Atypical Chemokine Receptor 4 (ACKR4) Antibody

Este producto es parte de ACKR - Atypical chemokine receptor
Product Graph
221€ (50 µg)

Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.

935106861
info@markelab.com
name
Atypical Chemokine Receptor 4 (ACKR4) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx325708
tested applications
ELISA, WB, IF/ICC

Description

ACKR4 Antibody is a Rabbit Polyclonal against ACKR4.

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Primary Antibodies
Immunogen Target
Atypical Chemokine Receptor 4 (ACKR4)
Host
Rabbit
Reactivity
Human, Mouse
Recommended Dilution
ELISA: 1/40000, WB: 1/500 - 1/2000, IF/ICC: 1/200 - 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Clonality
Polyclonal
Conjugation
Unconjugated
Isotype
IgG
Purification
Purified by affinity chromatography.
Size 1
50 µg
Size 2
100 µg
Form
Liquid
Tested Applications
ELISA, WB, IF/ICC
Buffer
PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Availability
Shipped within 5-10 working days.
Storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Dry Ice
No
UniProt ID
Q9NPB9
Gene ID
51554
Alias
ACKR4,PPR1,CCBP2,CCR10,CCR11,CCRL1,VSHK1,CCR-11,CKR-11,CCX CKR,CCX-CKR,CC-CKR-11
Background
Antibody anti-ACKR4
Status
RUO

Descripción

ACKR4 is a non-signaling chemokine receptor that acts as a scavenger receptor for homeostatic chemokines, including CCL19, CCL21, and CXCL13, which are critical for lymphoid tissue organization and immune cell trafficking. By internalizing and degrading its ligands, ACKR4 modulates chemokine gradients and prevents excessive immune cell recruitment, contributing to immune homeostasis. It is predominantly expressed in lymphatic endothelial cells, thymic epithelial cells, and certain stromal cells, where it regulates the migration and positioning of T cells, dendritic cells, and other immune cells. ACKR4 plays a key role in T-cell development, particularly in guiding thymocytes during positive and negative selection in the thymus. Dysregulation of ACKR4 has been implicated in autoimmune diseases, inflammatory conditions, and tumor metastasis, where altered chemokine gradients can lead to immune cell mislocalization and dysregulated immune responses. Its regulatory role in chemokine biology underscores ACKR4’s importance in maintaining immune balance and preventing pathological inflammation.
Related Products
abx015221
Atypical Chemokine Receptor 4 (ACKR4) Antibody
Rabbit polyclonal antibody against CCRL1 protein. Immunogen region is N-terminal.
Ver Producto
abx196803
Mouse Atypical Chemokine Receptor 4 (ACKR4) CLIA Kit
Mouse Chemokine C-C-Motif Receptor Like Protein 1 (CCRL1) Chemiluminescent Immunoassay (CLIA) Kit is a Chemiluminescent Immunoassay (CLIA) kit against Chemokine C-C-Motif Receptor Like Protein 1 (CCRL1).
Ver Producto
abx196804
Rat Atypical Chemokine Receptor 4 (ACKR4) CLIA Kit
Rat Chemokine C-C-Motif Receptor Like Protein 1 (CCRL1) Chemiluminescent Immunoassay (CLIA) Kit is a Chemiluminescent Immunoassay (CLIA) kit against Chemokine C-C-Motif Receptor Like Protein 1 (CCRL1).
Ver Producto