Rat NAD-Dependent Protein Deacetylase Sirtuin-3, Mitochondrial (SIRT3) Protein

Product specifications

Proteins and Peptides

NAD-Dependent Protein Deacetylase Sirtuin-3, Mitochondrial (SIRT3)

E. coli

Activity: Not tested
Sequence Fragment: Pro127-Glu303
Tag: N-terminal His tag

Rat

Unconjugated

Calculated MW: 20.8 kDa
Observed MW (SDS-PAGE): 22 kDa

Recombinant

> 95%

10 µg

50 µg

100 µg

200 µg

500 µg

Lyophilized

WB, SDS-PAGE

Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 5% Trehalose.

Shipped within 5-7 working days.

Store lyophilized form at 2-8°C for up to 1 month. For longer periods, store lyophilized or liquid at -80°C. Avoid repeated freeze–thaw cycles.

No

C6ZII9

SIR2L3,NAD-dependent protein deacetylase sirtuin-3 mitochondrial,SIR2-like protein 3,SIR2L3,hSIRT3

Protein SIRT3

RUO

THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION.
To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in 10 mM PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in 10 mM PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
Concentration: Prior to lyophilization: 500 µg/ml

Descripción

SIRT3 is a NAD+-dependent deacetylase primarily localized in the mitochondria, where it plays a critical role in regulating mitochondrial metabolism, energy production, and oxidative stress response SIRT3 deacetylates and activates key mitochondrial enzymes, including acetyl-CoA synthetase 2 (ACSS2), superoxide dismutase 2 (SOD2), and components of the electron transport chain, enhancing ATP production, fatty acid oxidation, and antioxidant defense SIRT3 is essential for maintaining mitochondrial homeostasis during energy stress, such as fasting or caloric restriction, by stimulating pathways that improve energy efficiency and reduce reactive oxygen species (ROS) levels SIRT3 also promotes cellular survival under oxidative stress by deacetylating SOD2, which neutralizes superoxide radicals Dysregulation of SIRT3 is associated with aging, metabolic disorders, cardiovascular disease, and neurodegeneration, where impaired mitochondrial function leads to cellular damage and energy deficiency SIRT3 has tumor suppressor properties as it inhibits aerobic glycolysis (Warburg effect) in cancer cells by regulating key metabolic enzymes Its activation is being explored as a therapeutic strategy to combat mitochondrial dysfunction, improve metabolic health, and delay aging-related diseases

Related Products

NAD-Dependent Protein Deacetylase Sirtuin-3, Mitochondrial (SIRT3) Antibody

SIRT3 Antibody is a Rabbit Polyclonal against SIRT3.

Ver Producto

NAD-Dependent Protein Deacetylase Sirtuin-3, Mitochondrial (SIRT3) Antibody

NAD-Dependent Protein Deacetylase Sirtuin-3, Mitochondrial Antibody is a Goat Polyclonal antibody against NAD-Dependent Protein Deacetylase Sirtuin-3, Mitochondrial.

Ver Producto

Human NAD-Dependent Protein Deacetylase Sirtuin-3, Mitochondrial (SIRT3) CLIA Kit

Human NAD-Dependent Protein Deacetylase Sirtuin-3, Mitochondrial (SIRT3) Chemiluminescent Immunoassay (CLIA) Kit is a Sandwich Chemiluminescent Immunoassay (CLIA) Kit for use with Tissue homogenates, cell lysates and other biological fluids.

Ver Producto