Human T-Cell-Specific Surface Glycoprotein CD28 (CD28) Protein
429€ (100 µg)
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935106861
info@markelab.com
name
Human T-Cell-Specific Surface Glycoprotein CD28 (CD28) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx691105
tested applications
SDS-PAGE
Description
Human CD28 Protein is a recombinant protein from Human produced in HEK293 Cells. A DNA sequence encoding the human CD28 isoform 1 (P10747-1) extracellular domain (Met 1-Pro 152) was was fused with the Fc region of human IgG1 at the C-terminus.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | CD28 |
| Host | HEK293 cells |
| Origin | Human |
| Observed MW | Molecular Weight: 42 kDa Sequence Fragment: Met1-Pro152 Tag: C-terminal Fc tag Validity: The validity for this protein is 12 months. |
| Expression | Recombinant |
| Purity | > 90% (SDS-PAGE) |
| Size 1 | 100 µg |
| Size 2 | 200 µg |
| Form | |
| Tested Applications | SDS-PAGE |
| Buffer | Lyophilized from sterile PBS, pH 7.4. |
| Availability | Shipped within 5-15 working days. |
| Storage | Aliquot and store at -20°C or -80°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P10747-1 |
| Alias | Tp44,T-cell-specific surface glycoprotein CD28 |
| Background | Protein CD28 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
CD28 is a pivotal co-stimulatory molecule expressed on the surface of T cells. It plays a crucial role in the activation and survival of T cells, which are essential components of the adaptive immune system. CD28 is predominantly found on CD4+ T helper cells, although it is also present on a subset of CD8+ cytotoxic T cells. The interaction of CD28 with its ligands, CD80 (B7-1) and CD86 (B7-2), on antigen-presenting cells (APCs) provides the necessary secondary signals that, together with signals from the T cell receptor (TCR), lead to full T cell activation, proliferation, and differentiation. The presence and function of CD28 are vital for initiating effective immune responses and for maintaining T cell homeostasis and tolerance.
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