Mouse Atypical Chemokine Receptor 4 (ACKR4) CLIA Kit
643.5€ (96 tests)
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935106861
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name
Mouse Atypical Chemokine Receptor 4 (ACKR4) CLIA Kit
category
CLIA Kits
provider
Abbexa
reference
abx196803
tested applications
CLIA
Description
Mouse Chemokine C-C-Motif Receptor Like Protein 1 (CCRL1) Chemiluminescent Immunoassay (CLIA) Kit is a Chemiluminescent Immunoassay (CLIA) kit against Chemokine C-C-Motif Receptor Like Protein 1 (CCRL1).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | CLIA Kits |
| Immunogen Target | Atypical Chemokine Receptor 4 (ACKR4) |
| Reactivity | Mouse |
| Detection Method | Chemiluminescent |
| Assay Data | Quantitative |
| Assay Type | Sandwich |
| Test Range | 31.2 pg/ml - 2000 pg/ml |
| Sensitivity | 18.8 pg/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Form | Lyophilized |
| Tested Applications | CLIA |
| Sample Type | Serum, plasma and other biological fluids. |
| Availability | Shipped within 5-12 working days. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| Alias | ACKR4,PPR1,CCBP2,CCR10,CCR11,CCRL1,VSHK1,CCR-11,CKR-11,CCX CKR,CCX-CKR,CC-CKR-11 |
| Background | CLIA Kits ACKR4 |
| Status | RUO |
| Note | The validity for this kit is 6 months. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
ACKR4 is a non-signaling chemokine receptor that acts as a scavenger receptor for homeostatic chemokines, including CCL19, CCL21, and CXCL13, which are critical for lymphoid tissue organization and immune cell trafficking. By internalizing and degrading its ligands, ACKR4 modulates chemokine gradients and prevents excessive immune cell recruitment, contributing to immune homeostasis. It is predominantly expressed in lymphatic endothelial cells, thymic epithelial cells, and certain stromal cells, where it regulates the migration and positioning of T cells, dendritic cells, and other immune cells. ACKR4 plays a key role in T-cell development, particularly in guiding thymocytes during positive and negative selection in the thymus. Dysregulation of ACKR4 has been implicated in autoimmune diseases, inflammatory conditions, and tumor metastasis, where altered chemokine gradients can lead to immune cell mislocalization and dysregulated immune responses. Its regulatory role in chemokine biology underscores ACKR4’s importance in maintaining immune balance and preventing pathological inflammation.
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