T-Cell-Specific Surface Glycoprotein CD28 (CD28) Antibody
299€ (0.1 mg)
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Name
T-Cell-Specific Surface Glycoprotein CD28 (CD28) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx139215
Tested Applications
WB, IHC, IF/ICC, FCM, IP, FUNC
Description
CD28 Antibody is a Mouse Monoclonal against CD28.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: T-Cell-Specific Surface Glycoprotein CD28 (CD28) Immunogen: DC28.1.3.3 murine T cell hybridoma transfected with Human CD28 cDNA. |
| Host | Mouse |
| Reactivity | Human, Monkey |
| Assay Type | Concentration: 1 mg/ml |
| Recommended Dilution | Validated in IHC-F and ICC. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Isotype | IgG1 Kappa |
| Clone ID | K486 |
| Purity | > 95% (SDS-PAGE) |
| Purification | Purified by Protein A affinity chromatography. |
| Size 1 | 0.1 mg |
| Tested Applications | WB, IHC, IF/ICC, FCM, IP, FUNC |
| Buffer | LE/AF PBS solution, 0.2 µm filter sterilized. |
| Availability | Shipped within 5-12 working days. |
| Storage | Store at 2-8°C. Do not freeze. |
| Dry Ice | No |
| UniProt ID | P10747 |
| Gene ID | 940 |
| Alias | Tp44,T-cell-specific surface glycoprotein CD28 |
| Background | Antibody anti-CD28 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
CD28 is a pivotal co-stimulatory molecule expressed on the surface of T cells. It plays a crucial role in the activation and survival of T cells, which are essential components of the adaptive immune system. CD28 is predominantly found on CD4+ T helper cells, although it is also present on a subset of CD8+ cytotoxic T cells. The interaction of CD28 with its ligands, CD80 (B7-1) and CD86 (B7-2), on antigen-presenting cells (APCs) provides the necessary secondary signals that, together with signals from the T cell receptor (TCR), lead to full T cell activation, proliferation, and differentiation. The presence and function of CD28 are vital for initiating effective immune responses and for maintaining T cell homeostasis and tolerance.
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