Human Atypical Chemokine Receptor 1 (ACKR1) ELISA Kit
Pida mas información
935106861
info@markelab.com
Precio
662.5€ (96 tests)
Elisa Kits ACKR1
proveedor
Abbexareference
abx151255Tested Applications
ELISAreactivity
Humanstatus
RUOclonality
Descripción
Human Duffy Antigen Chemokine Receptor / DARC (ACKR1) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human Duffy Antigen Chemokine Receptor / DARC (ACKR1) concentrations in serum, plasma, cell lysates and other biological fluids. This assay has high sensitivity and excellent specificity for detection of Duffy Blood Group Chemokine Receptor (DARC)No significant cross-reactivity or interference between Duffy Blood Group Chemokine Receptor (DARC) and analogues was observed.
Background
ACKR1, also known as the Duffy antigen receptor for chemokines (DARC), is a non-signaling chemokine receptor that binds a broad range of chemokines, acting as a scavenger to regulate inflammation and immune responses. Unlike classical chemokine receptors, ACKR1 lacks the ability to couple to G proteins and initiate intracellular signaling. It is expressed on endothelial cells, erythrocytes, and epithelial cells, where it functions to modulate chemokine levels and gradients by sequestering excess chemokines, thereby preventing excessive immune cell recruitment and inflammation. ACKR1 also plays a critical role in malaria, as it serves as a receptor for Plasmodium vivax and Plasmodium knowlesi, enabling the parasite to invade red blood cells. Variations in the ACKR1 gene, particularly the Duffy-null polymorphism, confer resistance to these malaria species and are highly prevalent in certain populations. Beyond its role in malaria, dysregulation of ACKR1 expression has been implicated in inflammatory diseases and cancer metastasis, highlighting its importance in immune regulation and disease pathology.
Características del producto
category
ELISA Kits
immunogen target
Atypical Chemokine Receptor 1 (ACKR1)
reactivity
Human
test range
0.156 ng/ml - 10 ng/ml
sensitivity
< 0.06 ng/ml
assay type
Sandwich
assay data
Quantitative
detection method
Colorimetric
sample type
Serum,Plasma,Cell lysates,Other biological fluids
size 1
96 tests
size 2
5 × 96 tests
size 3
10 × 96 tests
alias
FY,Dfy,GPD,DARC,GpFy,CCBP1,CD234
storage
Enviado a 4 °C. Una vez recibido, almacene el kit de acuerdo con las instrucciones citadas en el manual del kit
or code
ACKR1
dry ice
No
uniprot id
note
This product is for research use only. <p></p> The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. <p></p> Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
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