ANXA2 - Annexin A2 (receptor) | Elisa - Clia - Antibody - Protein

Family main features


Background:

Annexin A2 or ANXA2, is a multifunctional protein that plays diverse roles in cellular processes. ANXA2 is a member of the annexin family, known for its calcium-dependent phospholipid-binding properties. ANXA2 is involved in membrane organization and dynamics. It can bind to phospholipids in the cell membrane, affecting its structure and function.ANXA2 has roles in endocytosis, the process by which cells absorb molecules from the external environment, and exocytosis, the release of molecules from cells. ANXA2 plays a role in the regulation of fibrinolysis, It interacts with plasminogen and tissue plasminogen activator (tPA) to promote the conversion of plasminogen to plasmin, an enzyme that degrades fibrin.ANXA2 also acts as a receptor for several proteins. ANXA2 forms a complex with tPA, aiding in the conversion of plasminogen to plasmin, which is crucial for fibrinolysis. S100A10 (P11) forms a heterotetrameric complex with ANXA2, which has implications in processes such as membrane organization and exocytosis.ANXA2 is expressed in various tissues, including the brain, heart, kidney, and liver. Its expression pattern suggests roles in these tissues, particularly in processes related to membrane dynamics and cellular signaling.


Protein Structure:

  • Core Domain: ANXA2 contains a conserved core domain made up of four annexin repeats. These repeats are responsible for calcium-dependent phospholipid binding.
  • N-terminal Domain: ANXA2 has a unique N-terminal domain that facilitates its interactions with other proteins and post-translational modifications such as phosphorylation and acetylation. This domain is critical for its diverse functional roles.


Classification and Subtypes:

ANXA2 belongs to the annexin family, which includes several other proteins (e.g., ANXA1, ANXA3, ANXA5). While there are no subtypes of ANXA2, it can exist in different functional forms:

  • Monomeric ANXA2: Functions independently in various cellular processes.
  • Heterotetrameric Form: ANXA2 often forms a complex with S100A10 (p11), creating a heterotetramer that has distinct functions, particularly in membrane dynamics and cellular signaling.


Function and Biological Significance:

  • Membrane Dynamics: ANXA2 plays a critical role in membrane-related processes such as endocytosis, exocytosis, and membrane repair. It helps in the organization of membrane domains and the formation of lipid rafts.
  • Cytoskeletal Interactions: ANXA2 interacts with the actin cytoskeleton, contributing to cell shape, motility, and adhesion.
  • Cellular Signaling: ANXA2 is involved in various signaling pathways, including those regulating cell growth and apoptosis. It also participates in the assembly of signaling complexes at the plasma membrane.
  • Angiogenesis and Coagulation: ANXA2 is crucial for angiogenesis (the formation of new blood vessels) and the regulation of coagulation, promoting plasminogen activation and fibrinolysis.


Interactions:

  • Protein-Protein Interactions: ANXA2 interacts with several proteins, including S100A10, actin, and various signaling molecules. The ANXA2-S100A10 complex is particularly important for membrane dynamics and signal transduction.
  • Phospholipids: ANXA2 binds to phospholipids in a calcium-dependent manner, which is essential for its role in membrane organization and vesicle trafficking.


Clinical Issues:

  • Cancer: ANXA2 is implicated in various cancers, including breast, lung, and colorectal cancers. It is often overexpressed in tumors and is associated with increased cell proliferation, invasion, and metastasis. ANXA2's role in angiogenesis also supports tumor growth and vascularization.
  • Inflammatory Diseases: ANXA2 is involved in inflammatory responses and has been linked to conditions such as rheumatoid arthritis and inflammatory bowel disease. Its regulation of plasminogen activation and fibrinolysis can influence inflammation and tissue remodeling.
  • Vascular Diseases: Given its role in angiogenesis and coagulation, ANXA2 is associated with vascular diseases. Abnormal ANXA2 function or expression can contribute to atherosclerosis, thrombosis, and other vascular disorders.


Summary:

Annexin A2 (ANXA2) is a multifunctional protein that plays critical roles in membrane dynamics, cytoskeletal interactions, and cellular signaling. Its ability to bind phospholipids in a calcium-dependent manner and form complexes with other proteins, such as S100A10, enables it to participate in various physiological processes, including angiogenesis and coagulation. ANXA2 is implicated in several clinical conditions, particularly cancer and inflammatory diseases, where its altered expression and function can contribute to disease progression. Understanding ANXA2's mechanisms and interactions is essential for developing therapeutic strategies targeting its activity in pathological conditions.



ANXA2 Recommended name:

Annexin A2 (ANXA2)

Aliases for ANXA2

ANXA2,ANX2,ANX2L4,CAL1H

ANXA2P2 Recommended name:

Putative annexin A2 (ANXA2P2)

Aliases for ANXA2P2

ANXA2P2,ANX2L2,ANX2P2,LPC2B

ANXA2R Recommended name:

Annexin-2 receptor (ANXA2R)

Aliases for ANXA2R

ANXA2R,AX2R,C5orf39

En la tabla siguiente se muestra una comparativa de todos los reactivos disponibles en nuestro catálogo (Proteins and Peptides, ELISA Kits, Primary Antibodies, CLIA Kits) relacionados con ANXA2 - Annexin A2 (receptor)

Se muestran ordenados por categorías para poder comparar cómodamente sus características principales. Esta tabla, que contiene un enlace con la ficha de cada producto, es exportable a Excel.

Esta página contiene 62 reactivos de las marcas (Abbexa, FineTest) que se corresponden con tu busqueda

Contacta con nosotros en info@markelab.com, si necesitas mas informacion o alguna aclaracion. Te garantizamos respuesta en menos de 24 h.

immunoassays

providerCodereferencenamereactivitysample typeassay typetest rangesensitivitypricesize 1uniprot idstatus
AbbexaANXA2abx356138Chicken Annexin A2 (ANXA2) ELISA KitChickenSerum, plasma and other biological fluids.Sandwich0.625 ng/ml - 40 ng/ml0.38 ng/ml68996 testsRUO
AbbexaANXA2abx518902Cow Annexin A2 (ANXA2) ELISA KitCowSerum, plasma, tissue homogenates, cell lysates and other biological fluids.0.156 ng/ml - 10 ng/ml71596 testsP04272RUO
AbbexaANXA2abx518904Dog Annexin A2 (ANXA2) ELISA KitDogSerum, plasma and other biological fluids.0.156 ng/ml - 10 ng/ml71596 testsQ6TEQ7RUO
FineTestANXA2EH2012Human ANXA2(Annexin A2) ELISA KithumanSerum,Plasma,Tissue homogenates,Other biological fluidsSandwich ELISA, Double Antibody0.625-40ng/ml96TP07355RUO
AbbexaANXA2abx150668Human Annexin A2 (ANXA2) ELISA KitHumanSerum, plasma, tissue homogenates, cell lysates, cell culture supernatants and other biological fluids.Sandwich0.156 ng/ml - 10 ng/ml< 0.07 ng/ml68996 testsRUO
AbbexaANXA2abx251337Human Annexin A2 (ANXA2) ELISA KitHumanSerum, plasma, tissue homogenates, cell lysates and other biological fluids.Sandwich0.625 ng/ml - 40 ng/ml0.38 ng/ml578.596 testsP07355RUO
AbbexaANXA2abx195131Human Annexin A2 (ANXA2) CLIA KitHumanSerum, plasma and other biological fluids.Sandwich0.156 ng/ml - 10 ng/ml0.1 ng/ml643.596 testsRUO
AbbexaANXA2abx190397Human Annexin A2 (ANXA2) CLIA KitHumanSerum, plasma, tissue homogenates other biological fluids.Sandwich54.9 pg/ml - 40000 pg/ml< 21.7 pg/ml84596 testsRUO
AbbexaANXA2P2abx503302Human Putative annexin A2-like protein (ANXA2P2) ELISA KitHumanSerum, plasma, tissue homogenates, cell lysates and other biological fluids.0.156 ng/ml - 10 ng/ml71596 testsA6NMY6RUO
AbbexaANXA2Rabx503301Human Annexin-2 receptor (ANXA2R) ELISA KitHumanSerum, plasma, tissue homogenates, cell culture supernatants and other biological fluids.0.156 ng/ml - 10 ng/ml71596 testsQ3ZCQ2RUO
FineTestANXA2EM0838Mouse ANXA2(Annexin A2) ELISA KitmouseSerum,Plasma,Tissue homogenates,Other biological fluidsSandwich ELISA, Double Antibody1.563-100ng/ml96TP07356RUO
AbbexaANXA2abx493279Mouse Annexin A2 (ANXA2) CLIA KitMouseSerum, plasma, tissue homogenates and other biological fluids.Sandwich0.156 ng/ml - 10 ng/ml< 0.066 ng/ml84596 testsRUO
AbbexaANXA2abx195132Mouse Annexin A2 (ANXA2) CLIA KitMouseSerum, plasma and other biological fluids.Sandwich0.31 ng/ml - 20 ng/ml0.19 ng/ml643.596 testsRUO
AbbexaANXA2abx255184Mouse Annexin A2 (ANXA2) ELISA KitMouseSerum, plasma, tissue homogenates, cell lysates and other biological fluids.Sandwich1.56 ng/ml - 100 ng/ml0.94 ng/ml578.596 testsP07356RUO
AbbexaANXA2abx153646Mouse Annexin A2 (ANXA2) ELISA KitMouseSerum, plasma and other biological fluids.Sandwich0.156 ng/ml - 10 ng/ml< 0.07 ng/ml70296 testsRUO
AbbexaANXA2abx361278Pig Annexin A2 (ANXA2) ELISA KitPigSerum, plasma and other biological fluids.Sandwich0.625 ng/ml - 40 ng/ml0.38 ng/ml71596 testsRUO
AbbexaANXA2abx493280Rat Annexin A2 (ANXA2) CLIA KitRatSerum, plasma and other biological fluids.Sandwich125 pg/ml - 8000 pg/ml< 43 pg/ml84596 testsRUO
AbbexaANXA2abx155205Rat Annexin A2 (ANXA2) ELISA KitRatSerum, plasma and other biological fluids.Sandwich125 pg/ml - 8000 pg/ml< 43 pg/ml643.596 testsRUO

Primary Antibodies

providerCodereferencenamereactivityclonalityhostimmunogen targetisotypeconjugationtested applicationspricesize 1uniprot idstatus
FineTestANXA2FNab00432anti- Annexin A2 antibodyhumanmonoclonalMouseannexin A2IgG2aUnconjugatedELISA, WB, IHC, IF100µgP07355RUO
FineTestANXA2FNab10399anti- Annexin A2 antibodyhumanpolyclonalRabbitannexin A2IgGUnconjugatedELISA, IHC, WB100µgP07355RUO
AbbexaANXA2abx303059Annexin A2 (ANXA2) Antibody (HRP)HumanPolyclonalRabbitAnnexin A2 (ANXA2)HRPELISA162.520 µgP07355RUO
AbbexaANXA2abx033387Annexin A2 (ANXA2) AntibodyHumanPolyclonalRabbitAnnexin A2 (ANXA2)UnconjugatedELISA, WB, IHC, IF/ICC281.2580 µlP07355RUO
AbbexaANXA2abx100709Annexin A2 (ANXA2) AntibodyHumanPolyclonalRabbitAnnexin A2 (ANXA2)UnconjugatedWB, IHC, IF/ICC262.5100 µlP07355RUO
AbbexaANXA2abx109537Annexin A2 (ANXA2) AntibodyHumanPolyclonalRabbitAnnexin A2 (ANXA2)UnconjugatedELISA, WB162.520 µgP07355RUO
AbbexaANXA2abx210142Annexin A2 (ANXA2) AntibodyHumanMonoclonalMouseAnnexin A2 (ANXA2)UnconjugatedELISA, WB, IHC281.2550 µgP07355RUO
AbbexaANXA2abx230432Annexin A2 (ANXA2) AntibodyHumanMonoclonalMouseAnnexin A2 (ANXA2)UnconjugatedELISA, WB, IHC, IF/ICC350100 µgP07355RUO
AbbexaANXA2abx402590Annexin A2 (ANXA2) AntibodyHumanMonoclonalRabbitAnnexin A2 (ANXA2)UnconjugatedELISA, WB, IHC287.550 µlP07355RUO
AbbexaANXA2abx105143Annexin A2 (ANXA2) Antibody (Biotin)HumanPolyclonalRabbitAnnexin A2 (ANXA2)BiotinELISA162.520 µgP07355RUO
AbbexaANXA2abx106560Annexin A2 (ANXA2) Antibody (FITC)HumanPolyclonalRabbitAnnexin A2 (ANXA2)FITC162.520 µgP07355RUO
AbbexaANXA2abx107977Annexin A2 (ANXA2) Antibody (HRP)HumanPolyclonalRabbitAnnexin A2 (ANXA2)HRPELISA162.520 µgP07355RUO
AbbexaANXA2abx272214Annexin A2 (ANXA2) Antibody (Biotin)HumanPolyclonalRabbitAnnexin A2 (ANXA2)BiotinWB, IHC, IF/ICC350200 µlRUO
AbbexaANXA2abx303061Annexin A2 (ANXA2) Antibody (Biotin)HumanPolyclonalRabbitAnnexin A2 (ANXA2)BiotinELISA162.520 µgP07355RUO
AbbexaANXA2abx038150Annexin-2 (ANXA2) AntibodyHumanPolyclonalRabbitAnnexin-2 (ANXA2)UnconjugatedELISA, WB, IHC337.5100 µgRUO
AbbexaANXA2abx171249Annexin A2 (ANXA2) AntibodyHumanMonoclonalMouseAnnexin A2 (ANXA2)UnconjugatedWB, IHC, IF/ICC275100 µlRUO
AbbexaANXA2abx303060Annexin A2 (ANXA2) Antibody (FITC)HumanPolyclonalRabbitAnnexin A2 (ANXA2)FITC162.520 µgP07355RUO
AbbexaANXA2abx033386Annexin A2 (ANXA2) AntibodyHumanPolyclonalRabbitAnnexin A2 (ANXA2)UnconjugatedELISA, WB, IHC281.2580 µlP07355RUO
AbbexaANXA2abx431134Annexin A2 (ANXA2) AntibodyHumanPolyclonalGoatAnnexin A2 (ANXA2)UnconjugatedP-ELISA, WB387.5200 µlRUO
AbbexaANXA2abx318287Annexin A2 (ANXA2) AntibodyHumanPolyclonalRabbitAnnexin A2 (ANXA2)UnconjugatedELISA, WB, IHC, IF/ICC, IP162.520 µgP07355RUO
AbbexaANXA2abx230431Annexin A2 (ANXA2) AntibodyHumanMonoclonalMouseAnnexin A2 (ANXA2)UnconjugatedELISA, WB, IHC, IF/ICC, FCM, IP350100 µgP07355RUO
AbbexaANXA2abx333359Annexin A2 Phospho-Ser26 (ANXA2 pS26) AntibodyHumanPolyclonalRabbitAnnexin A2 Phospho-Ser26 (ANXA2 pS26)UnconjugatedELISA, WB412.5100 µlP07355RUO
AbbexaANXA2abx001323Annexin A2 (ANXA2) AntibodyHumanPolyclonalRabbitAnnexin A2 (ANXA2)UnconjugatedWB, IHC, IF/ICC17520 µlP07355RUO
AbbexaANXA2abx327036Annexin A2 Phospho-Ser26 (ANXA2 pS26) AntibodyHumanPolyclonalRabbitAnnexin A2 Phospho-Ser26 (ANXA2 pS26)UnconjugatedELISA, WB187.550 µgP07355RUO
AbbexaANXA2abx012741Annexin A2 Phospho-Ser26 (ANXA2 pS26) AntibodyHumanPolyclonalRabbitAnnexin A2 Phospho-Ser26 (ANXA2 pS26)UnconjugatedELISA, WB43.7510 µgP07355RUO
AbbexaANXA2abx213637Annexin A2 (ANXA2) AntibodyHumanPolyclonalRabbitAnnexin A2 (ANXA2)UnconjugatedELISA, WB, IHC25050 µlP07355RUO
AbbexaANXA2abx110995Annexin A2 (ANXA2) AntibodyHumanPolyclonalRabbitAnnexin A2 (ANXA2)UnconjugatedELISA, WB, IHC612.5100 µlP07355RUO
AbbexaANXA2abx214777Annexin A2 (ANXA2) AntibodyHumanPolyclonalRabbitAnnexin A2 (ANXA2)UnconjugatedELISA, WB, IHC25050 µlP07355RUO
AbbexaANXA2abx230430Annexin A2 (ANXA2) AntibodyHumanPolyclonalRabbitAnnexin A2 (ANXA2)UnconjugatedELISA, WB, IHC, IF/ICC350100 µgP07355RUO
AbbexaANXA2abx048475Annexin A2 (ANXA2) AntibodyHumanPolyclonalRabbitAnnexin A2 (ANXA2)UnconjugatedELISA, WB, IHC337.5100 µgRUO
AbbexaANXA2abx327508Annexin A2 (ANXA2) AntibodyHumanPolyclonalRabbitAnnexin A2 (ANXA2)UnconjugatedELISA, WB187.550 µgP07355RUO
AbbexaANXA2abx146597Annexin A2 (ANXA2) AntibodyHumanPolyclonalRabbitAnnexin A2 (ANXA2)UnconjugatedELISA, WB, IHC350100 µgP07355RUO
AbbexaANXA2abx328372Annexin A2 (ANXA2) AntibodyHumanPolyclonalRabbitAnnexin A2 (ANXA2)UnconjugatedELISA, WB, IHC187.550 µgP07355RUO
AbbexaANXA2Rabx339257Annexin A2 Receptor (ANXA2R) AntibodyHumanPolyclonalRabbitAnnexin A2 Receptor (ANXA2R)UnconjugatedELISA, IHC25050 µlQ3ZCQ2RUO
AbbexaANXA2abx129685Annexin A2 (ANXA2) AntibodyMousePolyclonalRabbitAnnexin A2 (ANXA2)UnconjugatedWB, IHC, IF/ICC262.5100 µlP07356RUO
AbbexaANXA2abx175405Annexin A2 (ANXA2) AntibodyRatPolyclonalRabbitAnnexin A2 (ANXA2)UnconjugatedWB, IHC, IF/ICC275100 µlRUO
AbbexaANXA2abx171250Annexin A2 (ANXA2) AntibodyRatMonoclonalMouseAnnexin A2 (ANXA2)UnconjugatedWB, IHC, IF/ICC812.51 mlRUO

Proteins and Peptides

providerCodereferencenameoriginexpressionhostconjugationtested applicationspricesize 1uniprot idstatus
AbbexaANXA2abx652529Mouse Annexin A2 (ANXA2) ProteinMouseRecombinantE. coliUnconjugatedWB, SDS-PAGE20010 µgRUO
AbbexaANXA2abx652182Rat Annexin A2 (ANXA2) ProteinRatRecombinantE. coliUnconjugatedWB, SDS-PAGE20010 µgQ07936RUO
AbbexaANXA2abx260570Human Annexin A2 (ANXA2) ProteinHumanRecombinantE. coliUnconjugatedSDS-PAGE2255 µgP07355RUO
AbbexaANXA2abx065365Human Annexin A2 (ANXA2) ProteinHumanRecombinantE. coliUnconjugatedWB, SDS-PAGE212.510 µgP07355RUO
AbbexaANXA2abx670225Human Annexin II (ANXA2) ProteinHumanE. coliUnconjugatedELISA, WB512.525 µgP07355RUO
AbbexaANXA2abx168339Mouse Annexin A2 (ANXA2) ProteinMouseRecombinantE. coliUnconjugatedWB, SDS-PAGE212.510 µgRUO
AbbexaANXA2abx263373Human Annexin A2 (ANXA2) ProteinHumanNativeHumanUnconjugatedSDS-PAGE2251 µgP07355RUO

Te recomendamos que si no encuentras lo que buscas, utilices el buscador, refinando la búsqueda según tu criterio y usando Alias, o bien contacta con nosotros.