Human GAP-Associated Tyrosine Phosphoprotein P62 (KHDRBS1) ELISA Kit
715€ (96 tests)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
935106861
info@markelab.com
name
Human GAP-Associated Tyrosine Phosphoprotein P62 (KHDRBS1) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx385068
tested applications
ELISA
Description
Human GAP-Associated Tyrosine Phosphoprotein P62 (KHDRBS1) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human KHDRBS1 concentrations in tissue homogenates, cell lysates and other biological fluids.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | ELISA Kits |
| Immunogen Target | GAP-Associated Tyrosine Phosphoprotein P62 (KHDRBS1) |
| Reactivity | Human |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Assay Type | Sandwich |
| Test Range | 0.156 ng/ml - 10 ng/ml |
| Sensitivity | < 0.094 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-12 working days. The validity for this kit is 6 months. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | Q07666 |
| Gene ID | 10657 |
| OMIM | 602489 |
| Alias | Sam68, p62, p68,Src-associated in mitosis 68 kDa protein,GAP-associated tyrosine phosphoprotein p62 |
| Background | Elisa kits for KHDRBS1 |
| Status | RUO |
| Note | Validity: The validity for this kit is 6 months. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
KHDRBS1, also known as Sam68 (Src-associated in mitosis, 68 kDa), is an RNA-binding protein that contains a KH (hnRNP K homology) domain, enabling it to regulate RNA processing, splicing, and translation. It interacts with signaling proteins such as Src and is involved in linking signal transduction pathways to RNA metabolism. KHDRBS1 plays roles in cell cycle progression, proliferation, and apoptosis, particularly during mitosis, where it is phosphorylated by Src kinases. It is expressed in multiple tissues, particularly in proliferating cells and neurons, and regulates mRNA stability and alternative splicing of key genes like BCL2 and CD44. Dysregulation of KHDRBS1 is associated with cancers, including breast and prostate cancer, where it promotes tumor progression and metastasis by modulating RNA processing of oncogenic transcripts. Knockdown studies reveal defects in cell division, proliferation, and stress responses, highlighting its dual role in signal transduction and RNA regulation.
Related Products
anti- Sam68 antibody
Ver Producto
GAP-Associated Tyrosine Phosphoprotein P62 (KHDRBS1) Antibody
KHDRBS1 Antibody is a Rabbit Polyclonal Antibody against KHDRBS1.
Ver Producto
Mouse Khdrbs1 Antibody
Recruited and tyrosine phosphorylated by several receptor systems, for example the T-cell, leptin and insulin receptors. Once phosphorylated, functions as an adapter protein in signal transduction cascades by binding to SH2 and SH3 domain-containing proteins. Role in G2-M progression in the cell cycle. Represses CBP-dependent transcriptional activation apparently by competing with other nuclear factors for binding to CBP. Also acts as a putative regulator of mRNA stability and/or translation rates and mediates mRNA nuclear export.
Ver Producto