Atypical Chemokine Receptor 2 (ACKR2) Antibody
52€ (10 µg)
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935106861
info@markelab.com
name
Atypical Chemokine Receptor 2 (ACKR2) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx015224
tested applications
WB, IF/ICC
Description
Rabbit polyclonal antibody against CCBP2 protein. Immunogen region is C-terminal.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Atypical Chemokine Receptor 2 (ACKR2) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified from rabbit antiserum by affinity chromatography using epitope-specific immunogen. |
| Size 1 | 10 µg |
| Size 2 | 100 µg |
| Size 3 | 200 µg |
| Size 4 | 300 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Tested Applications | WB, IF/ICC |
| Buffer | PBS (without Mg<sup>2+</sup> and Ca<sup>2+</sup>), pH 7.4, 150 mM NaCl, 0.02% sodium azide, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | O00590 |
| Alias | CCBP2,CCR10,CCR9,CMKBR9,D6 |
| Background | Antibody anti-ACKR2 |
| Status | RUO |
| Note | Concentration: 1 mg/ml - |
Descripción
ACKR2 is a non-classical chemokine receptor that functions as a decoy and scavenger receptor, specifically binding pro-inflammatory CC chemokines to modulate immune responses and resolve inflammation. Unlike signaling chemokine receptors, ACKR2 does not trigger intracellular signaling but instead internalizes and degrades its ligands, reducing chemokine availability and dampening inflammation. It is primarily expressed on lymphatic endothelial cells and plays a critical role in maintaining immune homeostasis by clearing chemokines from tissues and promoting the resolution of inflammation. ACKR2 is also involved in shaping chemokine gradients, ensuring proper immune cell trafficking and preventing chronic inflammatory conditions. Dysregulation of ACKR2 has been linked to autoimmune diseases, chronic inflammation, and cancer, where its altered expression may contribute to pathological immune cell infiltration and tumor progression. Its scavenging activity and role in regulating immune responses make ACKR2 a potential therapeutic target for inflammatory and immune-related diseases.
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