ABCF2 antibody
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Description
This gene encodes a member of the ATP-binding cassette (ABC) transporter superfamily. ATP-binding casette proteins transport various molecules across extra- and intracellular membranes. Alterations in this gene may be involved in cancer progression. Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 3 and 7.
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Product specifications
| Category | Primary Antibodies |
| Immunogen Target | ATP-binding cassette, sub-family F (GCN20), member 2 (ABCF2) |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Recommended Dilution | WB: 1:500 - 1:2000; IHC: 1:20 - 1:200 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 72 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IHC |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q9UG63 |
| Gene ID | 10061 |
| Alias | ABC28,HUSSY-18,HUSSY18 |
| Background | Antibody anti-ABCF2 |
| Status | RUO |
| Note | Mol. Weight 72 kDa |
Descripción
ABCF2 is an atypical ATP-binding cassette protein that lacks transmembrane domains, functioning in intracellular processes such as cellular stress response and protein homeostasis. It is expressed in various tissues, with notable activity in the liver and kidneys, where it may protect cells from oxidative damage and environmental toxins. ABCF2 is believed to interact with the ubiquitin-proteasome system, regulating protein degradation and turnover, which is critical for maintaining cellular proteostasis under stress conditions. Recent evidence suggests that ABCF2 may also play a role in cancer, contributing to tumor progression and survival by modulating stress response pathways and protein stability. Its involvement in cellular adaptation to metabolic and oxidative stress underscores its importance in maintaining cell viability and function. Dysregulation of ABCF2 has been linked to resistance to chemotherapeutic agents, further emphasizing its potential as a therapeutic target. Despite growing evidence of its roles, further research is needed to elucidate its precise mechanisms in cellular metabolism and disease.
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