Wiskott Aldrich Syndrome Protein Family Member 2 (WASF2) Antibody

Background

WASP family member 2 (WASF2), also known as WAVE2, is another member of the WASP family of proteins that regulates actin dynamics and cellular movement WASF2 is part of a multi-protein complex that activates the Arp2/3 complex to promote actin filament branching, a critical process for cellular motility, migration, and invasion WASF2 is highly expressed in cells that require dynamic cytoskeletal changes, such as in immune cells, neurons, and cancer cells In immune cells, WASF2 is involved in processes like T-cell activation and phagocytosis, while in cancer cells, it regulates cell invasion and metastasis through changes in actin remodeling Dysregulation of WASF2 is associated with diseases such as immune disorders, cancer metastasis, and neurodevelopmental disorders, where aberrant actin dynamics lead to impaired immune function or abnormal cell movement