KH Domain Containing, RNA Binding, Signal Transduction Associated Protein 1 (KHDRBS1) Antibody
221€ (50 µg)
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Name
KH Domain Containing, RNA Binding, Signal Transduction Associated Protein 1 (KHDRBS1) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx327286
Tested Applications
ELISA, WB
Description
KHDRBS1 Antibody is a Rabbit Polyclonal against KHDRBS1.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: KH Domain Containing, RNA Binding, Signal Transduction Associated Protein 1 (KHDRBS1) Immunogen: Synthesized peptide derived from the Internal region of human Sam 68. |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | ELISA: 1/10000, WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by affinity chromatography. |
| Size 1 | 50 µg |
| Size 2 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q07666 |
| Gene ID | 10657 |
| Alias | Sam68, p62, p68,Src-associated in mitosis 68 kDa protein,GAP-associated tyrosine phosphoprotein p62 |
| Background | Antibody anti-KHDRBS1 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
KHDRBS1, also known as Sam68 (Src-associated in mitosis, 68 kDa), is an RNA-binding protein that contains a KH (hnRNP K homology) domain, enabling it to regulate RNA processing, splicing, and translation. It interacts with signaling proteins such as Src and is involved in linking signal transduction pathways to RNA metabolism. KHDRBS1 plays roles in cell cycle progression, proliferation, and apoptosis, particularly during mitosis, where it is phosphorylated by Src kinases. It is expressed in multiple tissues, particularly in proliferating cells and neurons, and regulates mRNA stability and alternative splicing of key genes like BCL2 and CD44. Dysregulation of KHDRBS1 is associated with cancers, including breast and prostate cancer, where it promotes tumor progression and metastasis by modulating RNA processing of oncogenic transcripts. Knockdown studies reveal defects in cell division, proliferation, and stress responses, highlighting its dual role in signal transduction and RNA regulation.
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