Family main features
CD28 is a pivotal co-stimulatory molecule expressed on the surface of T cells. It plays a crucial role in the activation and survival of T cells, which are essential components of the adaptive immune system. CD28 is predominantly found on CD4+ T helper cells, although it is also present on a subset of CD8+ cytotoxic T cells. The interaction of CD28 with its ligands, CD80 (B7-1) and CD86 (B7-2), on antigen-presenting cells (APCs) provides the necessary secondary signals that, together with signals from the T cell receptor (TCR), lead to full T cell activation, proliferation, and differentiation. The presence and function of CD28 are vital for initiating effective immune responses and for maintaining T cell homeostasis and tolerance.
The CD28 molecule is a homodimeric glycoprotein, each monomer comprising several distinct structural domains:
Extracellular Domain:
Transmembrane Domain:
Cytoplasmic Tail:
CD28 does not have multiple subtypes like some other cell surface molecules. However, it functions in concert with various co-stimulatory and inhibitory receptors, forming part of a broader family of immune regulatory proteins. Its primary ligands, CD80 and CD86, are expressed on APCs, and their interaction with CD28 is essential for the co-stimulation required for T cell activation.
T Cell Activation:
Cytokine Production:
Regulation of Immune Responses:
Costimulation and Immune Checkpoints:
Autoimmune Diseases:
Cancer Immunotherapy:
Transplantation:
Infectious Diseases:
The CD28 molecule is a cornerstone of T cell activation and immune regulation. Its structure, comprising extracellular, transmembrane, and cytoplasmic domains, allows it to interact with ligands CD80 and CD86 on APCs, providing crucial co-stimulatory signals for T cell activation. CD28 signaling enhances cytokine production, promotes T cell proliferation, and helps maintain immune tolerance. Clinically, CD28 is significant in autoimmunity, cancer immunotherapy, transplantation, and infectious diseases. Therapeutic modulation of CD28 signaling, through agents like CTLA-4-Ig fusion proteins, offers promising avenues for treating various immune-related conditions. Understanding CD28's roles and mechanisms is essential for developing targeted immunotherapies and improving immune regulation strategies.
CD28 molecule (CD28)
Tp44,T-cell-specific surface glycoprotein CD28
En la tabla siguiente se muestra una comparativa de todos los reactivos disponibles en nuestro catálogo (Proteins and Peptides, ELISA Kits, Primary Antibodies) relacionados con CD28 molecule
Se muestran ordenados por categorías para poder comparar cómodamente sus características principales. Esta tabla, que contiene un enlace con la ficha de cada producto, es exportable a Excel.
Esta página contiene 60 reactivos de las marcas (Abbexa, FineTest) que se corresponden con tu busqueda
Contacta con nosotros en info@markelab.com, si necesitas mas informacion o alguna aclaracion. Te garantizamos respuesta en menos de 24 h.
provider | Code | reference | name | reactivity | sample type | assay type | test range | sensitivity | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | CD28 | abx356685 | Chicken T-Cell-Specific Surface Glycoprotein CD28 (CD28) ELISA Kit | Chicken | Serum,Plasma,Other biological fluids | Sandwich | 3.125 ng/ml - 200 ng/ml | 1.88 ng/ml | 662.5 | 96 tests | RUO | |
Abbexa | CD28 | abx513614 | Cow T-Cell-Specific Surface Glycoprotein CD28 (CD28) ELISA Kit | Cow | Tissue homogenates,Cell lysates,Other biological fluids | 0.156 ng/ml - 10 ng/ml | 687.5 | 96 tests | Q28071 | RUO | ||
FineTest | CD28 | EH0653 | Human CD28(T-cell-specific surface glycoprotein CD28) ELISA Kit | human | Serum,Plasma,Tissue homogenates,Other biological fluids | Sandwich ELISA, Double Antibody | 0.625-40ng/ml | 96T | P10747 | RUO | ||
Abbexa | CD28 | abx253617 | Human T-Cell-Specific Surface Glycoprotein CD28 (CD28) ELISA Kit | Human | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 0.625 ng/ml - 40 ng/ml | 0.38 ng/ml | 525 | 96 tests | P10747 | RUO |
Abbexa | CD28 | abx359480 | Monkey T-Cell-Specific Surface Glycoprotein CD28 (CD28) ELISA Kit | Monkey | Serum,Plasma,Other biological fluids | Sandwich | 0.625 ng/ml - 40 ng/ml | 0.38 ng/ml | 662.5 | 96 tests | RUO | |
FineTest | CD28 | EM1874 | Mouse CD28(Cluster of Differentiation 28) ELISA Kit | mouse | Busacar en las instrucciones | Sandwich ELISA, Double Antibody | 0.156-10ng/ml | 96T | P31041 | RUO | ||
Abbexa | CD28 | abx513617 | Mouse T-Cell-Specific Surface Glycoprotein CD28 (CD28) ELISA Kit | Mouse | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 0.625 ng/ml - 40 ng/ml | < 0.325 ng/ml | 537.5 | 96 tests | P31041 | RUO |
Abbexa | CD28 | abx363245 | Rabbit T-Cell-Specific Surface Glycoprotein CD28 (CD28) ELISA Kit | Rabbit | Serum,Plasma,Other biological fluids | Sandwich | 3.125 ng/ml - 200 ng/ml | 1.88 ng/ml | 662.5 | 96 tests | RUO | |
FineTest | CD28 | ER0814 | Rat CD28(Cluster of Differentiation 28) ELISA Kit | rat | Serum,Plasma,Tissue homogenates,Other biological fluids | Sandwich ELISA, Double Antibody | 0.313-20ng/ml | 96T | P31042 | RUO | ||
Abbexa | CD28 | abx256782 | Rat T-Cell-Specific Surface Glycoprotein CD28 (CD28) ELISA Kit | Rat | Serum,Plasma,Other biological fluids | Sandwich | 0.312 ng/ml - 20 ng/ml | 0.19 ng/ml | 562.5 | 96 tests | G3V7C2 | RUO |
provider | Code | reference | name | reactivity | clonality | host | immunogen target | isotype | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | CD28 | abx415189 | T-Cell-Specific Surface Glycoprotein CD28 (CD28) Antibody (PE) | Cow | Monoclonal | Mouse | T-Cell-Specific Surface Glycoprotein CD28 (CD28) | PE | FCM | 637.5 | 100 tests | Q28071 | RUO | |
Abbexa | CD28 | abx033096 | T-Cell-Specific Surface Glycoprotein CD28 (CD28) Antibody | Human | Polyclonal | Rabbit | T-Cell-Specific Surface Glycoprotein CD28 (CD28) | Unconjugated | ELISA, WB, IF/ICC | 250 | 80 µl | P10747 | RUO | |
Abbexa | CD28 | abx229429 | T-Cell-Specific Surface Glycoprotein CD28 (CD28) Antibody (FITC) | Human | Monoclonal | Mouse | T-Cell-Specific Surface Glycoprotein CD28 (CD28) | IgG1 Kappa | FITC | FCM | 62.5 | 20 tests | P10747 | RUO |
Abbexa | CD28 | abx831586 | CD28 Antibody | Human | Monoclonal | Human | CD28 | Unconjugated | ELISA, WB | 387.5 | 100 µg | RUO | ||
Abbexa | CD28 | abx229430 | T-Cell-Specific Surface Glycoprotein CD28 (CD28) Antibody (PE) | Human | Monoclonal | Mouse | T-Cell-Specific Surface Glycoprotein CD28 (CD28) | IgG1 Kappa | PE | FCM | 75 | 20 tests | P10747 | RUO |
Abbexa | CD28 | abx432468 | T-Cell-Specific Surface Glycoprotein CD28 (CD28) Antibody | Human | Polyclonal | Goat | T-Cell-Specific Surface Glycoprotein CD28 (CD28) | Unconjugated | P-ELISA, WB, IHC | 387.5 | 200 µl | RUO | ||
Abbexa | CD28 | abx415422 | T-Cell-Specific Surface Glycoprotein CD28 (CD28) Antibody (PE) | Human | Monoclonal | Rat | T-Cell-Specific Surface Glycoprotein CD28 (CD28) | PE | FCM | 487.5 | 100 tests | P10747 | RUO | |
Abbexa | CD28 | abx323652 | T-Cell-Specific Surface Glycoprotein CD28 (CD28) Antibody | Human | Polyclonal | Rabbit | T-Cell-Specific Surface Glycoprotein CD28 (CD28) | Unconjugated | ELISA, WB | 187.5 | 50 µg | P10747 | RUO | |
Abbexa | CD28 | abx229428 | T-Cell-Specific Surface Glycoprotein CD28 (CD28) Antibody | Human | Monoclonal | Mouse | T-Cell-Specific Surface Glycoprotein CD28 (CD28) | IgG1 Kappa | Unconjugated | IHC, FCM, IP | 100 | 50 µg | P10747 | RUO |
Abbexa | CD28 | abx229431 | T-Cell-Specific Surface Glycoprotein CD28 (CD28) Antibody (APC) | Human | Monoclonal | Mouse | T-Cell-Specific Surface Glycoprotein CD28 (CD28) | IgG1 Kappa | APC | FCM | 75 | 20 tests | P10747 | RUO |
Abbexa | CD28 | abx347094 | T-Cell-Specific Surface Glycoprotein CD28 (CD28) Antibody (PerCP / Cyanine 5.5) | Human | Monoclonal | Mouse | T-Cell-Specific Surface Glycoprotein CD28 (CD28) | PerCP / Cyanine 5.5 | FCM | 562.5 | 100 tests | P10747 | RUO | |
Abbexa | CD28 | abx139217 | T-Cell-Specific Surface Glycoprotein CD28 (CD28) Antibody (PE) | Human | Monoclonal | Mouse | T-Cell-Specific Surface Glycoprotein CD28 (CD28) | PE | FCM | 400 | 100 tests | P10747 | RUO | |
Abbexa | CD28 | abx140988 | T-Cell-Specific Surface Glycoprotein CD28 (CD28) Antibody (APC / Cyanine 7) | Human | Monoclonal | Mouse | T-Cell-Specific Surface Glycoprotein CD28 (CD28) | APC / Cyanine 7 | FCM | 437.5 | 100 tests | P10747 | RUO | |
Abbexa | CD28 | abx139216 | T-Cell-Specific Surface Glycoprotein CD28 (CD28) Antibody (PerCP) | Human | Monoclonal | Mouse | T-Cell-Specific Surface Glycoprotein CD28 (CD28) | PerCP | FCM | 400 | 100 tests | P10747 | RUO | |
Abbexa | CD28 | abx139215 | T-Cell-Specific Surface Glycoprotein CD28 (CD28) Antibody | Human | Monoclonal | Mouse | T-Cell-Specific Surface Glycoprotein CD28 (CD28) | Unconjugated | WB, IHC-F, IF/ICC, FCM, IP, FUNC | 275 | 0.1 mg | P10747 | RUO | |
Abbexa | CD28 | abx139214 | T-Cell-Specific Surface Glycoprotein CD28 (CD28) Antibody | Human | Monoclonal | Mouse | T-Cell-Specific Surface Glycoprotein CD28 (CD28) | Unconjugated | WB, IHC-F, IF/ICC, FCM, IP | 275 | 0.1 mg | P10747 | RUO | |
Abbexa | CD28 | abx140933 | T-Cell-Specific Surface Glycoprotein CD28 (CD28) Antibody (APC / Cyanine 7) | Human | Monoclonal | Mouse | T-Cell-Specific Surface Glycoprotein CD28 (CD28) | APC / Cyanine 7 | FCM | 437.5 | 100 tests | P10747 | RUO | |
Abbexa | CD28 | abx139219 | T-Cell-Specific Surface Glycoprotein CD28 (CD28) Antibody (FITC) | Human | Monoclonal | Mouse | T-Cell-Specific Surface Glycoprotein CD28 (CD28) | FITC | FCM | 350 | 100 tests | P10747 | RUO | |
Abbexa | CD28 | abx139218 | T-Cell-Specific Surface Glycoprotein CD28 (CD28) Antibody (APC) | Human | Monoclonal | Mouse | T-Cell-Specific Surface Glycoprotein CD28 (CD28) | APC | FCM | 400 | 100 tests | P10747 | RUO | |
Abbexa | CD28 | abx325546 | T-Cell-Specific Surface Glycoprotein CD28 Phospho-Tyr218 (CD28 pY218) Antibody | Human | Polyclonal | Rabbit | T-Cell-Specific Surface Glycoprotein CD28 Phospho-Tyr218 (CD28 pY218) | Unconjugated | ELISA, WB | 187.5 | 50 µg | P10747 | RUO | |
Abbexa | CD28 | abx270953 | T-Cell-Specific Surface Glycoprotein CD28 (CD28) Antibody (PE) | Mouse | Polyclonal | Rabbit | T-Cell-Specific Surface Glycoprotein CD28 (CD28) | PE | FCM | 687.5 | 200 tests | RUO | ||
Abbexa | CD28 | abx228277 | T-Cell-Specific Surface Glycoprotein CD28 (CD28) Antibody (FITC) | Mouse | Monoclonal | Hamster | T-Cell-Specific Surface Glycoprotein CD28 (CD28) | IgG | FITC | FCM | 43.75 | 20 tests | P31041 | RUO |
Abbexa | CD28 | abx137056 | T-Cell-Specific Surface Glycoprotein CD28 (CD28) Antibody | Mouse | Monoclonal | Hamster | T-Cell-Specific Surface Glycoprotein CD28 (CD28) | Unconjugated | 487.5 | 0.5 mg | RUO | |||
Abbexa | CD28 | abx137135 | T-Cell-Specific Surface Glycoprotein CD28 (CD28) Antibody (FITC) | Mouse | Monoclonal | Hamster | T-Cell-Specific Surface Glycoprotein CD28 (CD28) | FITC | 487.5 | 0.5 mg | RUO | |||
Abbexa | CD28 | abx129528 | T-Cell-Specific Surface Glycoprotein CD28 (CD28) Antibody | Mouse | Polyclonal | Rabbit | T-Cell-Specific Surface Glycoprotein CD28 (CD28) | Unconjugated | WB, IHC, IF/ICC | 262.5 | 100 µl | P31041 | RUO | |
Abbexa | CD28 | abx228274 | T-Cell-Specific Surface Glycoprotein CD28 (CD28) Antibody | Mouse | Monoclonal | Hamster | T-Cell-Specific Surface Glycoprotein CD28 (CD28) | IgG | Unconjugated | IHC, FCM, IP | 100 | 50 µg | P31041 | RUO |
Abbexa | CD28 | abx228275 | T-Cell-Specific Surface Glycoprotein CD28 (CD28) Antibody | Mouse | Monoclonal | Hamster | T-Cell-Specific Surface Glycoprotein CD28 (CD28) | IgG | Unconjugated | IHC, FCM, IP | 75 | 25 µg | P31041 | RUO |
Abbexa | CD28 | abx431150 | T-Cell-Specific Surface Glycoprotein CD28 (CD28) Antibody | Mouse | Polyclonal | Goat | T-Cell-Specific Surface Glycoprotein CD28 (CD28) | Unconjugated | P-ELISA, WB | 387.5 | 200 µl | RUO | ||
Abbexa | CD28 | abx228284 | T-Cell-Specific Surface Glycoprotein CD28 (CD28) Antibody (AF488) | Mouse | Monoclonal | Hamster | T-Cell-Specific Surface Glycoprotein CD28 (CD28) | AF488 | FCM | 125 | 50 tests | P31041 | RUO | |
Abbexa | CD28 | abx228285 | T-Cell-Specific Surface Glycoprotein CD28 (CD28) Antibody (AF647) | Mouse | Monoclonal | Hamster | T-Cell-Specific Surface Glycoprotein CD28 (CD28) | IgG | AF647 | FCM | 125 | 50 tests | P31041 | RUO |
Abbexa | CD28 | abx228279 | T-Cell-Specific Surface Glycoprotein CD28 (CD28) Antibody (APC) | Mouse | Monoclonal | Hamster | T-Cell-Specific Surface Glycoprotein CD28 (CD28) | IgG | APC | FCM | 100 | 50 tests | P31041 | RUO |
Abbexa | CD28 | abx228276 | T-Cell-Specific Surface Glycoprotein CD28 (CD28) Antibody (Biotin) | Mouse | Monoclonal | Hamster | T-Cell-Specific Surface Glycoprotein CD28 (CD28) | IgG | Biotin | FCM | 143.75 | 50 µg | P31041 | RUO |
Abbexa | CD28 | abx228280 | T-Cell-Specific Surface Glycoprotein CD28 (CD28) Antibody (PE / Cyanine 5) | Mouse | Monoclonal | Hamster | T-Cell-Specific Surface Glycoprotein CD28 (CD28) | IgG | PE / Cyanine 5 | FCM | 68.75 | 20 tests | P31041 | RUO |
Abbexa | CD28 | abx228281 | T-Cell-Specific Surface Glycoprotein CD28 (CD28) Antibody (PE / Cyanine 7) | Mouse | Monoclonal | Hamster | T-Cell-Specific Surface Glycoprotein CD28 (CD28) | IgG | PE / Cyanine 7 | FCM | 68.75 | 20 tests | P31041 | RUO |
Abbexa | CD28 | abx228278 | T-Cell-Specific Surface Glycoprotein CD28 (CD28) Antibody (PE) | Mouse | Monoclonal | Hamster | T-Cell-Specific Surface Glycoprotein CD28 (CD28) | IgG | PE | FCM | 87.5 | 50 tests | P31041 | RUO |
Abbexa | CD28 | abx414248 | T-Cell-Specific Surface Glycoprotein CD28 (CD28) Antibody (PE) | Mouse | Monoclonal | Mouse | T-Cell-Specific Surface Glycoprotein CD28 (CD28) | PE | FCM | 487.5 | 100 tests | P31041 | RUO | |
Abbexa | CD28 | abx228283 | T-Cell-Specific Surface Glycoprotein CD28 (CD28) Antibody (PerCP / Cyanine 5.5) | Mouse | Monoclonal | Hamster | T-Cell-Specific Surface Glycoprotein CD28 (CD28) | IgG | PerCP / Cyanine 5.5 | FCM | 68.75 | 20 tests | P31041 | RUO |
Abbexa | CD28 | abx270721 | T-Cell-Specific Surface Glycoprotein CD28 (CD28) Antibody (APC) | Mouse | Polyclonal | Rabbit | T-Cell-Specific Surface Glycoprotein CD28 (CD28) | APC | FCM | 800 | 200 tests | RUO | ||
Abbexa | CD28 | abx137134 | T-Cell-Specific Surface Glycoprotein CD28 (CD28) Antibody (Biotin) | Mouse | Monoclonal | Hamster | T-Cell-Specific Surface Glycoprotein CD28 (CD28) | Biotin | 487.5 | 0.5 mg | RUO | |||
Abbexa | CD28 | abx270489 | T-Cell-Specific Surface Glycoprotein CD28 (CD28) Antibody (FITC) | Mouse | Polyclonal | Rabbit | T-Cell-Specific Surface Glycoprotein CD28 (CD28) | FITC | FCM | 575 | 200 tests | RUO | ||
Abbexa | CD28 | abx270191 | T-Cell-Specific Surface Glycoprotein CD28 (CD28) Antibody | Mouse | Polyclonal | Rabbit | T-Cell-Specific Surface Glycoprotein CD28 (CD28) | Unconjugated | FCM | 300 | 50 tests | RUO | ||
Abbexa | CD28 | abx140106 | T-Cell-Specific Surface Glycoprotein CD28 (CD28) Antibody | Rat | Monoclonal | Mouse | T-Cell-Specific Surface Glycoprotein CD28 (CD28) | Unconjugated | FCM, IP | 237.5 | 0.1 mg | P31042 | RUO | |
Abbexa | CD28 | abx140107 | T-Cell-Specific Surface Glycoprotein CD28 (CD28) Antibody (FITC) | Rat | Monoclonal | Mouse | T-Cell-Specific Surface Glycoprotein CD28 (CD28) | FITC | FCM | 325 | 0.1 mg | P31042 | RUO | |
Abbexa | CD28 | abx140108 | T-Cell-Specific Surface Glycoprotein CD28 (CD28) Antibody (PE) | Rat | Monoclonal | Mouse | T-Cell-Specific Surface Glycoprotein CD28 (CD28) | PE | FCM | 350 | 0.1 mg | P31042 | RUO |
provider | Code | reference | name | origin | expression | host | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | CD28 | abx680116 | Human T-Cell-Specific Surface Glycoprotein CD28 (CD28) Protein | Human | Recombinant | Insect | Unconjugated | SDS-PAGE | 225 | 2 µg | RUO | |
Abbexa | CD28 | abx691860 | Mouse T-Cell-Specific Surface Glycoprotein CD28 (CD28) Protein | Mouse | Recombinant | HEK293 cells | SDS-PAGE | 775 | 100 µg | RUO | ||
Abbexa | CD28 | abx691104 | Human T-Cell-Specific Surface Glycoprotein CD28 (CD28) Protein | Human | Recombinant | Human | SDS-PAGE | 137.5 | 10 µg | P10747 | RUO | |
Abbexa | CD28 | abx168377 | Mouse T-Cell-Specific Surface Glycoprotein CD28 (CD28) Protein | Mouse | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 225 | 10 µg | P31041 | RUO |
Abbexa | CD28 | abx692703 | Mouse T-Cell-Specific Surface Glycoprotein CD28 (CD28) Protein | Mouse | Recombinant | HEK293 cells | SDS-PAGE | 475 | 100 µg | RUO | ||
Abbexa | CD28 | abx691105 | Human T-Cell-Specific Surface Glycoprotein CD28 (CD28) Protein | Human | Recombinant | HEK293 cells | SDS-PAGE | 412.5 | 100 µg | P10747-1 | RUO |
Te recomendamos que si no encuentras lo que buscas, utilices el buscador, refinando la búsqueda según tu criterio y usando Alias, o bien contacta con nosotros.