Leucine-Rich Repeat-Containing Protein 16A (LRRC16A) Antibody

Name: Leucine-Rich Repeat-Containing Protein 16A (LRRC16A) Antibody
Brand: Abbexa
SKU: abx030121
Price: 250 EUR
Availability: OnlineOnly

Este producto es parte de CARMIL - Capping protein, Arp2/3 and myosin-I linker

Pida mas información

935106861

info@markelab.com

Precio

250€ (80 µl)

Antibody anti-CARMIL1

proveedor

Abbexa

reference

abx030121

Tested Applications

ELISA, WB

reactivity

Human, Mouse

status

RUO

clonality

Polyclonal

Descripción

LRRC16A binds CAPZA2 with high affinity and significantly decreases CAPZA2 affinity for actin barbed ends. Increases the rate of elongation from seeds in the presence of CAPZA2, however, seems unable to nucleate filaments. Rapidly uncaps barbed ends capped by CAPZA2 and enhances barbed-end actin polymerization (By similarity).

Background

CARMIL1 is a scaffolding protein that regulates actin dynamics by interacting with capping proteins, the Arp2/3 complex, and myosin-I. It plays a critical role in actin filament assembly and disassembly, essential for cell migration, adhesion, and membrane trafficking. CARMIL1 is required for proper lamellipodia and filopodia formation, contributing to cell shape and motility. Dysregulation of CARMIL1 has been linked to cancer metastasis and immune dysfunction, where altered actin remodeling affects cell invasion and signaling. It also participates in signaling pathways related to integrins and cytoskeletal reorganization, making it a target for therapeutic research in metastatic cancer and immune disorders.

Características del producto

clonality

Polyclonal

reactivity

Human, Mouse

immunogen target

Leucine-Rich Repeat-Containing Protein 16A (LRRC16A)

host

Rabbit

conjugation

Unconjugated

form

Liquid

tested applications

ELISA, WB

purification

Purified through a protein A column, followed by peptide affinity purification.

buffer

PBS containing 0.09% sodium azide.

size 1

80 µl

size 2

400 µl

storage

Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.

or code

CARMIL1

dry ice

availability

Shipped within 5-10 working days.

alias

F-actin-uncapping protein LRRC16A,CARMIL1,CARMIL,Leucine-rich repeat-containing protein 16A

uniprot id

https://www.uniprot.org/uniprotkb/Q5VZK9

note

This product is for research use only.

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