SIRT3 Antibody is a Rabbit Polyclonal antibody against SIRT3. This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Two alternatively spliced transcript variants that encode different proteins have been described for this gene.
Sirtuins are a family of signaling proteins that play a crucial role in metabolic regulation. They are classified into two main types based on their enzymatic activities: mono-ADP-ribosyltransferases or deacylases. Sirtuins are involved in influencing a wide range of cellular processes, including aging, transcription, apoptosis, inflammation, and stress resistance. In humans, there are seven types of sirtuins known as SIRT1 through SIRT7. The first Sirtuin, Sir2, was initially discovered in yeast. SIRT3 is the major mitochondria NAD+-dependent deacetylase and is known for targeting mitochondrial proteins for lysine deacetylation. It plays a significant role in the adaptive response of mitochondria to stress.
Las sirtuinas son una familia de proteínas de señalización que desempeñan un papel crucial en la regulación metabólica. Se clasifican en dos tipos principales según su actividad enzimática: mono-ADP-ribosiltransferasas o desacilasas. Las sirtuinas influyen en una amplia gama de procesos celulares, incluidos el envejecimiento, la transcripción, la apoptosis, la inflamación y la resistencia al estrés. En los seres humanos, existen siete tipos de sirtuinas conocidas como SIRT1 a SIRT7. La primera Sirtuin, Sir2, se descubrió inicialmente en levaduras. SIRT3 es la principal desacetilasa dependiente de NAD+ de las mitocondrias y es conocida por apuntar a las proteínas mitocondriales para la desacetilación de la lisina. Desempeña un papel importante en la respuesta adaptativa de las mitocondrias al estrés.
Primary Antibodies
Polyclonal
Human, Mouse, Rat
Sirtuin 3 (SIRT3)
Rabbit
Unconjugated
Liquid
WB, IHC, IF/ICC
Purified by affinity chromatography.
PBS, pH 7.3, containing 0.05% Proclin-300, 50% glycerol.
20 µl
50 µl
100 µl
200 µl
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
SIRT3
No
Shipped within 5-10 working days.
SIR2L3,NAD-dependent protein deacetylase sirtuin-3 mitochondrial,SIR2-like protein 3,SIR2L3,hSIRT3
NP_036371.1
This product is for research use only.
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