Leucine-Rich Repeat-Containing Protein 16A (LRRC16A) Antibody
292.5€ (80 µl)
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935106861
info@markelab.com
name
Leucine-Rich Repeat-Containing Protein 16A (LRRC16A) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx030121
tested applications
ELISA, WB
Description
LRRC16A binds CAPZA2 with high affinity and significantly decreases CAPZA2 affinity for actin barbed ends. Increases the rate of elongation from seeds in the presence of CAPZA2, however, seems unable to nucleate filaments. Rapidly uncaps barbed ends capped by CAPZA2 and enhances barbed-end actin polymerization (By similarity).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Leucine-Rich Repeat-Containing Protein 16A (LRRC16A) |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Recommended Dilution | WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Size 1 | 80 µl |
| Size 2 | 400 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q5VZK9 |
| Alias | F-actin-uncapping protein LRRC16A,CARMIL1,CARMIL,Leucine-rich repeat-containing protein 16A |
| Background | Antibody anti-CARMIL1 |
| Status | RUO |
Descripción
CARMIL1 is a scaffolding protein that regulates actin dynamics by interacting with capping proteins, the Arp2/3 complex, and myosin-I. It plays a critical role in actin filament assembly and disassembly, essential for cell migration, adhesion, and membrane trafficking. CARMIL1 is required for proper lamellipodia and filopodia formation, contributing to cell shape and motility. Dysregulation of CARMIL1 has been linked to cancer metastasis and immune dysfunction, where altered actin remodeling affects cell invasion and signaling. It also participates in signaling pathways related to integrins and cytoskeletal reorganization, making it a target for therapeutic research in metastatic cancer and immune disorders.
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