Atypical Chemokine Receptor 1 (ACKR1) Antibody
364€ (100 µg)
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935106861
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name
Atypical Chemokine Receptor 1 (ACKR1) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx232243
tested applications
ELISA, WB, IHC
Description
ACKR1 Antibody is a Rabbit Polyclonal against ACKR1.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Atypical Chemokine Receptor 1 (ACKR1) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1/500 - 1/2000, IHC: 1/20 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purity | ≥ 95% (SDS-PAGE) |
| Purification | Purified by immunogen affinity chromatography. |
| Size 1 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC |
| Buffer | PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol. |
| Availability | Shipped within 5-12 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q16570 |
| Gene ID | 2532 |
| OMIM | 110700 |
| Alias | FY,Dfy,GPD,DARC,GpFy,CCBP1,CD234 |
| Background | Antibody anti-ACKR1 |
| Status | RUO |
| Note | Concentration: 2 mg/ml - Validity: 12 months. |
Descripción
ACKR1, also known as the Duffy antigen receptor for chemokines (DARC), is a non-signaling chemokine receptor that binds a broad range of chemokines, acting as a scavenger to regulate inflammation and immune responses. Unlike classical chemokine receptors, ACKR1 lacks the ability to couple to G proteins and initiate intracellular signaling. It is expressed on endothelial cells, erythrocytes, and epithelial cells, where it functions to modulate chemokine levels and gradients by sequestering excess chemokines, thereby preventing excessive immune cell recruitment and inflammation. ACKR1 also plays a critical role in malaria, as it serves as a receptor for Plasmodium vivax and Plasmodium knowlesi, enabling the parasite to invade red blood cells. Variations in the ACKR1 gene, particularly the Duffy-null polymorphism, confer resistance to these malaria species and are highly prevalent in certain populations. Beyond its role in malaria, dysregulation of ACKR1 expression has been implicated in inflammatory diseases and cancer metastasis, highlighting its importance in immune regulation and disease pathology.
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