Human SIRT3 (NAD-dependent ADP-ribosyltransferase sirtuin-4) ELISA Kit
Contáctenos para saber el precio
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
935106861
info@markelab.com
name
Human SIRT3 (NAD-dependent ADP-ribosyltransferase sirtuin-4) ELISA Kit
category
ELISA Kits
provider
FineTest
reference
EH4451
tested applications
ELISA
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | ELISA Kits |
| Reactivity | Human |
| Detection Method | Colorimetric |
| Assay Data | 4 hours |
| Assay Type | Sandwich ELISA, Double Antibody |
| Test Range | 0.156-10ng/ml |
| Sensitivity | 0.094ng/ml |
| Size 1 | 96T |
| Tested Applications | ELISA |
| Sample Type | cell or tissue lysate, Other liquid samples |
| Availability | Shipped within 10-14 working days. |
| Storage | 2-8 °C for 12 months |
| UniProt ID | O75094 |
| Alias | SIR2L3,NAD-dependent protein deacetylase sirtuin-3 mitochondrial,SIR2-like protein 3,SIR2L3,hSIRT3 |
| Background | Elisa kits for SIRT3 |
| Status | RUO |
SIRT3 is a NAD+-dependent deacetylase primarily localized in the mitochondria, where it plays a critical role in regulating mitochondrial metabolism, energy production, and oxidative stress response SIRT3 deacetylates and activates key mitochondrial enzymes, including acetyl-CoA synthetase 2 (ACSS2), superoxide dismutase 2 (SOD2), and components of the electron transport chain, enhancing ATP production, fatty acid oxidation, and antioxidant defense SIRT3 is essential for maintaining mitochondrial homeostasis during energy stress, such as fasting or caloric restriction, by stimulating pathways that improve energy efficiency and reduce reactive oxygen species (ROS) levels SIRT3 also promotes cellular survival under oxidative stress by deacetylating SOD2, which neutralizes superoxide radicals Dysregulation of SIRT3 is associated with aging, metabolic disorders, cardiovascular disease, and neurodegeneration, where impaired mitochondrial function leads to cellular damage and energy deficiency SIRT3 has tumor suppressor properties as it inhibits aerobic glycolysis (Warburg effect) in cancer cells by regulating key metabolic enzymes Its activation is being explored as a therapeutic strategy to combat mitochondrial dysfunction, improve metabolic health, and delay aging-related diseases
Related Products
Mouse Sirtuin 3 (SIRT3) ELISA Kit
Mouse Sirtuin 3 (SIRT3) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Mouse Sirtuin 3 concentrations in tissue homogenates, cell lysates and other biological fluids. This assay has high sensitivity and excellent specificity for detection of Sirtuin 3 (SIRT3)
Ver Producto
Human Sirtuin 3 (SIRT3) CLIA Kit
Human Sirtuin 3 (SIRT3) Chemiluminescent Immunoassay (CLIA) Kit is a Sandwich Chemiluminescent Immunoassay (CLIA) Kit for use with Tissue homogenates, cell lysates and other biological fluids.
Ver Producto
Rat Sirtuin 3 (SIRT3) Protein
Sirtuin 3 (SIRT3) Protein (Active) is an active protein from Rat.
Ver Producto