Human Atypical Chemokine Receptor 4 (ACKR4) ELISA Kit
611€ (96 tests)
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name
Human Atypical Chemokine Receptor 4 (ACKR4) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx354326
tested applications
ELISA
Description
Human Atypical Chemokine Receptor 4 (ACKR4) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human Atypical Chemokine Receptor 4 (ACKR4) concentrations in tissue homogenates, cell lysates and other biological fluids.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | ELISA Kits |
| Immunogen Target | Atypical Chemokine Receptor 4 (ACKR4) |
| Reactivity | Human |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Assay Type | Sandwich |
| Test Range | 1.56 ng/ml - 100 ng/ml |
| Sensitivity | 0.94 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Size 2 | 5 × 96 tests |
| Size 3 | 10 × 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-7 working days. The validity for this kit is at least 6 months. Up to 12 months validity can be provided on request. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | Q9NPB9 |
| Alias | ACKR4,PPR1,CCBP2,CCR10,CCR11,CCRL1,VSHK1,CCR-11,CKR-11,CCX CKR,CCX-CKR,CC-CKR-11 |
| Background | Elisa kits for ACKR4 |
| Status | RUO |
| Note | Validity: The validity for this kit is at least 6 months. Up to 12 months validity can be provided on request. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
ACKR4 is a non-signaling chemokine receptor that acts as a scavenger receptor for homeostatic chemokines, including CCL19, CCL21, and CXCL13, which are critical for lymphoid tissue organization and immune cell trafficking. By internalizing and degrading its ligands, ACKR4 modulates chemokine gradients and prevents excessive immune cell recruitment, contributing to immune homeostasis. It is predominantly expressed in lymphatic endothelial cells, thymic epithelial cells, and certain stromal cells, where it regulates the migration and positioning of T cells, dendritic cells, and other immune cells. ACKR4 plays a key role in T-cell development, particularly in guiding thymocytes during positive and negative selection in the thymus. Dysregulation of ACKR4 has been implicated in autoimmune diseases, inflammatory conditions, and tumor metastasis, where altered chemokine gradients can lead to immune cell mislocalization and dysregulated immune responses. Its regulatory role in chemokine biology underscores ACKR4’s importance in maintaining immune balance and preventing pathological inflammation.
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