T-Cell-Specific Surface Glycoprotein CD28 Phospho-Tyr218 (CD28 pY218) Antibody
221€ (50 µg)
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935106861
info@markelab.com
name
T-Cell-Specific Surface Glycoprotein CD28 Phospho-Tyr218 (CD28 pY218) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx325546
tested applications
ELISA, WB
Description
CD28 (pY218) Antibody is a Rabbit Polyclonal against CD28 (pY218).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | T-Cell-Specific Surface Glycoprotein CD28 Phospho-Tyr218 (CD28 pY218) |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Assay Data | Modification: Phosphorylation // Target Modification: Tyr218 |
| Recommended Dilution | ELISA: 1/40000, WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by affinity chromatography. |
| Size 1 | 50 µg |
| Size 2 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P10747 |
| Gene ID | 940 |
| Alias | Tp44,T-cell-specific surface glycoprotein CD28 |
| Background | Antibody anti-CD28 |
| Status | RUO |
Descripción
CD28 is a pivotal co-stimulatory molecule expressed on the surface of T cells. It plays a crucial role in the activation and survival of T cells, which are essential components of the adaptive immune system. CD28 is predominantly found on CD4+ T helper cells, although it is also present on a subset of CD8+ cytotoxic T cells. The interaction of CD28 with its ligands, CD80 (B7-1) and CD86 (B7-2), on antigen-presenting cells (APCs) provides the necessary secondary signals that, together with signals from the T cell receptor (TCR), lead to full T cell activation, proliferation, and differentiation. The presence and function of CD28 are vital for initiating effective immune responses and for maintaining T cell homeostasis and tolerance.
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