Pida mas información

935106861

info@markelab.com

Precio

350€ (0.1 mg)

Antibody anti-CARMIL2

proveedor

Abbexa

reference

abx140388

Tested Applications

WB, FCM

reactivity

Human, Mouse

status

RUO

clonality

Monoclonal

Descripción

RLTPR/CARMIL2 Antibody is a Mouse Monoclonal against RLTPR/CARMIL2. This gene encodes a member of the CARMIL (capping protein, Arp2/3, myosin-I linker) family of proteins. The encoded protein interacts with and negatively regulates the heterodimeric capping protein and promotes cell migration. Reduced expression of this gene has been observed in human psoriasis patients. Mutations in this gene cause a human immunodeficiency syndrome characterized by smooth muscle tumors and impaired T-cell function. [provided by RefSeq, May 2017]. RLTPR / CARMIL2 is a cytosolic protein, which with high affinity binds CAPZA2 (capping protein muscle actin Z-line alpha 2) and decreases CAPZA2 affinity for actin barbed ends.

Background

CARMIL2, also known as RLTPR, regulates actin cytoskeleton dynamics and is involved in T cell activation and immune synapse formation. It functions by interacting with capping proteins to modulate actin polymerization, enabling proper immune cell signaling and migration. CARMIL2 is crucial for T cell receptor signaling and NF-kB activation, making it essential for adaptive immune responses. Mutations or dysregulation of CARMIL2 are associated with immune deficiencies and autoimmune diseases. Research into CARMIL2 focuses on its role in cytoskeletal remodeling and immune synapse assembly, with potential therapeutic implications in immunodeficiency disorders.

Características del producto

clonality

Monoclonal

reactivity

Human, Mouse

immunogen target

RLTPR/CARMIL2

host

Mouse

conjugation

Unconjugated

tested applications

WB, FCM

purity

> 95% (SDS-PAGE)

purification

Purified from cell culture supernatant by Protein A affinity chromatography.

buffer

PBS solution with 15 mM sodium azide.

size 1

0.1 mg

storage

Store at 2-8°C. Do not freeze.

or code

CARMIL2

dry ice

availability

Shipped within 5-12 working days.

uniprot id

https://www.uniprot.org/uniprotkb/Q6F5E8

gene id

https://www.ncbi.nlm.nih.gov/gene/146206

note

This product is for research use only.

Quizá le pueda interesar