Family main features
Atypical chemokine receptors (ACKRs) are a group of receptors that are structurally related to conventional chemokine receptors but have distinct functions in regulating chemokine signaling. ACKRs share structural similarities with conventional chemokine receptors, including seven transmembrane domains characteristic of GPCRs. However, they may lack certain conserved motifs or exhibit variations in their intracellular domains that affect signaling capabilities. Unlike conventional chemokine receptors, which typically signal through G-protein coupled receptor (GPCR) pathways to promote cell migration and activation, ACKRs often act as scavengers or decoy receptors for chemokines, modulating the availability and activity of these signaling molecules without inducing classical chemokine signaling responses. ACKRs are capable of binding to specific chemokines, but they typically do not induce downstream signaling cascades associated with cell activation or migration. Instead, ACKRs often internalize bound chemokines or sequester them on cell surfaces, thereby regulating the availability and distribution of chemokines in tissues. By scavenging or sequestering chemokines, ACKRs can modulate the formation and maintenance of chemokine gradients within tissues. This can influence the directional migration of immune cells and other cell types in physiological and pathological contexts, such as inflammation and immune surveillance. ACKRs are involved in immune regulation and contribute to the modulation of immune responses. They can affect the trafficking and activation of immune cells, as well as the development of immune cell-mediated inflammatory responses. Dysregulation of ACKRs has been implicated in various diseases, including inflammatory disorders, cancer, and infectious diseases. Altered expression or function of ACKRs can disrupt chemokine gradients and immune cell trafficking, contributing to disease pathogenesis.
ACKRs share structural similarities with classical chemokine receptors but have unique features that differentiate them:
The main members of the ACKR family include:
ACKRs play several critical roles in the immune system and homeostasis:
ACKRs interact with various molecules and cellular components:
Dysregulation or mutations in ACKRs can lead to various pathological conditions:
Atypical chemokine receptors (ACKRs) are a unique class of chemokine receptors that primarily function as chemokine scavengers, regulating chemokine levels and gradients to modulate immune responses and maintain homeostasis. Unlike classical chemokine receptors, ACKRs do not signal through traditional GPCR pathways but play crucial roles in inflammation resolution, immune cell positioning, and developmental processes. Dysregulation of ACKRs is associated with various diseases, including inflammatory disorders, cancer, and infectious diseases, highlighting their importance in health and disease. Understanding the structure, function, and clinical implications of ACKRs provides valuable insights into their roles in immune regulation and potential therapeutic targets.
Atypical chemokine receptor 1 (Duffy blood group) (ACKR1)
FY,Dfy,GPD,DARC,GpFy,CCBP1,CD234
Atypical chemokine receptor 2(ACKR2)
CCBP2,CCR10,CCR9,CMKBR9,D6
Atypical chemokine receptor 4(ACKR4)
ACKR4,PPR1,CCBP2,CCR10,CCR11,CCRL1,VSHK1,CCR-11,CKR-11,CCX CKR,CCX-CKR,CC-CKR-11
En la tabla siguiente se muestra una comparativa de todos los reactivos disponibles en nuestro catálogo (Proteins and Peptides, Primary Antibodies, ELISA Kits, CLIA Kits) relacionados con ACKR - Atypical chemokine receptor
Se muestran ordenados por categorías para poder comparar cómodamente sus características principales. Esta tabla, que contiene un enlace con la ficha de cada producto, es exportable a Excel.
Esta página contiene 33 reactivos de las marcas (Abbexa, FineTest) que se corresponden con tu busqueda
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provider | Code | reference | name | reactivity | sample type | assay type | test range | sensitivity | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | ACKR1 | abx151255 | Human Atypical Chemokine Receptor 1 (ACKR1) ELISA Kit | Human | Serum,Plasma,Cell lysates,Other biological fluids | Sandwich | 0.156 ng/ml - 10 ng/ml | < 0.06 ng/ml | 662.5 | 96 tests | Q16570 | RUO |
Abbexa | ACKR1 | abx492984 | Human Atypical Chemokine Receptor 1 (ACKR1) CLIA Kit | Human | Tissue homogenates, cell lysates and other biological fluids. | Sandwich | 1.37 pg/ml - 1000 pg/ml | < 0.49 pg/ml | 812.5 | 96 tests | Q16570 | RUO |
Abbexa | ACKR2 | abx386326 | Human Atypical Chemokine Receptor 2 (ACKR2) ELISA Kit | Human | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 0.313 ng/ml - 20 ng/ml | < 0.115 ng/ml | 687.5 | 96 tests | O00590 | RUO |
Abbexa | ACKR4 | abx354326 | Human Atypical Chemokine Receptor 4 (ACKR4) ELISA Kit | Human | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 1.56 ng/ml - 100 ng/ml | 0.94 ng/ml | 587.5 | 96 tests | Q9NPB9 | RUO |
Abbexa | ACKR1 | abx500743 | Mouse Atypical Chemokine Receptor 1 (ACKR1) ELISA Kit | Mouse | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 0.156 ng/ml - 10 ng/ml | 687.5 | 96 tests | Q9QUI6, Q53ZP8 | RUO | |
Abbexa | ACKR2 | abx500745 | Mouse Atypical chemokine receptor 2 (ACKR2) ELISA Kit | Mouse | Tissue homogenates,Cell lysates,Other biological fluids | 0.156 ng/ml - 10 ng/ml | 687.5 | 96 tests | O08707 | RUO | ||
Abbexa | ACKR4 | abx255250 | Mouse Atypical Chemokine Receptor 4 (ACKR4) ELISA Kit | Mouse | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 0.156 ng/ml - 10 ng/ml | 0.1 ng/ml | 525 | 96 tests | Q924I3 | RUO |
Abbexa | ACKR4 | abx196803 | Mouse Atypical Chemokine Receptor 4 (ACKR4) CLIA Kit | Mouse | Serum, plasma and other biological fluids. | Sandwich | 31.2 pg/ml - 2000 pg/ml | 18.8 pg/ml | 618.75 | 96 tests | RUO | |
Abbexa | ACKR4 | abx256781 | Rat Atypical Chemokine Receptor 4 (ACKR4) ELISA Kit | Rat | Serum,Plasma,Other biological fluids | Sandwich | 78 pg/ml - 5000 pg/ml | 46.9 pg/ml | 562.5 | 96 tests | RUO | |
Abbexa | ACKR4 | abx196804 | Rat Atypical Chemokine Receptor 4 (ACKR4) CLIA Kit | Rat | Serum, plasma and other biological fluids. | Sandwich | 15.6 pg/ml - 1000 pg/ml | 9.38 pg/ml | 618.75 | 96 tests | RUO |
provider | Code | reference | name | reactivity | clonality | host | immunogen target | isotype | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | ACKR1 | abx430507 | Atypical Chemokine Receptor 1 (ACKR1) Antibody | Human | Polyclonal | Goat | Atypical Chemokine Receptor 1 (ACKR1) | Unconjugated | P-ELISA, WB, IHC, FCM | 387.5 | 200 µl | Q16570 | RUO | |
Abbexa | ACKR1 | abx322847 | Atypical Chemokine Receptor 1 (ACKR1) Antibody | Human | Polyclonal | Rabbit | Atypical Chemokine Receptor 1 (ACKR1) | Unconjugated | ELISA, IF/ICC | 187.5 | 50 µg | Q16570 | RUO | |
Abbexa | ACKR1 | abx402225 | Atypical chemokine receptor 1 (ACKR1) Antibody | Human | Monoclonal | Rabbit | Atypical chemokine receptor 1 (ACKR1) | Unconjugated | ELISA, FCM | 287.5 | 50 µl | Q16570 | RUO | |
Abbexa | ACKR1 | abx412034 | Atypical Chemokine Receptor 1 (ACKR1) Antibody | Human | Polyclonal | Rabbit | Atypical Chemokine Receptor 1 (ACKR1) | Unconjugated | WB, IHC | 462.5 | 100 µg | Q16570 | RUO | |
Abbexa | ACKR1 | abx015232 | Atypical Chemokine Receptor 1 (ACKR1) Antibody | Human | Polyclonal | Rabbit | Atypical Chemokine Receptor 1 (ACKR1) | Unconjugated | ELISA, IF/ICC | 43.75 | 10 µg | Q16570 | RUO | |
Abbexa | ACKR1 | abx412035 | Atypical Chemokine Receptor 1 (ACKR1) Antibody | Human | Polyclonal | Rabbit | Atypical Chemokine Receptor 1 (ACKR1) | Unconjugated | WB, IHC | 475 | 100 µg | Q16570 | RUO | |
Abbexa | ACKR1 | abx430508 | Atypical Chemokine Receptor 1 (ACKR1) Antibody (Biotin) | Human | Polyclonal | Goat | Atypical Chemokine Receptor 1 (ACKR1) | Biotin | P-ELISA, WB, IHC, FCM | 387.5 | 200 µl | Q16570 | RUO | |
Abbexa | ACKR1 | abx318569 | Atypical Chemokine Receptor 1 (ACKR1) Antibody | Human | Polyclonal | Rabbit | Atypical Chemokine Receptor 1 (ACKR1) | Unconjugated | ELISA, WB, IF/ICC | 162.5 | 20 µg | Q16570 | RUO | |
Abbexa | ACKR1 | abx112186 | Atypical Chemokine Receptor 1 (ACKR1) Antibody | Human | Polyclonal | Rabbit | Atypical Chemokine Receptor 1 (ACKR1) | Unconjugated | ELISA, WB | 612.5 | 100 µl | Q16570 | RUO | |
Abbexa | ACKR1 | abx232243 | Atypical Chemokine Receptor 1 (ACKR1) Antibody | Human | Polyclonal | Rabbit | Atypical Chemokine Receptor 1 (ACKR1) | Unconjugated | ELISA, WB, IHC | 350 | 100 µg | Q16570 | RUO | |
Abbexa | ACKR2 | abx322815 | Atypical Chemokine Receptor 2 (ACKR2) Antibody | Human | Polyclonal | Rabbit | Atypical Chemokine Receptor 2 (ACKR2) | Unconjugated | ELISA, IF/ICC | 187.5 | 50 µg | O00590 | RUO | |
Abbexa | ACKR2 | abx015224 | Atypical Chemokine Receptor 2 (ACKR2) Antibody | Human | Polyclonal | Rabbit | Atypical Chemokine Receptor 2 (ACKR2) | Unconjugated | ELISA, WB, IF/ICC | 43.75 | 10 µg | O00590 | RUO | |
Abbexa | ACKR2 | abx324784 | Atypical Chemokine Receptor 2 (ACKR2) Antibody | Human | Polyclonal | Rabbit | Atypical Chemokine Receptor 2 (ACKR2) | Unconjugated | ELISA, WB, IHC, IF/ICC | 187.5 | 50 µg | O00590 | RUO | |
Abbexa | ACKR2 | abx119630 | Atypical Chemokine Receptor 2 (ACKR2) Antibody | Human | Polyclonal | Rabbit | Atypical Chemokine Receptor 2 (ACKR2) | Unconjugated | IF/ICC | 43.75 | 10 µg | O00590 | RUO | |
Abbexa | ACKR2 | abx231341 | Atypical Chemokine Receptor 2 (ACKR2) Antibody | Human | Polyclonal | Rabbit | Atypical Chemokine Receptor 2 (ACKR2) | Unconjugated | ELISA, IHC | 350 | 100 µg | O00590 | RUO | |
Abbexa | ACKR4 | abx249439 | Atypical Chemokine Receptor 4 (ACKR4) Antibody | Human | Polyclonal | Rabbit | Atypical Chemokine Receptor 4 (ACKR4) | Unconjugated | ELISA, WB, IF/ICC | 43.75 | 10 µg | Q9NPB9 | RUO | |
Abbexa | ACKR4 | abx015221 | Atypical Chemokine Receptor 4 (ACKR4) Antibody | Human | Polyclonal | Rabbit | Atypical Chemokine Receptor 4 (ACKR4) | Unconjugated | ELISA, WB, IF/ICC | 43.75 | 10 µg | Q9NPB9 | RUO | |
Abbexa | ACKR4 | abx325708 | Atypical Chemokine Receptor 4 (ACKR4) Antibody | Human | Polyclonal | Rabbit | Atypical Chemokine Receptor 4 (ACKR4) | Unconjugated | ELISA, WB, IF/ICC | 187.5 | 50 µg | Q9NPB9 | RUO | |
Abbexa | ACKR4 | abx325726 | Atypical Chemokine Receptor 4 (ACKR4) Antibody | Human | Polyclonal | Rabbit | Atypical Chemokine Receptor 4 (ACKR4) | Unconjugated | ELISA, WB, IF/ICC | 187.5 | 50 µg | Q9NPB9 | RUO | |
Abbexa | ACKR1 | abx103809 | Atypical Chemokine Receptor 1 (ACKR1) Antibody | Mouse | Polyclonal | Rabbit | Atypical Chemokine Receptor 1 (ACKR1) | Unconjugated | WB, IHC, IF/ICC | 262.5 | 100 µl | Q9QUI6, Q53ZP8 | RUO |
provider | Code | reference | name | origin | expression | host | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | ACKR1 | abx652168 | Human Atypical Chemokine Receptor 1 (ACKR1) Protein | Human | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 2112.5 | 1 mg | Q16570 | RUO |
Abbexa | ACKR1 | abx066365 | Mouse Atypical Chemokine Receptor 1 (ACKR1) Protein | Mouse | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 225 | 10 µg | Q9QUI6, Q53ZP8 | RUO |
FineTest | ACKR2 | P2105 | Recombinant Human ACKR2 | Human | Recombinant | E.Coli | Western Blot, ELISA | 50μg | O00590 | RUO |
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