KHDRBS - KH RNA binding domain containing, signal transduction associated | Elisa - Clia - Antibody - Protein

Family main features

Background

KHDRBS (KH RNA Binding Domain Containing, Signal Transduction Associated) proteins are a family of RNA-binding proteins that play significant roles in post-transcriptional regulation of gene expression and signal transduction. These proteins are characterized by the presence of one or more K homology (KH) domains, which are responsible for binding RNA. The KHDRBS family includes members such as KHDRBS1 (also known as Sam68), KHDRBS2 (SLM-1), and KHDRBS3 (SLM-2). These proteins are involved in various cellular processes, including RNA splicing, mRNA transport, stability, and translation, and they interact with signaling pathways to regulate cell proliferation, differentiation, and apoptosis.

Protein Structure

KHDRBS proteins share common structural features that enable their functions:

KH Domains: These RNA-binding domains are critical for recognizing and binding to specific RNA sequences. KH domains facilitate the interaction of KHDRBS proteins with their RNA targets, influencing various aspects of RNA metabolism.
Proline-Rich Regions: These regions are involved in protein-protein interactions, enabling KHDRBS proteins to function as adaptors in signaling pathways.
Tyrosine-Rich Regions: These regions can be phosphorylated, providing regulatory control over the protein's activity and interactions.

Classification and Subtypes

The KHDRBS protein family includes several members, each with distinct roles and tissue-specific expressions:

KHDRBS1 (Sam68): Widely expressed and involved in multiple cellular processes, including RNA splicing, translation, and signal transduction.
KHDRBS2 (SLM-1): Primarily expressed in the brain and testes, playing roles in neuronal and germ cell functions.
KHDRBS3 (SLM-2): Similar to KHDRBS2, with roles in RNA processing and signal transduction in specific tissues.

Function and Biological Significance

KHDRBS proteins are involved in several key cellular processes:

RNA Splicing: KHDRBS proteins regulate alternative splicing of pre-mRNAs, influencing the diversity of protein isoforms produced within cells. This regulation is critical for cellular differentiation and response to external stimuli.
mRNA Transport and Stability: By binding to specific RNA sequences, KHDRBS proteins can influence the localization, stability, and translation of mRNAs, thereby regulating gene expression post-transcriptionally.
Signal Transduction: KHDRBS proteins interact with signaling molecules and pathways, such as the PI3K/Akt and MAPK pathways, integrating RNA processing with cellular signaling networks.
Cell Proliferation and Apoptosis: Through their roles in RNA metabolism and signaling, KHDRBS proteins regulate cell proliferation, differentiation, and apoptosis, contributing to tissue development and homeostasis.

Clinical Issues

Alterations in KHDRBS function or expression are associated with various diseases:

Cancer: Dysregulation of KHDRBS proteins, particularly Sam68, has been implicated in several cancers. Overexpression or mutations can lead to aberrant RNA processing and signaling, promoting tumorigenesis and cancer progression.
Neurological Disorders: Given their roles in neuronal RNA processing, mutations or dysregulation of KHDRBS proteins can contribute to neurodegenerative diseases and other neurological conditions.
Reproductive Disorders: KHDRBS proteins involved in germ cell function are critical for fertility. Dysregulation can lead to reproductive issues, including infertility.

Summary

KHDRBS (KH RNA Binding Domain Containing, Signal Transduction Associated) proteins are crucial RNA-binding proteins involved in post-transcriptional regulation and signal transduction. Featuring KH domains for RNA binding and proline- and tyrosine-rich regions for protein interactions, KHDRBS proteins regulate RNA splicing, mRNA transport, stability, and translation. They also integrate with signaling pathways to control cell proliferation, differentiation, and apoptosis. Dysregulation of KHDRBS proteins is associated with cancer, neurological disorders, and reproductive issues. Understanding the roles and mechanisms of KHDRBS proteins in cellular processes is vital for developing therapeutic strategies for these conditions.

KHDRBS1 Recommended name:

KH RNA binding domain containing, signal transduction associated 1 (KHDRBS1)

Aliases for KHDRBS1

Sam68, p62, p68,Src-associated in mitosis 68 kDa protein,GAP-associated tyrosine phosphoprotein p62

KHDRBS2 Recommended name:

KH RNA binding domain containing, signal transduction associated 2 (KHDRBS2)

Aliases for KHDRBS2

KHDRBS2-OT, KHDRBS2-OT1, SLM-1, SLM1,Sam68-like mammalian protein 1

KHDRBS3 Recommended name:

KH RNA binding domain containing, signal transduction associated 3 (KHDRBS3)

Aliases for KHDRBS3

Etle, SALP, SLM-2, SLM2, T-STAR, TSTAR, etoile,RNA-binding protein T-Star

En la tabla siguiente se muestra una comparativa de todos los reactivos disponibles en nuestro catálogo (Proteins and Peptides, ELISA Kits, Primary Antibodies) relacionados con KHDRBS - KH RNA binding domain containing, signal transduction associated

Se muestran ordenados por categorías para poder comparar cómodamente sus características principales. Esta tabla, que contiene un enlace con la ficha de cada producto, es exportable a Excel.

Esta página contiene 29 reactivos de las marcas (Abbexa, FineTest) que se corresponden con tu busqueda

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immunoassays

provider	Code	reference	name	reactivity	sample type	assay type	test range	sensitivity	price	size 1	uniprot id	status
Abbexa	KHDRBS1	abx385068	Human GAP-Associated Tyrosine Phosphoprotein P62 (KHDRBS1) ELISA Kit	Human	Tissue homogenates,Cell lysates,Other biological fluids	Sandwich	0.156 ng/ml - 10 ng/ml	< 0.094 ng/ml	687.5	96 tests	Q07666	RUO
Abbexa	KHDRBS2	abx529903	Human KH domain-containing, RNA-binding, signal transduction-associated protein 2 (KHDRBS2) ELISA Kit	Human	Tissue homogenates,Cell lysates,Other biological fluids		0.156 ng/ml - 10 ng/ml		687.5	96 tests	Q5VWX1	RUO
Abbexa	KHDRBS3	abx388113	Human RNA-Binding Protein T-Star (KHDRBS3) ELISA Kit	Human	Tissue homogenates,Cell lysates,Other biological fluids	Sandwich	0.156 ng/ml - 10 ng/ml	< 0.094 ng/ml	687.5	96 tests	O75525	RUO
Abbexa	KHDRBS1	abx389688	Mouse GAP-Associated Tyrosine Phosphoprotein P62 (KHDRBS1) ELISA Kit	Mouse	Tissue homogenates,Cell lysates,Other biological fluids	Sandwich	78 pg/ml - 5000 pg/ml	< 46.9 pg/ml	687.5	96 tests	Q60749	RUO
Abbexa	KHDRBS2	abx529904	Mouse KH domain-containing, RNA-binding, signal transduction-associated protein 2 (KHDRBS2) ELISA Kit	Mouse	Tissue homogenates,Cell lysates,Other biological fluids		0.156 ng/ml - 10 ng/ml		687.5	96 tests	Q9WU01	RUO
Abbexa	KHDRBS3	abx529907	Mouse KH domain-containing, RNA-binding, signal transduction-associated protein 3 (KHDRBS3) ELISA Kit	Mouse	Tissue homogenates,Cell lysates,Other biological fluids		0.156 ng/ml - 10 ng/ml		687.5	96 tests	Q9R226	RUO
Abbexa	KHDRBS1	abx391526	Rat GAP-Associated Tyrosine Phosphoprotein P62 (KHDRBS1) ELISA Kit	Rat	Tissue homogenates,Cell lysates,Other biological fluids	Sandwich	78 pg/ml - 5000 pg/ml	< 46.9 pg/ml	687.5	96 tests	Q91V33	RUO
Abbexa	KHDRBS2	abx529905	Rat KH Domain-Containing, RNA-Binding, Signal Transduction-Associated Protein 2 (KHDRBS2) ELISA Kit	Rat	Tissue homogenates,Cell lysates,Other biological fluids		0.156 ng/ml - 10 ng/ml		687.5	96 tests	Q920F3	RUO
Abbexa	KHDRBS3	abx529908	Rat RNA-Binding Protein T-Star (KHDRBS3) ELISA Kit	Rat	Tissue homogenates,Cell lysates,Other biological fluids		0.156 ng/ml - 10 ng/ml		687.5	96 tests	Q9JLP1	RUO

Primary Antibodies

provider	Code	reference	name	reactivity	clonality	host	immunogen target	isotype	conjugation	tested applications	price	size 1	uniprot id	status
FineTest	KHDRBS1	FNab07585	anti- Sam68 antibody	human	polyclonal	Rabbit	KH domain containing, RNA binding, signal transduction associated 1	IgG	Unconjugated	ELISA, WB, IHC, IF, FC, IP		100µg	Q07666	RUO
FineTest	KHDRBS3	FNab04523	anti- KHDRBS3 antibody	human	polyclonal	Rabbit	KH domain containing, RNA binding, signal transduction associated 3	IgG	Unconjugated	ELISA, WB, IHC		100µg	O75525	RUO
Abbexa	KHDRBS1	abx128380	KH Domain Containing, RNA Binding, Signal Transduction Associated Protein 1 (KHDRBS1) Antibody	Human	Polyclonal	Rabbit	KH Domain Containing, RNA Binding, Signal Transduction Associated Protein 1 (KHDRBS1)		Unconjugated	WB, IHC, IF/ICC	287.5	100 µl		RUO
Abbexa	KHDRBS1	abx113354	GAP-Associated Tyrosine Phosphoprotein P62 (KHDRBS1) Antibody	Human	Polyclonal	Rabbit	GAP-Associated Tyrosine Phosphoprotein P62 (KHDRBS1)		Unconjugated	ELISA, WB, IHC, IF/ICC	612.5	100 µl	Q07666	RUO
Abbexa	KHDRBS1	abx007308	GAP-Associated Tyrosine Phosphoprotein P62 (KHDRBS1) Antibody	Human	Polyclonal	Rabbit	GAP-Associated Tyrosine Phosphoprotein P62 (KHDRBS1)		Unconjugated	WB, IHC, IF/ICC	175	20 µl	Q07666	RUO
Abbexa	KHDRBS1	abx237585	Sam68 Antibody	Human	Polyclonal	Rabbit	Sam68		Unconjugated	ELISA, WB, IHC, IF/ICC, FCM, IP	350	100 µg	Q07666	RUO
Abbexa	KHDRBS1	abx327286	KH Domain Containing, RNA Binding, Signal Transduction Associated Protein 1 (KHDRBS1) Antibody	Human	Polyclonal	Rabbit	KH Domain Containing, RNA Binding, Signal Transduction Associated Protein 1 (KHDRBS1)		Unconjugated	ELISA, WB	187.5	50 µg	Q07666	RUO
Abbexa	KHDRBS2	abx307678	KH Domain-Containing, RNA-Binding, Signal Transduction-Associated Protein 2 (KHDRBS2) Antibody	Human	Polyclonal	Rabbit	KH Domain-Containing, RNA-Binding, Signal Transduction-Associated Protein 2 (KHDRBS2)		Unconjugated	ELISA, WB, IHC	162.5	20 µg	Q5VWX1	RUO
Abbexa	KHDRBS2	abx224066	KH Domain-Containing, RNA-Binding, Signal Transduction-Associated Protein 2 (KHDRBS2) Antibody	Human	Monoclonal	Mouse	KH Domain-Containing, RNA-Binding, Signal Transduction-Associated Protein 2 (KHDRBS2)			ELISA, WB, IHC, FCM	362.5	100 µl		RUO
Abbexa	KHDRBS2	abx007227	KH Domain-Containing, RNA-Binding, Signal Transduction-Associated Protein 2 (KHDRBS2) Antibody	Human	Polyclonal	Rabbit	KH Domain-Containing, RNA-Binding, Signal Transduction-Associated Protein 2 (KHDRBS2)		Unconjugated	WB, IHC	175	20 µl	Q5VWX1	RUO
Abbexa	KHDRBS2	abx034990	KH Domain-Containing, RNA-Binding, Signal Transduction-Associated Protein 2 (KHDRBS2) Antibody	Human	Polyclonal	Rabbit	KH Domain-Containing, RNA-Binding, Signal Transduction-Associated Protein 2 (KHDRBS2)		Unconjugated	ELISA, WB	281.25	80 µl	Q5VWX1	RUO
Abbexa	KHDRBS3	abx030741	RNA-Binding Protein T-Star (KHDRBS3) Antibody	Human	Polyclonal	Rabbit	RNA-Binding Protein T-Star (KHDRBS3)		Unconjugated	ELISA, WB	250	80 µl	O75525	RUO
Abbexa	KHDRBS3	abx320740	RNA-Binding Protein T-Star (KHDRBS3) Antibody	Human	Polyclonal	Rabbit	RNA-Binding Protein T-Star (KHDRBS3)		Unconjugated	ELISA, IHC	250	50 µl	O75525	RUO
Abbexa	KHDRBS3	abx005088	RNA-Binding Protein T-Star (KHDRBS3) Antibody	Human	Polyclonal	Rabbit	RNA-Binding Protein T-Star (KHDRBS3)		Unconjugated	WB, IF/ICC	175	20 µl	O75525	RUO
Abbexa	KHDRBS3	abx234523	RNA-Binding Protein T-Star (KHDRBS3) Antibody	Human	Polyclonal	Rabbit	RNA-Binding Protein T-Star (KHDRBS3)		Unconjugated	ELISA, WB, IHC	350	100 µg	O75525	RUO
Abbexa	KHDRBS3	abx113355	RNA-Binding Protein T-Star (KHDRBS3) Antibody	Human	Polyclonal	Rabbit	RNA-Binding Protein T-Star (KHDRBS3)		Unconjugated	ELISA, WB, IHC	612.5	100 µl	O75525	RUO
Abbexa	KHDRBS1	abx030956	Mouse Khdrbs1 Antibody	Mouse	Polyclonal	Rabbit	Mouse Khdrbs1		Unconjugated	ELISA, WB	281.25	80 µl	Q60749	RUO
Abbexa	KHDRBS1	abx104762	KH Domain Containing, RNA Binding, Signal Transduction Associated Protein 1 (KHDRBS1) Antibody	Mouse	Polyclonal	Rabbit	KH Domain Containing, RNA Binding, Signal Transduction Associated Protein 1 (KHDRBS1)		Unconjugated	WB, IHC, IF/ICC	287.5	100 µl		RUO

Proteins and Peptides

provider	Code	reference	name	origin	expression	host	conjugation	tested applications	price	size 1	uniprot id	status
Abbexa	KHDRBS1	abx067639	Mouse KH Domain Containing, RNA Binding, Signal Transduction Associated Protein 1 (KHDRBS1) Protein	Mouse		E. coli	Unconjugated	WB, SDS-PAGE	225	10 µg	Q60749	RUO
Abbexa	KHDRBS1	abx166241	Human KH Domain Containing, RNA Binding, Signal Transduction Associated Protein 1 (KHDRBS1) Protein	Human	Recombinant	E. coli	Unconjugated	WB, SDS-PAGE	225	10 µg		RUO

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