GAP-Associated Tyrosine Phosphoprotein P62 (KHDRBS1) Antibody
312€ (60 µl)
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935106861
info@markelab.com
name
GAP-Associated Tyrosine Phosphoprotein P62 (KHDRBS1) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx007308
tested applications
WB, IHC, IF/ICC
Description
KHDRBS1 Antibody is a Rabbit Polyclonal Antibody against KHDRBS1.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | GAP-Associated Tyrosine Phosphoprotein P62 (KHDRBS1) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1/500 - 1/2000, IHC-P: 1/100 - 1/200, IF/ICC: 1/50 - 1/200. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by affinity chromatography. |
| Size 1 | 60 µl |
| Size 2 | 120 µl |
| Size 3 | 200 µl |
| Form | Liquid |
| Tested Applications | WB, IHC, IF/ICC |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q07666 |
| Gene ID | 10657 |
| NCBI Accession | NP_006550.1 |
| Alias | Sam68, p62, p68,Src-associated in mitosis 68 kDa protein,GAP-associated tyrosine phosphoprotein p62 |
| Background | Antibody anti-KHDRBS1 |
| Status | RUO |
| Note | Concentration: 1 mg/ml - |
Descripción
KHDRBS1, also known as Sam68 (Src-associated in mitosis, 68 kDa), is an RNA-binding protein that contains a KH (hnRNP K homology) domain, enabling it to regulate RNA processing, splicing, and translation. It interacts with signaling proteins such as Src and is involved in linking signal transduction pathways to RNA metabolism. KHDRBS1 plays roles in cell cycle progression, proliferation, and apoptosis, particularly during mitosis, where it is phosphorylated by Src kinases. It is expressed in multiple tissues, particularly in proliferating cells and neurons, and regulates mRNA stability and alternative splicing of key genes like BCL2 and CD44. Dysregulation of KHDRBS1 is associated with cancers, including breast and prostate cancer, where it promotes tumor progression and metastasis by modulating RNA processing of oncogenic transcripts. Knockdown studies reveal defects in cell division, proliferation, and stress responses, highlighting its dual role in signal transduction and RNA regulation.
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