Human T-Cell-Specific Surface Glycoprotein CD28 (CD28) Protein
234€ (10 µg)
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Name
Human T-Cell-Specific Surface Glycoprotein CD28 (CD28) Protein
Category
Proteins and Peptides
Provider
Abbexa
Reference
abx691104
Tested Applications
SDS-PAGE
Description
T-Cell-Specific Surface Glycoprotein CD28 (CD28) protein is a recombinant Human protein expressed in HEK293 cells.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Proteins and Peptides |
| Immunogen Target | T-Cell-Specific Surface Glycoprotein CD28 (CD28) |
| Host | HEK293 cells |
| Assay Type | Activity: Not tested Sequence Fragment: Asn19-Pro152 Tag: C-terminal Fc tag |
| Origin | Human |
| Observed MW | Calculated MW: 42.3 kDa Observed MW (SDS-PAGE): 60-80 kDa |
| Expression | Recombinant |
| Purity | > 95% (SDS-PAGE) |
| Purification | 0.2 µm filtered prior to lyophilization. |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Form | Lyophilized |
| Tested Applications | SDS-PAGE |
| Buffer | Prior to lyophilization: 20 mM Tris-HCl, 150 mM NaCl, pH 8.0, containing 5%-8% Trehalose, Mannitol and 0.01% Tween 80. |
| Availability | Shipped within 5-15 working days. |
| Storage | Storage: Store lyophilized between -20 °C and -80°C. Stability: Stable when stored reconstituted at 2-8°C for up to 1 week. Reconstituted aliquots are stable at -20°C for up to 3 months. Shelf Life: 12 months. |
| Dry Ice | No |
| UniProt ID | P10747 |
| Gene ID | 940 |
| OMIM | 186760, 620901 |
| Alias | Tp44,T-cell-specific surface glycoprotein CD28 |
| Background | Protein CD28 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. Reconstitute in sterile H2O to prepare a stock solution of concentration 0.25 mg/ml. Do not vortex. Endotoxin Level: < 1.0 EU per µg (LAL method). |
Background
CD28 is a pivotal co-stimulatory molecule expressed on the surface of T cells. It plays a crucial role in the activation and survival of T cells, which are essential components of the adaptive immune system. CD28 is predominantly found on CD4+ T helper cells, although it is also present on a subset of CD8+ cytotoxic T cells. The interaction of CD28 with its ligands, CD80 (B7-1) and CD86 (B7-2), on antigen-presenting cells (APCs) provides the necessary secondary signals that, together with signals from the T cell receptor (TCR), lead to full T cell activation, proliferation, and differentiation. The presence and function of CD28 are vital for initiating effective immune responses and for maintaining T cell homeostasis and tolerance.
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