ABCF1 antibody
Contáctenos para saber el precio
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
935106861
info@markelab.com
name
ABCF1 antibody
category
Primary Antibodies
provider
FineTest
reference
FNab00040
tested applications
ELISA, WB, IP
Description
Isoform 2 is required for efficient Cap-and IRES-mediated mRNA translation initiation. Isoform 2 is not involved in the ribosome biogenesis.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | ATP-binding cassette, sub-family F(GCN20), member 1 (ABCF1) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1:500-1:5000; IP: 1:200-1:2000; IF: 1:20-1:200 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 95 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IP |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q8NE71 |
| Gene ID | 23 |
| Alias | ABC27,ABC50 |
| Background | Antibody anti-ABCF1 |
| Status | RUO |
| Note | Mol. Weight 95 kDa |
Descripción
ABCF1 is an ATP-binding cassette (ABC) protein that lacks transmembrane domains, distinguishing it from traditional ABC transporters involved in substrate transport. Instead, ABCF1 functions primarily in regulating translation initiation and immune responses. It facilitates the assembly of the translation machinery by interacting with ribosomal subunits, ensuring efficient protein synthesis. ABCF1 is ubiquitously expressed but is particularly abundant in immune cells, where it plays a role in regulating the production of inflammatory cytokines, such as tumor necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6). Its involvement in inflammatory signaling pathways has implicated it in autoimmune diseases, including rheumatoid arthritis, where dysregulation of ABCF1 contributes to chronic inflammation. Additionally, ABCF1 is associated with cancer progression due to its role in sustaining protein homeostasis and immune signaling in the tumor microenvironment. Dysregulation of ABCF1 can disrupt translational control and immune balance, highlighting its significance in both cellular function and disease pathogenesis.
Related Products
ABCF1 antibody
Isoform 2 is required for efficient Cap-and IRES-mediated mRNA translation initiation. Isoform 2 is not involved in the ribosome biogenesis.
Ver Producto
ATP Binding Cassette Subfamily F Member 1 (ABCF1) Antibody
Rabbit polyclonal antibody against ABCF1 protein. Immunogen region is C-terminal.
Ver Producto
ATP Binding Cassette Subfamily F Member 1 (ABCF1) Antibody
Rabbit Polyclonal against the ABCF1 protein.
Ver Producto