Mouse ATP Binding Cassette Transporter F1 (ABCF1) Protein
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935106861
info@markelab.com
Precio
221€ (10 µg)
Protein ABCF1
proveedor
Abbexareference
abx650393Tested Applications
WB, SDS-PAGEreactivity
status
RUOclonality
Descripción
Mouse ABCF1 Protein is a recombinant Mouse protein produced in a Prokaryotic expression system (E. coli).
Background
ABCF1 is an ATP-binding cassette (ABC) protein that lacks transmembrane domains, distinguishing it from traditional ABC transporters involved in substrate transport. Instead, ABCF1 functions primarily in regulating translation initiation and immune responses. It facilitates the assembly of the translation machinery by interacting with ribosomal subunits, ensuring efficient protein synthesis. ABCF1 is ubiquitously expressed but is particularly abundant in immune cells, where it plays a role in regulating the production of inflammatory cytokines, such as tumor necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6). Its involvement in inflammatory signaling pathways has implicated it in autoimmune diseases, including rheumatoid arthritis, where dysregulation of ABCF1 contributes to chronic inflammation. Additionally, ABCF1 is associated with cancer progression due to its role in sustaining protein homeostasis and immune signaling in the tumor microenvironment. Dysregulation of ABCF1 can disrupt translational control and immune balance, highlighting its significance in both cellular function and disease pathogenesis.
Características del producto
category
Proteins and Peptides
origin
Mouse
host
E. coli
immunogen target
ATP Binding Cassette Transporter F1 (ABCF1)
host
E. coli
conjugation
Unconjugated
form
Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
tested applications
WB, SDS-PAGE
size 1
10 µg
size 2
50 µg
size 3
100 µg
size 4
200 µg
size 5
500 µg
observerd MW
Molecular Weight: Calculated MW: 28.5 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Leu617-Asp837 Tag: N-terminal His tag
expression
Recombinant
purity
> 95%
buffer
Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.
storage
Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
or code
ABCF1
dry ice
No
availability
Shipped within 5-7 working days.
alias
ABC27,ABC50
uniprot id
note
This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.
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