Atypical Chemokine Receptor 1 (ACKR1) Antibody (HRP)

Este producto es parte de ACKR - Atypical chemokine receptor
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169€ (20 µg)

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935106861
info@markelab.com
name
Atypical Chemokine Receptor 1 (ACKR1) Antibody (HRP)
category
Primary Antibodies
provider
Abbexa
reference
abx307132
tested applications
ELISA

Description

ACKR1 Antibody (HRP) is a Rabbit Polyclonal against ACKR1 conjugated to HRP.

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Primary Antibodies
Immunogen Target
Atypical Chemokine Receptor 1 (ACKR1)
Host
Rabbit
Reactivity
Human
Recommended Dilution
Optimal dilutions/concentrations should be determined by the end user.
Clonality
Polyclonal
Conjugation
HRP
Isotype
IgG
Purity
> 95%
Purification
Purified by Protein G.
Size 1
20 µg
Size 2
50 µg
Size 3
100 µg
Size 4
200 µg
Size 5
1 mg
Form
Liquid
Tested Applications
ELISA
Buffer
0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol.
Availability
Shipped within 5-10 working days.
Storage
Aliquot and store at -20°C. Avoid exposure to light. Avoid repeated freeze/thaw cycles.
Dry Ice
No
UniProt ID
Q16570
Gene ID
2532
NCBI Accession
NP_001116423.1, NM_001122951.2, NP_002027.2, NM_002036.3
OMIM
110700
Alias
FY,Dfy,GPD,DARC,GpFy,CCBP1,CD234
Background
Antibody anti-ACKR1
Status
RUO

Descripción

ACKR1, also known as the Duffy antigen receptor for chemokines (DARC), is a non-signaling chemokine receptor that binds a broad range of chemokines, acting as a scavenger to regulate inflammation and immune responses. Unlike classical chemokine receptors, ACKR1 lacks the ability to couple to G proteins and initiate intracellular signaling. It is expressed on endothelial cells, erythrocytes, and epithelial cells, where it functions to modulate chemokine levels and gradients by sequestering excess chemokines, thereby preventing excessive immune cell recruitment and inflammation. ACKR1 also plays a critical role in malaria, as it serves as a receptor for Plasmodium vivax and Plasmodium knowlesi, enabling the parasite to invade red blood cells. Variations in the ACKR1 gene, particularly the Duffy-null polymorphism, confer resistance to these malaria species and are highly prevalent in certain populations. Beyond its role in malaria, dysregulation of ACKR1 expression has been implicated in inflammatory diseases and cancer metastasis, highlighting its importance in immune regulation and disease pathology.

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