ATP Binding Cassette Subfamily F Member 2 (ABCF2) Antibody
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Description
ABCF2 Antibody is a Rabbit Polyclonal antibody against ABCF2. This gene encodes a member of the ATP-binding cassette (ABC) transporter superfamily. ATP-binding casette proteins transport various molecules across extra- and intracellular membranes. Alterations in this gene may be involved in cancer progression. Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 3 and 7.
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Product specifications
| Category | Primary Antibodies |
| Immunogen Target | ATP Binding Cassette Subfamily F Member 2 (ABCF2) |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Recommended Dilution | ELISA: 1 µg/ml, WB: 1/500 - 1/2000, IF/ICC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by affinity chromatography. |
| Size 1 | 20 µl |
| Size 2 | 100 µl |
| Size 3 | 2 × 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB, IF/ICC |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9UG63 |
| Gene ID | 10061 |
| NCBI Accession | NP_005683.2 |
| Alias | ABC28,HUSSY-18,HUSSY18 |
| Background | Antibody anti-ABCF2 |
| Status | RUO |
| Note | Concentration: > 0.2 mg/ml - |
Descripción
ABCF2 is an atypical ATP-binding cassette protein that lacks transmembrane domains, functioning in intracellular processes such as cellular stress response and protein homeostasis. It is expressed in various tissues, with notable activity in the liver and kidneys, where it may protect cells from oxidative damage and environmental toxins. ABCF2 is believed to interact with the ubiquitin-proteasome system, regulating protein degradation and turnover, which is critical for maintaining cellular proteostasis under stress conditions. Recent evidence suggests that ABCF2 may also play a role in cancer, contributing to tumor progression and survival by modulating stress response pathways and protein stability. Its involvement in cellular adaptation to metabolic and oxidative stress underscores its importance in maintaining cell viability and function. Dysregulation of ABCF2 has been linked to resistance to chemotherapeutic agents, further emphasizing its potential as a therapeutic target. Despite growing evidence of its roles, further research is needed to elucidate its precise mechanisms in cellular metabolism and disease.
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This gene encodes a member of the ATP-binding cassette (ABC) transporter superfamily. ATP-binding casette proteins transport various molecules across extra- and intracellular membranes. Alterations in this gene may be involved in cancer progression. Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 3 and 7.
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ABCF2 Antibody is a Rabbit Polyclonal antibody against ABCF2. This gene encodes a member of the ATP-binding cassette (ABC) transporter superfamily. ATP-binding casette proteins transport various molecules across extra- and intracellular membranes. Alterations in this gene may be involved in cancer progression. Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 3 and 7.
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