Human Atypical Chemokine Receptor 1 (ACKR1) Protein
2197€ (1 mg)
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935106861
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name
Human Atypical Chemokine Receptor 1 (ACKR1) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx652168
tested applications
WB, SDS-PAGE
Description
Atypical Chemokine Receptor 1 (ACKR1) Protein is a Recombinant protein from Human.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Atypical Chemokine Receptor 1 (ACKR1) |
| Host | E. coli |
| Origin | Human |
| Conjugation | Unconjugated |
| Observed MW | Molecular Weight: Calculated MW: 18.3 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Val176-Leu332 Tag: N-terminal His tag |
| Expression | Recombinant |
| Purity | > 95% |
| Size 1 | 1 mg |
| Size 2 | 5 mg |
| Form | Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 1-2 months. |
| Storage | Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q16570 |
| Gene ID | 2532 |
| OMIM | 110700 |
| Alias | FY,Dfy,GPD,DARC,GpFy,CCBP1,CD234 |
| Background | Protein ACKR1 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
ACKR1, also known as the Duffy antigen receptor for chemokines (DARC), is a non-signaling chemokine receptor that binds a broad range of chemokines, acting as a scavenger to regulate inflammation and immune responses. Unlike classical chemokine receptors, ACKR1 lacks the ability to couple to G proteins and initiate intracellular signaling. It is expressed on endothelial cells, erythrocytes, and epithelial cells, where it functions to modulate chemokine levels and gradients by sequestering excess chemokines, thereby preventing excessive immune cell recruitment and inflammation. ACKR1 also plays a critical role in malaria, as it serves as a receptor for Plasmodium vivax and Plasmodium knowlesi, enabling the parasite to invade red blood cells. Variations in the ACKR1 gene, particularly the Duffy-null polymorphism, confer resistance to these malaria species and are highly prevalent in certain populations. Beyond its role in malaria, dysregulation of ACKR1 expression has been implicated in inflammatory diseases and cancer metastasis, highlighting its importance in immune regulation and disease pathology.
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