WASF - WASP family member | Elisa - Clia - Antibody - Protein
Family main features
Background
The WASP family of proteins, including WASF (Wiskott-Aldrich Syndrome protein Family), plays a crucial role in actin cytoskeleton remodeling. These proteins are involved in various cellular processes such as cell motility, adhesion, and signaling. WASF proteins are implicated in the regulation of actin polymerization, essential for cellular functions like endocytosis and vesicular trafficking. The dysregulation or mutation of WASP family proteins is linked to several human diseases, including immunodeficiencies, cancer, and neurological disorders.
Protein Structure
WASF proteins typically consist of several functional domains:
- WASP Homology 1 (WH1) Domain: Involved in protein-protein interactions.
- Basic Domain: Interacts with phospholipids and mediates membrane binding.
- GTPase-Binding Domain (GBD): Binds to Rho family GTPases, which regulate the activity of WASF proteins.
- Proline-Rich Domain: Contains multiple proline residues and interacts with SH3 domain-containing proteins.
- Verprolin Homology (V) Domain: Binds to actin monomers.
- Central (C) Domain and Acidic (A) Domain: Involved in actin nucleation and polymerization.
Classification and Subtypes
The WASP family includes several members:
- WASP (Wiskott-Aldrich Syndrome Protein)
- N-WASP (Neural WASP)
- WAVE (WASP-family verprolin-homologous protein)
- WAVE1 (WASF1)
- WAVE2 (WASF2)
- WAVE3 (WASF3)
Function and Biological Significance
- Actin Cytoskeleton Remodeling: WASF proteins are crucial in the dynamic regulation of the actin cytoskeleton, facilitating cellular processes like migration, adhesion, and morphogenesis.
- Signal Transduction: These proteins link extracellular signals to the actin cytoskeleton, translating signals from cell surface receptors into cytoskeletal rearrangements.
- Cellular Functions: WASF proteins are involved in processes like endocytosis, phagocytosis, and the formation of cellular protrusions (e.g., lamellipodia and filopodia).
Clinical Issues
- Wiskott-Aldrich Syndrome: Mutations in the WAS gene cause Wiskott-Aldrich Syndrome, characterized by immunodeficiency, eczema, and thrombocytopenia.
- Cancer: Aberrant expression or mutations in WASF family proteins can contribute to cancer progression and metastasis by affecting cell motility and invasion.
- Neurological Disorders: Dysregulation of WASF proteins is implicated in several neurological disorders, impacting neuronal development and function.
Summary
The WASF family of proteins is integral to the regulation of the actin cytoskeleton, influencing a wide range of cellular processes. These proteins contain multiple domains that facilitate interactions with actin and other proteins, enabling them to remodel the cytoskeleton in response to extracellular signals. WASF proteins are critical for cell motility, adhesion, and signaling, with mutations or dysregulation associated with various diseases, including immunodeficiencies, cancer, and neurological disorders. Understanding the structure and function of WASF proteins is essential for elucidating their roles in health and disease.
WASF1 Recommended name:
WASP family member 1 (WASF1)
Aliases for WASF1
WAVE,SCAR1,WAVE1,NEDALVS,Actin-binding protein WASF1,Verprolin homology domain-containing protein 1,Wiskott-Aldrich syndrome protein family member 1
WASF2 Recommended name:
WASP family member 2 (WASF2)
Aliases for WASF2
IMD2,SCAR2,WASF4,WAVE2,Actin-binding protein WASF2,Verprolin homology domain-containing protein 2,Wiskott-Aldrich syndrome protein family member 2
WASF3 Recommended name:
WASP family member 3 (WASF3)
Aliases for WASF3
SCAR3,WAVE3,Brush-1,Actin-binding protein WASF3,Verprolin homology domain-containing protein 3,Wiskott-Aldrich syndrome protein family member 3
WASF4P Recommended name:
WASP family member 4, pseudogene (WASF4P)
Aliases for WASF4P
WASF4
En la tabla siguiente se muestra una comparativa de todos los reactivos disponibles en nuestro catálogo (Primary Antibodies, ELISA Kits, Proteins and Peptides, CLIA Kits) relacionados con WASF - WASP family member
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Esta página contiene 40 reactivos de las marcas (Abbexa, FineTest) que se corresponden con tu busqueda
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immunoassays
| provider | Code | reference | name | reactivity | sample type | assay type | test range | sensitivity | price | size 1 | uniprot id | status |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Abbexa | WASF1 | abx553296 | Human Wiskott-Aldrich syndrome protein family member 1 (WASF1) ELISA Kit | Human | Tissue homogenates,Cell lysates,Other biological fluids | 0.156 ng/ml - 10 ng/ml | 687.5 | 96 tests | Q92558 | RUO | ||
| Abbexa | WASF2 | abx494725 | Human Wiskott Aldrich Syndrome Protein Family Member 2 (WASF2) CLIA Kit | Human | Tissue homogenates and other biological fluids. | Sandwich | 0.312 ng/ml - 20 ng/ml | < 0.106 ng/ml | 812.5 | 96 tests | RUO | |
| Abbexa | WASF2 | abx153496 | Human Wiskott Aldrich Syndrome Protein Family Member 2 (WASF2) ELISA Kit | Human | Tissue homogenates,Other biological fluids | Sandwich | 0.312 ng/ml - 20 ng/ml | < 0.11 ng/ml | 687.5 | 96 tests | RUO | |
| Abbexa | WASF3 | abx553302 | Human Wiskott-Aldrich syndrome protein family member 3 (WASF3) ELISA Kit | Human | Tissue homogenates,Cell lysates,Other biological fluids | 0.156 ng/ml - 10 ng/ml | 687.5 | 96 tests | Q9UPY6 | RUO | ||
| Abbexa | WASF1 | abx553297 | Mouse Wiskott-Aldrich syndrome protein family member 1 (WASF1) ELISA Kit | Mouse | Tissue homogenates,Cell lysates,Other biological fluids | 0.156 ng/ml - 10 ng/ml | 687.5 | 96 tests | Q8R5H6 | RUO | ||
| Abbexa | WASF2 | abx154861 | Mouse Wiskott Aldrich Syndrome Protein Family Member 2 (WASF2) ELISA Kit | Mouse | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 0.156 ng/ml - 10 ng/ml | < 0.06 ng/ml | 687.5 | 96 tests | RUO | |
| Abbexa | WASF2 | abx494726 | Mouse Wiskott Aldrich Syndrome Protein Family Member 2 (WASF2) CLIA Kit | Mouse | Tissue homogenates, cell lysates and other biological fluids. | Sandwich | 0.156 ng/ml - 10 ng/ml | < 0.053 ng/ml | 812.5 | 96 tests | RUO | |
| Abbexa | WASF3 | abx553303 | Mouse Wiskott-Aldrich syndrome protein family member 3 (WASF3) ELISA Kit | Mouse | Tissue homogenates,Cell lysates,Other biological fluids | 0.156 ng/ml - 10 ng/ml | 687.5 | 96 tests | Q8VHI6 | RUO | ||
| Abbexa | WASF1 | abx553298 | Rat WAS Protein Family Member 1 (WASF1) ELISA Kit | Rat | Tissue homogenates,Cell lysates,Other biological fluids | 0.156 ng/ml - 10 ng/ml | 687.5 | 96 tests | Q5BJU7 | RUO |
Primary Antibodies
| provider | Code | reference | name | reactivity | clonality | host | immunogen target | isotype | conjugation | tested applications | price | size 1 | uniprot id | status |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Abbexa | WASF1 | abx430468 | WAS Protein Family Member 1 (WASF1) Antibody | Polyclonal | Goat | WAS Protein Family Member 1 (WASF1) | Unconjugated | P-ELISA | 250 | 200 µl | RUO | |||
| FineTest | WASF4P | FNab09469 | anti- WASF4-Specific antibody | human | polyclonal | Rabbit | WAS protein family, member 4 | IgG | Unconjugated | ELISA, WB, IF | 100µg | Q8IV90 | RUO | |
| Abbexa | WASF1 | abx317605 | WASF1 Antibody (FITC) | Human | Polyclonal | Rabbit | WASF1 | FITC | 162.5 | 20 µg | Q92558 | RUO | ||
| Abbexa | WASF1 | abx317606 | WASF1 Antibody (Biotin) | Human | Polyclonal | Rabbit | WASF1 | Biotin | ELISA | 162.5 | 20 µg | Q92558 | RUO | |
| Abbexa | WASF1 | abx317604 | WASF1 Antibody (HRP) | Human | Polyclonal | Rabbit | WASF1 | HRP | ELISA | 162.5 | 20 µg | Q92558 | RUO | |
| Abbexa | WASF1 | abx333069 | WAS Protein Family Member 1 Phospho-Tyr125 (WASF1 pY125) Antibody | Human | Polyclonal | Rabbit | WAS Protein Family Member 1 Phospho-Tyr125 (WASF1 pY125) | Unconjugated | ELISA, WB, IHC | 412.5 | 100 µl | Q92558 | RUO | |
| Abbexa | WASF1 | abx329512 | WAS Protein Family Member 1 (WASF1) Antibody | Human | Polyclonal | Rabbit | WAS Protein Family Member 1 (WASF1) | Unconjugated | ELISA, WB, IHC, IF/ICC | 187.5 | 50 µg | Q92558 | RUO | |
| Abbexa | WASF1 | abx329632 | WAS Protein Family Member 1 Phospho-Tyr125 (WASF1 pY125) Antibody | Human | Polyclonal | Rabbit | WAS Protein Family Member 1 Phospho-Tyr125 (WASF1 pY125) | Unconjugated | ELISA, WB, IHC, IF/ICC | 187.5 | 50 µg | Q92558 | RUO | |
| Abbexa | WASF1 | abx318778 | WAS Protein Family Member 1 (WASF1) Antibody | Human | Polyclonal | Rabbit | WAS Protein Family Member 1 (WASF1) | Unconjugated | ELISA, WB, IHC | 162.5 | 20 µg | Q92558 | RUO | |
| Abbexa | WASF2 | abx334244 | Wiskott Aldrich Syndrome Protein Family, Member 2 (WASF2) Antibody | Human | Polyclonal | Rabbit | Wiskott Aldrich Syndrome Protein Family, Member 2 (WASF2) | Unconjugated | ELISA, IHC, IF/ICC | 162.5 | 20 µg | Q9Y6W5 | RUO | |
| Abbexa | WASF2 | abx338318 | Wiskott Aldrich Syndrome Protein Family, Member 2 (WASF2) Antibody (FITC) | Human | Polyclonal | Rabbit | Wiskott Aldrich Syndrome Protein Family, Member 2 (WASF2) | FITC | 162.5 | 20 µg | Q9Y6W5 | RUO | ||
| Abbexa | WASF2 | abx338317 | Wiskott Aldrich Syndrome Protein Family, Member 2 (WASF2) Antibody (HRP) | Human | Polyclonal | Rabbit | Wiskott Aldrich Syndrome Protein Family, Member 2 (WASF2) | HRP | ELISA | 162.5 | 20 µg | Q9Y6W5 | RUO | |
| Abbexa | WASF2 | abx028127 | Wiskott Aldrich Syndrome Protein Family Member 2 (WASF2) Antibody | Human | Polyclonal | Rabbit | Wiskott Aldrich Syndrome Protein Family Member 2 (WASF2) | Unconjugated | ELISA, WB | 250 | 80 µl | Q9Y6W5 | RUO | |
| Abbexa | WASF2 | abx122003 | Wiskott Aldrich Syndrome Protein Family Member 2 (WASF2) Antibody | Human | Polyclonal | Rabbit | Wiskott Aldrich Syndrome Protein Family Member 2 (WASF2) | Unconjugated | ELISA, WB | 337.5 | 100 µg | Q9Y6W5 | RUO | |
| Abbexa | WASF2 | abx338319 | Wiskott Aldrich Syndrome Protein Family, Member 2 (WASF2) Antibody (Biotin) | Human | Polyclonal | Rabbit | Wiskott Aldrich Syndrome Protein Family, Member 2 (WASF2) | Biotin | ELISA | 162.5 | 20 µg | Q9Y6W5 | RUO | |
| Abbexa | WASF2 | abx213581 | Wiskott Aldrich Syndrome Protein Family, Member 2 (WASF2) Antibody | Human | Polyclonal | Rabbit | Wiskott Aldrich Syndrome Protein Family, Member 2 (WASF2) | Unconjugated | ELISA, WB | 250 | 50 µl | Q9Y6W5 | RUO | |
| Abbexa | WASF2 | abx211873 | Wiskott Aldrich Syndrome Protein Family, Member 2 (WASF2) Antibody | Human | Polyclonal | Rabbit | Wiskott Aldrich Syndrome Protein Family, Member 2 (WASF2) | Unconjugated | ELISA, WB, IHC | 250 | 50 µl | Q9Y6W5 | RUO | |
| Abbexa | WASF2 | abx329141 | Wiskott Aldrich Syndrome Protein Family, Member 2 (WASF2) Antibody | Human | Polyclonal | Rabbit | Wiskott Aldrich Syndrome Protein Family, Member 2 (WASF2) | Unconjugated | ELISA, WB, IHC | 187.5 | 50 µg | Q9Y6W5 | RUO | |
| Abbexa | WASF2 | abx015005 | Wiskott Aldrich Syndrome Protein Family Member 2 (WASF2) Antibody | Human | Polyclonal | Rabbit | Wiskott Aldrich Syndrome Protein Family Member 2 (WASF2) | Unconjugated | WB, IHC | 43.75 | 10 µg | Q9Y6W5 | RUO | |
| Abbexa | WASF3 | abx122243 | WAS Protein Family Member 3 (WASF3) Antibody | Human | Polyclonal | Rabbit | WAS Protein Family Member 3 (WASF3) | Unconjugated | ELISA, WB | 337.5 | 100 µg | RUO | ||
| Abbexa | WASF3 | abx338507 | WAS Protein Family Member 3 (WASF3) Antibody | Human | Polyclonal | Rabbit | WAS Protein Family Member 3 (WASF3) | Unconjugated | ELISA, WB, IHC, IF/ICC | 162.5 | 20 µg | Q9UPY6 | RUO | |
| Abbexa | WASF3 | abx338322 | WAS Protein Family Member 3 (WASF3) Antibody (Biotin) | Human | Polyclonal | Rabbit | WAS Protein Family Member 3 (WASF3) | Biotin | ELISA | 162.5 | 20 µg | Q9UPY6 | RUO | |
| Abbexa | WASF3 | abx338321 | WAS Protein Family Member 3 (WASF3) Antibody (FITC) | Human | Polyclonal | Rabbit | WAS Protein Family Member 3 (WASF3) | FITC | 162.5 | 20 µg | Q9UPY6 | RUO | ||
| Abbexa | WASF3 | abx338320 | WAS Protein Family Member 3 (WASF3) Antibody (HRP) | Human | Polyclonal | Rabbit | WAS Protein Family Member 3 (WASF3) | HRP | ELISA | 162.5 | 20 µg | Q9UPY6 | RUO | |
| Abbexa | WASF3 | abx212571 | WAS Protein Family Member 3 (WASF3) Antibody | Human | Polyclonal | Rabbit | WAS Protein Family Member 3 (WASF3) | Unconjugated | ELISA, IHC | 250 | 50 µl | Q9UPY6 | RUO | |
| Abbexa | WASF3 | abx325793 | WAS Protein Family Member 3 (WASF3) Antibody | Human | Polyclonal | Rabbit | WAS Protein Family Member 3 (WASF3) | Unconjugated | ELISA, WB, IHC | 187.5 | 50 µg | Q9UPY6 | RUO | |
| Abbexa | WASF3 | abx015006 | WAS Protein Family Member 3 (WASF3) Antibody | Human | Polyclonal | Rabbit | WAS Protein Family Member 3 (WASF3) | Unconjugated | WB, IHC | 43.75 | 10 µg | Q9UPY6 | RUO | |
| Abbexa | WASF4P | abx239469 | WASF4-Specific Antibody | Human | Polyclonal | Rabbit | WASF4-Specific | Unconjugated | ELISA, WB, IF/ICC | 350 | 100 µg | Q8IV90 | RUO |
Proteins and Peptides
| provider | Code | reference | name | origin | expression | host | conjugation | tested applications | price | size 1 | uniprot id | status |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Abbexa | WASF2 | abx655523 | Mouse Wiskott Aldrich Syndrome Protein Family, Member 2 (WASF2) Protein | Mouse | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 1800 | 1 mg | RUO | |
| Abbexa | WASF2 | abx655522 | Human Wiskott Aldrich Syndrome Protein Family, Member 2 (WASF2) Protein | Human | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 1800 | 1 mg | RUO | |
| FineTest | WASF4P | P5912 | Recombinant Human WASH complex subunit 4 | Human | Recombinant | E.Coli | Western Blot，ELISA | 50μg | Q2M389 | RUO |
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