Wiskott Aldrich Syndrome Protein Family Member 2 (WASF2) Antibody
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Description
Rabbit polyclonal antibody against WASF2 protein. Immunogen region is Internal.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Wiskott Aldrich Syndrome Protein Family Member 2 (WASF2) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1/500 - 1/3000, IHC: 1/50 - 1/100, ELISA: 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified from rabbit antiserum by affinity chromatography using epitope-specific immunogen. |
| Size 1 | 10 µg |
| Size 2 | 100 µg |
| Size 3 | 200 µg |
| Size 4 | 300 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC |
| Buffer | PBS (without Mg<sup>2+</sup> and Ca<sup>2+</sup>), pH 7.4, 150 mM NaCl, 0.02% sodium azide, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9Y6W5 |
| Alias | IMD2,SCAR2,WASF4,WAVE2,Actin-binding protein WASF2,Verprolin homology domain-containing protein 2,Wiskott-Aldrich syndrome protein family member 2 |
| Background | Antibody anti-WASF2 |
| Status | RUO |
| Note | Concentration: 1 mg/ml - |
Descripción
WASP family member 2 (WASF2), also known as WAVE2, is another member of the WASP family of proteins that regulates actin dynamics and cellular movement WASF2 is part of a multi-protein complex that activates the Arp2/3 complex to promote actin filament branching, a critical process for cellular motility, migration, and invasion WASF2 is highly expressed in cells that require dynamic cytoskeletal changes, such as in immune cells, neurons, and cancer cells In immune cells, WASF2 is involved in processes like T-cell activation and phagocytosis, while in cancer cells, it regulates cell invasion and metastasis through changes in actin remodeling Dysregulation of WASF2 is associated with diseases such as immune disorders, cancer metastasis, and neurodevelopmental disorders, where aberrant actin dynamics lead to impaired immune function or abnormal cell movement
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