RNA-Binding Protein T-Star (KHDRBS3) Antibody
292.5€ (80 µl)
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Name
RNA-Binding Protein T-Star (KHDRBS3) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx030741
Tested Applications
ELISA, WB
Description
RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion. May play a role as a negative regulator of cell growth. Inhibits cell proliferation. Involved in splice site selection of vascular endothelial growth factor. Induces an increased concentration-dependent incorporation of exon in CD44 pre-mRNA by direct binding to purine-rich exonic enhancer. RNA-binding abilities are down-regulated by tyrosine kinase PTK6. Involved in post-transcriptional regulation of HIV-1 gene expression.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: RNA-Binding Protein T-Star (KHDRBS3) Immunogen: KLH-conjugated synthetic peptide between 18-47 amino acids from the N-terminal region of human KHDRBS3. |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | Calculated MW: 38.8 kDa |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Size 1 | 80 µl |
| Size 2 | 400 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | O75525 |
| Alias | Etle, SALP, SLM-2, SLM2, T-STAR, TSTAR, etoile,RNA-binding protein T-Star |
| Background | Antibody anti-KHDRBS3 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
KHDRBS3, also known as T-STAR (testis-signal transduction and activation of RNA), is a member of the Sam68 family of KH-domain RNA-binding proteins. It regulates alternative splicing, RNA transport, and translation, linking RNA processing to cellular signaling pathways. KHDRBS3 is highly expressed in the testis and brain, where it regulates spermatogenesis, synaptic plasticity, and germ cell development. It interacts with signaling proteins, including tyrosine kinases, and is involved in cell cycle control, meiosis, and differentiation. Dysregulation of KHDRBS3 is associated with infertility and neurological disorders due to defects in RNA metabolism and cellular differentiation. Knockout studies show impaired germ cell development and reduced neuronal plasticity, highlighting its critical role in tissue-specific gene expression and RNA regulation.
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