RLTPR / CARMIL2 Antibody
364€ (0.1 mg)
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Name
RLTPR / CARMIL2 Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx140388
Tested Applications
WB, FCM
Description
RLTPR/CARMIL2 Antibody is a Mouse Monoclonal against RLTPR/CARMIL2. This gene encodes a member of the CARMIL (capping protein, Arp2/3, myosin-I linker) family of proteins. The encoded protein interacts with and negatively regulates the heterodimeric capping protein and promotes cell migration. Reduced expression of this gene has been observed in human psoriasis patients. Mutations in this gene cause a human immunodeficiency syndrome characterized by smooth muscle tumors and impaired T-cell function. [provided by RefSeq, May 2017]. RLTPR / CARMIL2 is a cytosolic protein, which with high affinity binds CAPZA2 (capping protein muscle actin Z-line alpha 2) and decreases CAPZA2 affinity for actin barbed ends.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: RLTPR/CARMIL2 Immunogen: Murine Rltpr (amino acids 1147-1397). |
| Host | Mouse |
| Reactivity | Human, Mouse |
| Assay Type | Concentration: 1 mg/ml |
| Recommended Dilution | FCM: 1-4 µg/ml. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Isotype | IgG1 Kappa |
| Clone ID | A264 |
| Purity | > 95% (SDS-PAGE) |
| Purification | Purified from cell culture supernatant by Protein A affinity chromatography. |
| Size 1 | 0.1 mg |
| Tested Applications | WB, FCM |
| Buffer | PBS solution with 15 mM sodium azide. |
| Availability | Shipped within 5-12 working days. |
| Storage | Store at 2-8°C. Do not freeze. |
| Dry Ice | No |
| UniProt ID | Q6F5E8 |
| Gene ID | 146206 |
| Background | Antibody anti-CARMIL2 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
CARMIL2, also known as RLTPR, regulates actin cytoskeleton dynamics and is involved in T cell activation and immune synapse formation. It functions by interacting with capping proteins to modulate actin polymerization, enabling proper immune cell signaling and migration. CARMIL2 is crucial for T cell receptor signaling and NF-kB activation, making it essential for adaptive immune responses. Mutations or dysregulation of CARMIL2 are associated with immune deficiencies and autoimmune diseases. Research into CARMIL2 focuses on its role in cytoskeletal remodeling and immune synapse assembly, with potential therapeutic implications in immunodeficiency disorders.
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