RLTPR / CARMIL2 Antibody
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Description
RLTPR/CARMIL2 Antibody is a Mouse Monoclonal against RLTPR/CARMIL2. This gene encodes a member of the CARMIL (capping protein, Arp2/3, myosin-I linker) family of proteins. The encoded protein interacts with and negatively regulates the heterodimeric capping protein and promotes cell migration. Reduced expression of this gene has been observed in human psoriasis patients. Mutations in this gene cause a human immunodeficiency syndrome characterized by smooth muscle tumors and impaired T-cell function. [provided by RefSeq, May 2017]. RLTPR / CARMIL2 is a cytosolic protein, which with high affinity binds CAPZA2 (capping protein muscle actin Z-line alpha 2) and decreases CAPZA2 affinity for actin barbed ends.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | RLTPR/CARMIL2 |
| Host | Mouse |
| Reactivity | Human, Mouse |
| Recommended Dilution | FCM: 1-4 µg/ml. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Isotype | IgG1 Kappa |
| Clone ID | A264 |
| Purity | > 95% (SDS-PAGE) |
| Purification | Purified from cell culture supernatant by Protein A affinity chromatography. |
| Size 1 | 0.1 mg |
| Tested Applications | WB, FCM |
| Buffer | PBS solution with 15 mM sodium azide. |
| Availability | Shipped within 5-12 working days. |
| Storage | Store at 2-8°C. Do not freeze. |
| Dry Ice | No |
| UniProt ID | Q6F5E8 |
| Gene ID | 146206 |
| Background | Antibody anti-CARMIL2 |
| Status | RUO |
| Note | Concentration: 1 mg/ml - |
Descripción
CARMIL2, also known as RLTPR, regulates actin cytoskeleton dynamics and is involved in T cell activation and immune synapse formation. It functions by interacting with capping proteins to modulate actin polymerization, enabling proper immune cell signaling and migration. CARMIL2 is crucial for T cell receptor signaling and NF-kB activation, making it essential for adaptive immune responses. Mutations or dysregulation of CARMIL2 are associated with immune deficiencies and autoimmune diseases. Research into CARMIL2 focuses on its role in cytoskeletal remodeling and immune synapse assembly, with potential therapeutic implications in immunodeficiency disorders.
Related Products
RLTPR / CARMIL2 Antibody
RLTPR/CARMIL2 Antibody is a Mouse Monoclonal against RLTPR/CARMIL2. This gene encodes a member of the CARMIL (capping protein, Arp2/3, myosin-I linker) family of proteins. The encoded protein interacts with and negatively regulates the heterodimeric capping protein and promotes cell migration. Reduced expression of this gene has been observed in human psoriasis patients. Mutations in this gene cause a human immunodeficiency syndrome characterized by smooth muscle tumors and impaired T-cell function. [provided by RefSeq, May 2017]. RLTPR / CARMIL2 is a cytosolic protein, which with high affinity binds CAPZA2 (capping protein muscle actin Z-line alpha 2) and decreases CAPZA2 affinity for actin barbed ends.
Ver Producto
RLTPR / CARMIL2 Antibody
RLTPR/CARMIL2 Antibody is a Mouse Monoclonal against RLTPR/CARMIL2.
Ver ProductoCapping protein, Arp2/3 and myosin-I linker protein 2 (CARMIL2) Antibody
Capping protein, Arp2/3 and myosin-I linker protein 2 (CARMIL2) Antibody is a Rabbit Polyclonal antibody for the detection of Human CARMIL2.
Ver Producto