Human Atypical Chemokine Receptor 2 (ACKR2) ELISA Kit

Este producto es parte de ACKR - Atypical chemokine receptor
Human Atypical Chemokine Receptor 2 (ACKR2) ELISA Kit

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935106861

info@markelab.com

Precio

687.5€ (96 tests)

Elisa Kits ACKR2

proveedor

Abbexa

reference

abx386326

Tested Applications

ELISA

reactivity

Human

status

RUO

clonality

Descripción

Human Atypical Chemokine Receptor 2 (ACKR2) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human Chemokine Binding Protein 2 (CCBP2) concentrations in tissue homogenates, cell lysates and other biological fluids.


Background

ACKR2 is a non-classical chemokine receptor that functions as a decoy and scavenger receptor, specifically binding pro-inflammatory CC chemokines to modulate immune responses and resolve inflammation. Unlike signaling chemokine receptors, ACKR2 does not trigger intracellular signaling but instead internalizes and degrades its ligands, reducing chemokine availability and dampening inflammation. It is primarily expressed on lymphatic endothelial cells and plays a critical role in maintaining immune homeostasis by clearing chemokines from tissues and promoting the resolution of inflammation. ACKR2 is also involved in shaping chemokine gradients, ensuring proper immune cell trafficking and preventing chronic inflammatory conditions. Dysregulation of ACKR2 has been linked to autoimmune diseases, chronic inflammation, and cancer, where its altered expression may contribute to pathological immune cell infiltration and tumor progression. Its scavenging activity and role in regulating immune responses make ACKR2 a potential therapeutic target for inflammatory and immune-related diseases.

Características del producto

category

ELISA Kits


immunogen target

Atypical Chemokine Receptor 2 (ACKR2)


reactivity

Human


test range

0.313 ng/ml - 20 ng/ml


sensitivity

< 0.115 ng/ml


assay type

Sandwich


assay data

Quantitative


detection method

Colorimetric


sample type

Tissue homogenates,Cell lysates,Other biological fluids


size 1

96 tests


size 2

5 × 96 tests


size 3

10 × 96 tests


alias

CCBP2,CCR10,CCR9,CMKBR9,D6


storage

Enviado a 4 °C. Una vez recibido, almacene el kit de acuerdo con las instrucciones citadas en el manual del kit


or code

ACKR2


dry ice

No


note

This product is for research use only. <p></p> The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. <p></p> Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.


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