SIRT3 - Sirtuin 3 | Elisa - Clia - Antibody - Protein

Family main features

Background:

SIRT3, also known as NAD-dependent protein deacetylase sirtuin-3, is a member of the sirtuin family of proteins, which are involved in various cellular processes including metabolism, stress response, and aging. SIRT3 is primarily localized in the mitochondria, the cellular organelles responsible for energy production and other critical metabolic functions. One of the key functions of SIRT3 is its role in regulating mitochondrial metabolism. SIRT3 targets several proteins within the mitochondria, including enzymes involved in oxidative phosphorylation, the citric acid cycle (also known as the Krebs cycle), fatty acid metabolism, and antioxidant defense mechanisms. By deacetylating these target proteins, SIRT3 enhances their activity, leading to increased energy production, improved mitochondrial function, and protection against oxidative stress.SIRT3 has been shown to play a critical role in cellular responses to stress, including oxidative stress and nutrient deprivation. It promotes cell survival under conditions of metabolic stress by regulating mitochondrial metabolism and maintaining cellular energy balance. Additionally, SIRT3 has been implicated in the regulation of apoptosis and the cellular response to DNA damage.


Protein Structure:

  • Composition: SIRT3 is composed of 399 amino acids.
  • Domains:
  • N-terminal Mitochondrial Targeting Sequence: Directs the protein to the mitochondria.
  • Catalytic Core: Contains the NAD+-binding site and the deacetylase domain essential for its enzymatic activity.
  • C-terminal Domain: Important for protein stability and function.
  • Post-translational Modifications: SIRT3 activity is regulated by various post-translational modifications, including phosphorylation and acetylation.


Classification and Subtypes:

  • Family: SIRT3 belongs to the sirtuin family, which includes seven members (SIRT1-7) in mammals.
  • Subtypes: There are no specific subtypes of SIRT3, but its functions overlap with other mitochondrial sirtuins, particularly SIRT4 and SIRT5.


Function and Biological Significance:

  • Mitochondrial Function: SIRT3 regulates mitochondrial biogenesis, dynamics, and respiration by deacetylating and activating key enzymes involved in the electron transport chain and fatty acid oxidation.
  • Energy Metabolism: SIRT3 deacetylates and activates enzymes like acetyl-CoA synthetase 2 (AceCS2) and long-chain acyl-CoA dehydrogenase (LCAD), enhancing fatty acid oxidation and ketone body production.
  • Antioxidant Defense: SIRT3 promotes the deacetylation and activation of manganese superoxide dismutase (MnSOD), reducing reactive oxygen species (ROS) and protecting cells from oxidative stress.
  • Apoptosis Regulation: SIRT3 modulates the intrinsic pathway of apoptosis by deacetylating and regulating proteins such as cyclophilin D, influencing the opening of the mitochondrial permeability transition pore.
  • Metabolic Adaptation: SIRT3 is involved in adapting to metabolic stress, such as fasting and calorie restriction, by reprogramming cellular energy metabolism.


Interactions:

  • Metabolic Enzymes: SIRT3 interacts with and deacetylates various metabolic enzymes, including AceCS2, LCAD, and isocitrate dehydrogenase 2 (IDH2), enhancing their activities and promoting efficient energy production.
  • Antioxidant Proteins: SIRT3 deacetylates and activates MnSOD, a critical enzyme in the mitochondrial antioxidant defense system.
  • Apoptotic Regulators: SIRT3 modulates apoptosis by deacetylating proteins involved in the mitochondrial apoptosis pathway, such as cyclophilin D.


Clinical Issues:

  • Metabolic Disorders: Dysregulation of SIRT3 is linked to metabolic disorders, including obesity, type 2 diabetes, and non-alcoholic fatty liver disease (NAFLD). Enhancing SIRT3 activity could be beneficial in these conditions.
  • Aging and Longevity: SIRT3 is implicated in the aging process and age-related diseases. It plays a role in promoting healthy aging by enhancing mitochondrial function and reducing oxidative stress.
  • Cardiovascular Diseases: SIRT3 is protective against cardiovascular diseases by maintaining mitochondrial integrity and function, reducing oxidative stress, and preventing apoptosis in cardiac cells.
  • Cancer: The role of SIRT3 in cancer is complex and context-dependent. It can act as a tumor suppressor by enhancing mitochondrial function and reducing ROS levels. However, in some cancers, SIRT3 may support tumor growth by adapting metabolism to support rapid cell proliferation.


Summary:

Sirtuin 3 (SIRT3) is a mitochondrial NAD+-dependent deacetylase that plays a crucial role in regulating mitochondrial function, energy metabolism, and cellular stress responses. By deacetylating key metabolic enzymes and antioxidant proteins, SIRT3 enhances mitochondrial efficiency, promotes fatty acid oxidation, and reduces oxidative stress. SIRT3 is involved in various physiological processes, including aging, metabolic adaptation, and apoptosis regulation. Dysregulation of SIRT3 is associated with metabolic disorders, aging, cardiovascular diseases, and cancer, making it a potential therapeutic target for these conditions.


SIRT3 Recommended name:

NAD-dependent protein deacetylase sirtuin-3 (SIRT3)

Aliases for SIRT3

SIR2L3,NAD-dependent protein deacetylase sirtuin-3 mitochondrial,SIR2-like protein 3,SIR2L3,hSIRT3

En la tabla siguiente se muestra una comparativa de todos los reactivos disponibles en nuestro catálogo (Proteins and Peptides, Primary Antibodies, ELISA Kits, CLIA Kits) relacionados con SIRT3 - Sirtuin 3

Se muestran ordenados por categorías para poder comparar cómodamente sus características principales. Esta tabla, que contiene un enlace con la ficha de cada producto, es exportable a Excel.

Esta página contiene 48 reactivos de las marcas (Abbexa, FineTest) que se corresponden con tu busqueda

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immunoassays

providerCodereferencenamereactivitysample typeassay typetest rangesensitivitypricesize 1uniprot idstatus
FineTestSIRT3EH4451Human SIRT3(NAD-dependent ADP-ribosyltransferase sirtuin-4) ELISA KithumanSerum,Plasma,Tissue homogenates,Other biological fluidsSandwich ELISA, Double Antibody0.156-10ng/ml96TO75094RUO
AbbexaSIRT3abx153094Human Sirtuin 3 (SIRT3) ELISA KitHumanTissue homogenates, cell lysates, cell culture supernatants and other biological fluids.Sandwich0.156 ng/ml - 10 ng/ml< 0.061 ng/ml643.596 testsQ9NTG7RUO
AbbexaSIRT3abx494778Human Sirtuin 3 (SIRT3) CLIA KitHumanTissue homogenates, cell lysates and other biological fluids.Sandwich0.312 ng/ml - 20 ng/ml< 0.112 ng/ml84596 testsRUO
FineTestSIRT3EM0731Mouse Sirt3(NAD-dependent deacetylase sirtuin-3) ELISA KitmouseSerum,Plasma,Tissue homogenates,Other biological fluidsSandwich ELISA, Double Antibody0.313-20ng/ml96TQ8R104RUO
AbbexaSIRT3abx494779Mouse Sirtuin 3 (SIRT3) CLIA KitMouseTissue homogenates, cell lysates and other biological fluids.Sandwich0.156 ng/ml - 10 ng/ml< 0.054 ng/ml84596 testsRUO
AbbexaSIRT3abx154678Mouse Sirtuin 3 (SIRT3) ELISA KitMouseTissue homogenates, cell lysates and other biological fluids.Sandwich0.156 ng/ml - 10 ng/ml< 0.06 ng/ml643.596 testsRUO
AbbexaSIRT3abx156091Rat Sirtuin 3 (SIRT3) ELISA KitRatTissue homogenates, cell lysates and other biological fluids.Sandwich0.156 ng/ml - 10 ng/ml< 0.06 ng/ml71596 testsRUO
AbbexaSIRT3abx494780Rat Sirtuin 3 (SIRT3) CLIA KitRatTissue homogenates, cell lysates and other biological fluids.Sandwich0.156 ng/ml - 10 ng/ml< 0.053 ng/ml84596 testsRUO

Primary Antibodies

providerCodereferencenamereactivityclonalityhostimmunogen targetisotypeconjugationtested applicationspricesize 1uniprot idstatus
FineTestSIRT3FNab07881anti- SIRT3 antibodyhumanpolyclonalRabbitsirtuin (silent mating type information regulation 2 homolog) 3 IgGUnconjugatedELISA, WB, IHC, IF100µgQ9NTG7RUO
AbbexaSIRT3abx321567Sirtuin 3 (SIRT3) AntibodyHumanPolyclonalRabbitSirtuin 3 (SIRT3)IgGUnconjugatedELISA, WB, IHC16920 µlQ9NTG7RUO
AbbexaSIRT3abx272368Sirtuin 3 (SIRT3) Antibody (Biotin)HumanPolyclonalRabbitSirtuin 3 (SIRT3)IgGBiotinWB, IHC, IF/ICC377200 µlRUO
AbbexaSIRT3abx316590Sirtuin 3 (SIRT3) Antibody (Biotin)HumanPolyclonalRabbitSirtuin 3 (SIRT3)IgGBiotinELISA16920 µgQ9NTG7RUO
AbbexaSIRT3abx273581Sirtuin 3 (SIRT3) Antibody (FITC)HumanPolyclonalRabbitSirtuin 3 (SIRT3)IgGFITCWB, IHC, IF/ICC455200 µlRUO
AbbexaSIRT3abx028151Sirtuin 3 (SIRT3) AntibodyHumanPolyclonalRabbitSirtuin 3 (SIRT3)IgGUnconjugatedELISA, WB292.580 µlQ9NTG7RUO
AbbexaSIRT3abx036063Sirtuin 3 (SIRT3) AntibodyHumanPolyclonalRabbitSirtuin 3 (SIRT3)IgGUnconjugatedELISA, WB, IHC357.5100 µgRUO
AbbexaSIRT3abx100645Sirtuin 3 (SIRT3) AntibodyHumanPolyclonalRabbitSirtuin 3 (SIRT3)UnconjugatedWB, IHC, IF/ICC286100 µlQ9NTG7RUO
AbbexaSIRT3abx100647Sirtuin 3 (SIRT3) AntibodyHumanMonoclonalMouseSirtuin 3 (SIRT3)IgG1 KappaUnconjugatedWB, IHC, IF/ICC286100 µlRUO
AbbexaSIRT3abx433275Sirtuin 3 (SIRT3) AntibodyHumanPolyclonalGoatSirtuin 3 (SIRT3)IgGUnconjugatedP-ELISA, WB416200 µlRUO
AbbexaSIRT3abx324025Sirtuin 3 (SIRT3) AntibodyHumanPolyclonalRabbitSirtuin 3 (SIRT3)IgGUnconjugatedELISA, WB22150 µgQ9NTG7RUO
AbbexaSIRT3abx224230Sirtuin 3 (SIRT3) AntibodyHumanMonoclonalMouseSirtuin 3 (SIRT3)IgG1ELISA383.5100 µlQ9NTG7RUO
AbbexaSIRT3abx224373Sirtuin 3 (SIRT3) AntibodyHumanMonoclonalMouseSirtuin 3 (SIRT3)IgG1UnconjugatedELISA, WB, FCM383.5100 µlQ9NTG7RUO
AbbexaSIRT3abx015065Sirtuin 3 (SIRT3) AntibodyHumanPolyclonalRabbitSirtuin 3 (SIRT3)IgGUnconjugatedELISA, WB5210 µgQ9NTG7RUO
AbbexaSIRT3abx316588Sirtuin 3 (SIRT3) Antibody (HRP)HumanPolyclonalRabbitSirtuin 3 (SIRT3)IgGHRPELISA16920 µgQ9NTG7RUO
AbbexaSIRT3abx457251NAD-Dependent Protein Deacetylase Sirtuin-3, Mitochondrial (SIRT3) AntibodyHumanPolyclonalRabbitNAD-Dependent Protein Deacetylase Sirtuin-3, Mitochondrial (SIRT3)IgGUnconjugatedELISA, WB, IHC26050 µgQ9NTG7RUO
AbbexaSIRT3abx316589Sirtuin 3 (SIRT3) Antibody (FITC)HumanPolyclonalRabbitSirtuin 3 (SIRT3)IgGFITC16920 µgQ9NTG7RUO
AbbexaSIRT3abx321451Sirtuin 3 (SIRT3) AntibodyHumanPolyclonalRabbitSirtuin 3 (SIRT3)IgGUnconjugatedELISA, WB, IHC16920 µlQ9NTG7RUO
AbbexaSIRT3abx211521Sirtuin 3 (SIRT3) AntibodyHumanPolyclonalRabbitSirtuin 3 (SIRT3)IgGUnconjugatedELISA, IHC26050 µlQ9NTG7RUO
AbbexaSIRT3abx318089Sirtuin 3 (SIRT3) AntibodyHumanPolyclonalRabbitSirtuin 3 (SIRT3)IgGUnconjugatedELISA, WB, IF/ICC16920 µgQ9NTG7RUO
AbbexaSIRT3abx213139Sirtuin 3 (SIRT3) AntibodyHumanPolyclonalRabbitSirtuin 3 (SIRT3)IgGUnconjugatedELISA, WB, IHC26050 µlQ9NTG7RUO
AbbexaSIRT3abx032747Sirtuin 3 (SIRT3) AntibodyHumanPolyclonalRabbitSirtuin 3 (SIRT3)IgGUnconjugatedELISA, WB, IHC292.580 µlQ9NTG7RUO
AbbexaSIRT3abx005514Sirtuin 3 (SIRT3) AntibodyHumanPolyclonalRabbitSirtuin 3 (SIRT3)IgGUnconjugatedELISA, WB, IHC, IF/ICC, IP19520 µlQ9NTG7RUO
AbbexaSIRT3abx237881Sirtuin 3 (SIRT3) AntibodyHumanPolyclonalRabbitSirtuin 3 (SIRT3)IgGUnconjugatedELISA, WB, IHC, IF/ICC364100 µgQ9NTG7RUO
AbbexaSIRT3abx004372Sirtuin 3 (SIRT3) AntibodyHumanPolyclonalRabbitSirtuin 3 (SIRT3)IgGUnconjugatedELISA, WB, IHC, IF/ICC20820 µlQ9NTG7RUO
AbbexaSIRT3abx129703Sirtuin 3 (SIRT3) AntibodyMousePolyclonalRabbitSirtuin 3 (SIRT3)UnconjugatedWB, IHC, IF/ICC286100 µlQ8R104RUO
AbbexaSIRT3abx432056Sirtuin 3 (SIRT3) AntibodyMousePolyclonalGoatSirtuin 3 (SIRT3)IgGUnconjugatedP-ELISA, WB, IF/ICC, FCM416200 µlRUO
AbbexaSIRT3abx174558Sirtuin 3 (SIRT3) AntibodyRatMonoclonalMouseSirtuin 3 (SIRT3)UnconjugatedWB, IHC, IF/ICC8841 mlRUO
AbbexaSIRT3abx273295Sirtuin 3 (SIRT3) Antibody (Biotin)RatPolyclonalRabbitSirtuin 3 (SIRT3)IgGBiotinWB, IHC, IF/ICC403200 µlRUO
AbbexaSIRT3abx100648Sirtuin 3 (SIRT3) AntibodyRatPolyclonalRabbitSirtuin 3 (SIRT3)UnconjugatedWB, IHC, IF/ICC299100 µlC6ZII9RUO

Proteins and Peptides

providerCodereferencenameoriginexpressionhostconjugationtested applicationspricesize 1uniprot idstatus
AbbexaSIRT3abx167224Mouse Sirtuin 3 (SIRT3) ProteinMouseRecombinantE. coliUnconjugatedWB, SDS-PAGE22110 µgQ8R104RUO
AbbexaSIRT3abx651440Mouse Sirtuin 3 (SIRT3) ProteinMouseE. coliUnconjugatedWB, SDS-PAGE65050 µgQ8R104RUO
AbbexaSIRT3abx166415Human Sirtuin 3 (SIRT3) ProteinHumanRecombinantE. coliUnconjugatedWB, SDS-PAGE20810 µgRUO
AbbexaSIRT3abx616606Sirtuin 3 (SIRT3) PeptideSyntheticUnconjugatedP-ELISA175.5100 µg
AbbexaSIRT3abx651441Rat Sirtuin 3 (SIRT3) ProteinRatE. coliUnconjugatedWB, SDS-PAGE70250 µgC6ZII9RUO
AbbexaSIRT3abx269781Sirtuin 3 (SIRT3) PeptideSyntheticUnconjugatedP-ELISA175.5100 µg
AbbexaSIRT3abx655827Human Sirtuin 3 (SIRT3) ProteinHumanRecombinantE. coliUnconjugatedWB, SDS-PAGE55950 µgQ9NTG7RUO
AbbexaSIRT3abx069102Rat Sirtuin 3 (SIRT3) ProteinRatRecombinantE. coliUnconjugatedWB, SDS-PAGE23410 µgC6ZII9RUO
FineTestSIRT3P6799Recombinant Human SIRT3HumanRecombinantE.ColiWestern Blot,ELISA50μgQ9NTG7RUO
AbbexaSIRT3abx262846Sirtuin-3 ProteinRecombinantUnconjugatedSDS-PAGE2342 µgQ9NTG7RUO

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