Human Sirtuin 3 (SIRT3) ELISA Kit
proveedor
Abbexareference
abx153094Tested Applications
ELISAreactivity
Humanstatus
RUOclonality
Descripción
Human Sirtuin 3 (SIRT3) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human Sirtuin 3 concentrations in tissue homogenates, cell lysates and other biological fluids. This assay has high sensitivity and excellent specificity for detection of Sirtuin 3 (SIRT3)No significant cross-reactivity or interference between Sirtuin 3 (SIRT3) and analogues was observed.
Background
Sirtuins are a family of signaling proteins that play a crucial role in metabolic regulation. They are classified into two main types based on their enzymatic activities: mono-ADP-ribosyltransferases or deacylases. Sirtuins are involved in influencing a wide range of cellular processes, including aging, transcription, apoptosis, inflammation, and stress resistance. In humans, there are seven types of sirtuins known as SIRT1 through SIRT7. The first Sirtuin, Sir2, was initially discovered in yeast. SIRT3 is the major mitochondria NAD+-dependent deacetylase and is known for targeting mitochondrial proteins for lysine deacetylation. It plays a significant role in the adaptive response of mitochondria to stress.
Background
Las sirtuinas son una familia de proteínas de señalización que desempeñan un papel crucial en la regulación metabólica. Se clasifican en dos tipos principales según su actividad enzimática: mono-ADP-ribosiltransferasas o desacilasas. Las sirtuinas influyen en una amplia gama de procesos celulares, incluidos el envejecimiento, la transcripción, la apoptosis, la inflamación y la resistencia al estrés. En los seres humanos, existen siete tipos de sirtuinas conocidas como SIRT1 a SIRT7. La primera Sirtuin, Sir2, se descubrió inicialmente en levaduras. SIRT3 es la principal desacetilasa dependiente de NAD+ de las mitocondrias y es conocida por apuntar a las proteínas mitocondriales para la desacetilación de la lisina. Desempeña un papel importante en la respuesta adaptativa de las mitocondrias al estrés.
Características del producto
category
ELISA Kits
immunogen target
Sirtuin 3 (SIRT3)
reactivity
Human
test range
0.156 ng/ml - 10 ng/ml
sensitivity
< 0.061 ng/ml
assay type
Sandwich
assay data
Quantitative
detection method
Colorimetric
sample type
Tissue homogenates,Cell lysates,Other biological fluids
size 1
96 tests
size 2
5 × 96 tests
size 3
10 × 96 tests
alias
SIR2L3,NAD-dependent protein deacetylase sirtuin-3 mitochondrial,SIR2-like protein 3,SIR2L3,hSIRT3
storage
Enviado a 4 °C. Una vez recibido, almacene el kit de acuerdo con las instrucciones citadas en el manual del kit
or code
SIRT3
dry ice
No
uniprot id
note
This product is for research use only. <p></p> The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. <p></p> Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
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