Capping protein, Arp2/3 and myosin-I linker protein 2 (CARMIL2) Antibody (Biotin)
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Descripción del producto
Capping protein, Arp2/3 and myosin-I linker protein 2 (CARMIL2) Antibody (Biotin) is a Rabbit Polyclonal antibody conjugated to Biotin for the detection of Human CARMIL2.
Documents del producto
Especificaciones del producto
| Alias | LRRC16C, RLTPR,Leucine-rich repeat-containing protein 16C,F-actin-uncapping protein RLTPR |
| Availability | Shipped within 5-10 working days. |
| Background | Antibody anti-CARMIL2 |
| Buffer | 0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% glycerol. |
| Category | Primary Antibodies |
| Clonality | Polyclonal |
| Conjugation | Biotin |
| Dry Ice | No |
| Form | Liquid |
| Host | Rabbit |
| Immunogen Target | Capping protein, Arp2/3 and myosin-I linker protein 2 (CARMIL2) |
| Isotype | IgG |
| Name | Capping protein, Arp2/3 and myosin-I linker protein 2 (CARMIL2) Antibody (Biotin) |
| Price | 260 |
| Provider | Abbexa |
| Purification | Purified by Protein G chromatography. |
| Purity | > 95% |
| Reactivity | Human |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Reference | abx346585 |
| Size 1 | 50 µl |
| Size 2 | 100 µl |
| Size 3 | 200 µl |
| Size 4 | 1 ml |
| Status | RUO |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Tested Applications | ELISA |
| UniProt ID | Q6F5E8 |
Descripcion del producto en español
Background en español
CARMIL2, also known as RLTPR, regulates actin cytoskeleton dynamics and is involved in T cell activation and immune synapse formation. It functions by interacting with capping proteins to modulate actin polymerization, enabling proper immune cell signaling and migration. CARMIL2 is crucial for T cell receptor signaling and NF-kB activation, making it essential for adaptive immune responses. Mutations or dysregulation of CARMIL2 are associated with immune deficiencies and autoimmune diseases. Research into CARMIL2 focuses on its role in cytoskeletal remodeling and immune synapse assembly, with potential therapeutic implications in immunodeficiency disorders.
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