ABCF - ATP Binding Cassette Transporter F | Elisa - Clia - Antibody - Protein

Family main features


Background

The ABCF subfamily is part of the ATP-binding cassette (ABC) transporter superfamily, which generally utilizes ATP hydrolysis to transport various molecules across cellular membranes. However, ABCF proteins are unique within the ABC superfamily because they lack transmembrane domains and are not involved in membrane transport. Instead, ABCF proteins play crucial roles in the regulation of translation and protein synthesis.. ABCF1 is a member of the GCN20 subfamily. Unlike other members of the superfamily, this protein lacks the transmembrane domains which are characteristic of most ABC transporters. ABCF1 may be regulated by tumor necrosis factor-alpha and play a role in enhancement of protein synthesis and the inflammation process. ABCF2 acts as a suppressor of the volume-sensitive outwardly rectifying Cl cannel (H+/Cl− exchange transporter 3)


Protein Structure

ABCF proteins are characterized by their structure, which includes:

  • Two Nucleotide Binding Domains (NBDs): These domains bind and hydrolyze ATP, which is crucial for the proteins' functions. Unlike typical ABC transporters, ABCF proteins do not possess transmembrane domains.
  • Lack of Transmembrane Domains: ABCF proteins are cytoplasmic and do not participate in the translocation of substrates across membranes.


Classification and Subtypes

The ABCF subfamily includes several members, each with distinct roles:

  • ABCF1: Involved in translation regulation and protein synthesis, also implicated in inflammatory responses.
  • ABCF2: Functions in translation regulation and may play a role in cellular stress responses.
  • ABCF3: Its exact functions are less well-characterized but likely similar to other ABCF members in translation regulation.


Function and Biological Significance

ABCF proteins are primarily involved in the regulation of translation and protein synthesis:

  1. Translation Regulation: ABCF proteins interact with components of the translation machinery to regulate the initiation, elongation, and termination phases of protein synthesis.
  2. Stress Response: Some ABCF proteins are upregulated in response to cellular stress and may help modulate protein synthesis under such conditions.
  3. Immune Response: ABCF1 has been implicated in the regulation of inflammatory responses, possibly through its interactions with other regulatory proteins involved in immune signaling.


Interactions

ABCF proteins interact with various molecules and proteins:

  1. Translation Machinery: ABCF proteins interact with ribosomal subunits and translation factors to modulate protein synthesis.
  2. Regulatory Proteins: They interact with other cellular proteins that regulate their activity, stability, and localization.
  3. RNA Molecules: ABCF proteins may bind to RNA molecules, influencing their translation and stability.


Clinical Issues

Dysfunction or dysregulation of ABCF proteins can be associated with several clinical conditions:

  1. Inflammatory Diseases: Alterations in ABCF1 function can affect inflammatory responses, potentially contributing to autoimmune and inflammatory diseases.
  2. Cancer: Dysregulation of protein synthesis, in which ABCF proteins play a crucial role, can contribute to the uncontrolled cell growth and proliferation characteristic of cancer.
  3. Stress-Related Disorders: Given their role in stress response, abnormalities in ABCF proteins may be implicated in diseases where cellular stress responses are dysregulated.


Summary

The ABCF subfamily of ATP-binding cassette transporters is unique within the ABC superfamily due to the absence of transmembrane domains and their involvement in translation regulation rather than substrate transport. ABCF proteins play critical roles in protein synthesis, cellular stress responses, and immune regulation. Dysregulation of ABCF proteins can lead to significant clinical conditions, including inflammatory diseases, cancer, and stress-related disorders, highlighting their importance in maintaining cellular homeostasis and proper protein synthesis.



ABCF1 Recommended name:

ATP Binding Cassette Transporter F1(ABCF1)

Aliases for ABCF1

ABC27,ABC50

ABCF2 Recommended name:

ATP Binding Cassette Transporter F2(ABCF2)

Aliases for ABCF2

ABC28,HUSSY-18,HUSSY18

ABCF3 Recommended name:

ATP Binding Cassette Transporter F3(ABCF3)

Aliases for ABCF3

EST201864

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immunoassays

providerCodereferencenamereactivitysample typeassay typetest rangesensitivitypricesize 1uniprot idstatus
AbbexaABCF1abx385547Human ATP Binding Cassette Subfamily F Member 1 (ABCF1) ELISA KitHumanTissue homogenates, cell lysates and other biological fluids.Sandwich0.313 ng/ml - 20 ng/ml< 0.19 ng/ml71596 testsQ8NE71RUO
AbbexaABCF2abx385548Human ATP Binding Cassette Subfamily F Member 2 (ABCF2) ELISA KitHumanTissue homogenates, cell lysates and other biological fluids.Sandwich0.313 ng/ml - 20 ng/ml< 0.19 ng/ml71596 testsQ9UG63RUO
AbbexaABCF3abx500461Human ATP-binding cassette sub-family F member 3 (ABCF3) ELISA KitHumanSerum, plasma, tissue homogenates, cell culture supernatants and other biological fluids.0.156 ng/ml - 10 ng/ml71596 testsQ9NUQ8RUO
AbbexaABCF1abx500455Mouse ATP-binding cassette sub-family F member 1 (ABCF1) ELISA KitMouseTissue homogenates, cell lysates and other biological fluids.0.156 ng/ml - 10 ng/ml71596 testsQ6P542RUO
AbbexaABCF2abx500460Mouse ATP-binding cassette sub-family F member 2 (ABCF2) ELISA KitMouseSerum, plasma, tissue homogenates, cell culture supernatants and other biological fluids.0.156 ng/ml - 10 ng/ml71596 testsQ99LE6RUO
AbbexaABCF3abx500462Mouse ATP-binding cassette sub-family F member 3 (ABCF3) ELISA KitMouseSerum, plasma, tissue homogenates, cell culture supernatants and other biological fluids.0.156 ng/ml - 10 ng/ml71596 testsQ8K268RUO
AbbexaABCF1abx500457Rat ATP Binding Cassette Subfamily F Member 1 (ABCF1) ELISA KitRatTissue homogenates, cell lysates and other biological fluids.0.156 ng/ml - 10 ng/ml71596 testsQ6MG08RUO
AbbexaABCF3abx500463Rat ATP Binding Cassette Subfamily F Member 3 (ABCF3) ELISA KitRatSerum, plasma, tissue homogenates, cell culture supernatants and other biological fluids.0.156 ng/ml - 10 ng/ml71596 testsQ66H39RUO

Primary Antibodies

providerCodereferencenamereactivityclonalityhostimmunogen targetisotypeconjugationtested applicationspricesize 1uniprot idstatus
AbbexaABCF3abx431873ATP Binding Cassette Subfamily F Member 3 (ABCF3) AntibodyPolyclonalGoatATP Binding Cassette Subfamily F Member 3 (ABCF3)UnconjugatedP-ELISA250200 µlRUO
FineTestABCF1FNab00040anti- ABCF1 antibodyhumanpolyclonalRabbitATP-binding cassette, sub-family F(GCN20), member 1IgGUnconjugatedELISA, WB, IP100µgQ8NE71RUO
FineTestABCF2FNab00041anti- ABCF2 antibodyhumanpolyclonalRabbitATP-binding cassette, sub-family F (GCN20), member 2IgGUnconjugatedELISA, WB, IHC100µgQ9UG63RUO
AbbexaABCF1abx038065ATP Binding Cassette Subfamily F Member 1 (ABCF1) AntibodyHumanPolyclonalRabbitATP Binding Cassette Subfamily F Member 1 (ABCF1)UnconjugatedELISA, WB, IHC337.5100 µgRUO
AbbexaABCF1abx130581ATP Binding Cassette Transporter F1 (ABCF1) AntibodyHumanPolyclonalRabbitATP Binding Cassette Transporter F1 (ABCF1)UnconjugatedWB, IHC, IF/ICC275100 µlRUO
AbbexaABCF1abx014233ATP Binding Cassette Subfamily F Member 1 (ABCF1) AntibodyHumanPolyclonalRabbitATP Binding Cassette Subfamily F Member 1 (ABCF1)UnconjugatedELISA, WB43.7510 µgQ8NE71RUO
AbbexaABCF1abx111167ATP Binding Cassette Subfamily F Member 1 (ABCF1) AntibodyHumanPolyclonalRabbitATP Binding Cassette Subfamily F Member 1 (ABCF1)UnconjugatedELISA, WB612.5100 µlQ8NE71RUO
AbbexaABCF1abx327140ATP Binding Cassette Subfamily F Member 1 (ABCF1) AntibodyHumanPolyclonalRabbitATP Binding Cassette Subfamily F Member 1 (ABCF1)UnconjugatedELISA, WB187.550 µgQ8NE71RUO
AbbexaABCF1abx214913ATP Binding Cassette Subfamily F Member 1 (ABCF1) AntibodyHumanPolyclonalRabbitATP Binding Cassette Subfamily F Member 1 (ABCF1)UnconjugatedELISA, IHC25050 µlQ8NE71RUO
AbbexaABCF1abx214914ATP Binding Cassette Subfamily F Member 1 (ABCF1) AntibodyHumanPolyclonalRabbitATP Binding Cassette Subfamily F Member 1 (ABCF1)UnconjugatedELISA, IHC25050 µlQ8NE71RUO
AbbexaABCF1abx230040ATP Binding Cassette Subfamily F Member 1 (ABCF1) AntibodyHumanPolyclonalRabbitATP Binding Cassette Subfamily F Member 1 (ABCF1)UnconjugatedELISA, WB, IP350100 µgQ8NE71RUO
AbbexaABCF2abx321485ATP Binding Cassette Subfamily F Member 2 (ABCF2) AntibodyHumanPolyclonalRabbitATP Binding Cassette Subfamily F Member 2 (ABCF2)UnconjugatedELISA, WB, IHC237.550 µlQ9UG63RUO
AbbexaABCF2abx130582ATP Binding Cassette Subfamily F Member 2 (ABCF2) AntibodyHumanPolyclonalRabbitATP Binding Cassette Subfamily F Member 2 (ABCF2)UnconjugatedWB, IHC, IF/ICC275100 µlRUO
AbbexaABCF2abx029132ATP Binding Cassette Subfamily F Member 2 (ABCF2) AntibodyHumanPolyclonalRabbitATP Binding Cassette Subfamily F Member 2 (ABCF2)UnconjugatedELISA, WB25080 µlQ9UG63RUO
AbbexaABCF2abx212586ATP Binding Cassette Subfamily F Member 2 (ABCF2) AntibodyHumanPolyclonalRabbitATP Binding Cassette Subfamily F Member 2 (ABCF2)UnconjugatedELISA, IHC25050 µlQ9UG63RUO
AbbexaABCF2abx230041ATP Binding Cassette Subfamily F Member 2 (ABCF2) AntibodyHumanPolyclonalRabbitATP Binding Cassette Subfamily F Member 2 (ABCF2)UnconjugatedELISA, WB, IHC350100 µgQ9UG63RUO
AbbexaABCF2abx003252ATP Binding Cassette Subfamily F Member 2 (ABCF2) AntibodyHumanPolyclonalRabbitATP Binding Cassette Subfamily F Member 2 (ABCF2)UnconjugatedWB, IF/ICC17520 µlQ9UG63RUO
AbbexaABCF2abx212451ATP Binding Cassette Subfamily F Member 2 (ABCF2) AntibodyHumanPolyclonalRabbitATP Binding Cassette Subfamily F Member 2 (ABCF2)UnconjugatedELISA, IHC25050 µlQ9UG63RUO
AbbexaABCF2abx111168ATP Binding Cassette Subfamily F Member 2 (ABCF2) AntibodyHumanPolyclonalRabbitATP Binding Cassette Subfamily F Member 2 (ABCF2)UnconjugatedELISA, WB, IHC612.5100 µlQ9UG63RUO
AbbexaABCF2abx014234ATP Binding Cassette Subfamily F Member 2 (ABCF2) AntibodyHumanPolyclonalRabbitATP Binding Cassette Subfamily F Member 2 (ABCF2)UnconjugatedELISA, WB43.7510 µgQ9UG63RUO
AbbexaABCF2abx327982ATP Binding Cassette Subfamily F Member 2 (ABCF2) AntibodyHumanPolyclonalRabbitATP Binding Cassette Subfamily F Member 2 (ABCF2)UnconjugatedELISA, WB187.550 µgQ9UG63RUO
AbbexaABCF3abx301739ATP Binding Cassette Subfamily F Member 3 (ABCF3) AntibodyHumanPolyclonalRabbitATP Binding Cassette Subfamily F Member 3 (ABCF3)UnconjugatedELISA, IHC162.520 µgQ9NUQ8RUO
AbbexaABCF3abx312080ATP Binding Cassette Subfamily F Member 3 (ABCF3) Antibody (HRP)HumanPolyclonalRabbitATP Binding Cassette Subfamily F Member 3 (ABCF3)HRPELISA162.520 µgQ9NUQ8RUO
AbbexaABCF3abx038088ATP Binding Cassette Subfamily F Member 3 (ABCF3) AntibodyHumanPolyclonalRabbitATP Binding Cassette Subfamily F Member 3 (ABCF3)UnconjugatedELISA, WB, IHC337.5100 µgBC051754RUO
AbbexaABCF3abx312082ATP Binding Cassette Subfamily F Member 3 (ABCF3) Antibody (Biotin)HumanPolyclonalRabbitATP Binding Cassette Subfamily F Member 3 (ABCF3)BiotinELISA162.520 µgQ9NUQ8RUO
AbbexaABCF3abx312081ATP Binding Cassette Subfamily F Member 3 (ABCF3) Antibody (FITC)HumanPolyclonalRabbitATP Binding Cassette Subfamily F Member 3 (ABCF3)FITC162.520 µgQ9NUQ8RUO
AbbexaABCF3abx038087ATP Binding Cassette Subfamily F Member 3 (ABCF3) AntibodyHumanPolyclonalRabbitATP Binding Cassette Subfamily F Member 3 (ABCF3)UnconjugatedELISA, WB, IHC337.5100 µgRUO
AbbexaABCF3abx241170ATP Binding Cassette Subfamily F Member 3 (ABCF3) AntibodyHumanPolyclonalRabbitATP Binding Cassette Subfamily F Member 3 (ABCF3)UnconjugatedELISA, IHC25050 µlQ9NUQ8RUO
AbbexaABCF3abx241169ATP Binding Cassette Subfamily F Member 3 (ABCF3) AntibodyHumanPolyclonalRabbitATP Binding Cassette Subfamily F Member 3 (ABCF3)UnconjugatedELISA, IHC25050 µlQ9NUQ8RUO
AbbexaABCF1abx130580ATP Binding Cassette Transporter F1 (ABCF1) AntibodyMousePolyclonalRabbitATP Binding Cassette Transporter F1 (ABCF1)UnconjugatedWB, IHC, IF/ICC275100 µlRUO

Proteins and Peptides

providerCodereferencenameoriginexpressionhostconjugationtested applicationspricesize 1uniprot idstatus
AbbexaABCF1abx650392Human ATP Binding Cassette Transporter F1 (ABCF1) ProteinHumanRecombinantE. coliUnconjugatedWB, SDS-PAGE20010 µgQ8NE71RUO
AbbexaABCF1abx650393Mouse ATP Binding Cassette Transporter F1 (ABCF1) ProteinMouseRecombinantE. coliUnconjugatedWB, SDS-PAGE212.510 µgQ6P542RUO
FineTestABCF2P0486Recombinant Human ABCF2HumanRecombinantE.ColiWestern Blot, ELISA50μgQ9UG63RUO
AbbexaABCF2abx650391Human ATP Binding Cassette Subfamily F Member 2 (ABCF2) ProteinHumanRecombinantE. coliUnconjugatedWB, SDS-PAGE20010 µgQ9UG63RUO

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