Family main features
UBASH3B (Ubiquitin-associated and SH3 domain-containing B) is a protein that plays a crucial role in the regulation of signaling pathways related to immune responses and cellular processes such as proliferation and apoptosis. UBASH3B, also known as STS-1 (Suppressor of T-cell receptor signaling 1), is part of the TULA (T-cell ubiquitin ligand) family of proteins, which are characterized by the presence of ubiquitin-associated (UBA) domains and Src homology 3 (SH3) domains. These domains facilitate the interaction of UBASH3B with other proteins and its involvement in the regulation of ubiquitination, a post-translational modification process critical for protein degradation and signaling. UBASH3B has been shown to act as a negative regulator of T-cell receptor (TCR) signaling, thereby modulating immune responses. Additionally, UBASH3B is involved in various cellular pathways that influence cell survival, proliferation, and differentiation, making it significant in both normal physiological and pathological conditions, including immune disorders and cancer.
UBASH3B is characterized by several distinct structural domains:
UBASH3B belongs to the TULA family of proteins, which includes TULA-1 (UBASH3A) and TULA-2 (UBASH3B). These proteins share structural similarities and functional characteristics but can have distinct roles in different cellular contexts. UBASH3B specifically has been more extensively studied for its role in immune cell signaling and regulation.
UBASH3B plays multiple roles in cellular signaling:
Dysregulation of UBASH3B is associated with several clinical conditions:
UBASH3B (Ubiquitin-associated and SH3 domain-containing B) is an essential protein involved in the regulation of immune signaling and cellular processes such as proliferation and apoptosis. It features distinct structural domains, including UBA and SH3 domains, which facilitate its interactions with other proteins and its role in ubiquitination. As a negative regulator of TCR signaling, UBASH3B modulates immune responses and is involved in various cellular pathways that impact cell survival and differentiation. Dysregulation of UBASH3B is linked to autoimmune diseases, cancer, and other immune disorders, highlighting its significance in both normal physiology and disease states. Understanding the molecular mechanisms of UBASH3B can provide insights into potential therapeutic targets for these conditions.
Ubiquitin associated and SH3 domain containing B (UBASH3B)
STS-1, STS1, TULA-2, TULA2, p70,Cbl-interacting protein p70
Ubiquitin associated and SH3 domain containing A (UBASH3A)
UBASH3A, CLIP4, STS-2, TULA, TULA-1,Cbl-interacting protein 4
En la tabla siguiente se muestra una comparativa de todos los reactivos disponibles en nuestro catálogo (Primary Antibodies, ELISA Kits) relacionados con UBASH3 - Ubiquitin associated and SH3 domain containing
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Esta página contiene 20 reactivos de las marcas (Abbexa, FineTest) que se corresponden con tu busqueda
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provider | Code | reference | name | reactivity | sample type | assay type | test range | sensitivity | price | size 1 | uniprot id | status |
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Abbexa | UBASH3A | abx384062 | Human Ubiquitin-Associated And SH3 Domain-Containing Protein A (UBASH3A) ELISA Kit | Human | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 0.313 ng/ml - 20 ng/ml | < 0.188 ng/ml | 687.5 | 96 tests | P57075 | RUO |
Abbexa | UBASH3B | abx552405 | Human Ubiquitin-associated and SH3 domain-containing protein B (UBASH3B) ELISA Kit | Human | Tissue homogenates,Cell lysates,Other biological fluids | 0.156 ng/ml - 10 ng/ml | 687.5 | 96 tests | Q8TF42 | RUO | ||
Abbexa | UBASH3A | abx552404 | Mouse Ubiquitin-associated and SH3 domain-containing protein A (UBASH3A) ELISA Kit | Mouse | Tissue homogenates,Cell lysates,Other biological fluids | 0.156 ng/ml - 10 ng/ml | 687.5 | 96 tests | Q3V3E1 | RUO | ||
Abbexa | UBASH3B | abx552406 | Mouse Ubiquitin-associated and SH3 domain-containing protein B (UBASH3B) ELISA Kit | Mouse | Tissue homogenates,Cell lysates,Other biological fluids | 0.156 ng/ml - 10 ng/ml | 687.5 | 96 tests | Q8BGG7 | RUO |
provider | Code | reference | name | reactivity | clonality | host | immunogen target | isotype | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
FineTest | UBASH3A | FNab09151 | anti- UBASH3B/STS 1 antibody | human | polyclonal | Rabbit | ubiquitin associated and SH3 domain containing, B | IgG | Unconjugated | ELISA, WB, IHC, IF | 100µg | Q8TF42 | RUO | |
FineTest | UBASH3A | FNab09150 | anti- UBASH3A-Specific antibody | human | polyclonal | Rabbit | ubiquitin associated and SH3 domain containing, A | IgG | Unconjugated | ELISA, WB, IF, IP | 100µg | P57075 | RUO | |
Abbexa | UBASH3A | abx037052 | Ubiquitin-Associated And SH3 Domain-Containing Protein A (UBASH3A) Antibody | Human | Polyclonal | Rabbit | Ubiquitin-Associated And SH3 Domain-Containing Protein A (UBASH3A) | Unconjugated | ELISA, WB, IHC | 337.5 | 100 µg | RUO | ||
Abbexa | UBASH3A | abx338210 | Ubiquitin-Associated And SH3 Domain-Containing Protein A (UBASH3A) Antibody (FITC) | Human | Polyclonal | Rabbit | Ubiquitin-Associated And SH3 Domain-Containing Protein A (UBASH3A) | FITC | 162.5 | 20 µg | P57075 | RUO | ||
Abbexa | UBASH3A | abx338211 | Ubiquitin-Associated And SH3 Domain-Containing Protein A (UBASH3A) Antibody (Biotin) | Human | Polyclonal | Rabbit | Ubiquitin-Associated And SH3 Domain-Containing Protein A (UBASH3A) | Biotin | ELISA | 162.5 | 20 µg | P57075 | RUO | |
Abbexa | UBASH3A | abx324083 | Ubiquitin-Associated And SH3 Domain-Containing Protein A (UBASH3A) Antibody | Human | Polyclonal | Rabbit | Ubiquitin-Associated And SH3 Domain-Containing Protein A (UBASH3A) | Unconjugated | ELISA, WB | 187.5 | 50 µg | P57075 | RUO | |
Abbexa | UBASH3A | abx333811 | Ubiquitin-Associated And SH3 Domain-Containing Protein A (UBASH3A) Antibody | Human | Polyclonal | Rabbit | Ubiquitin-Associated And SH3 Domain-Containing Protein A (UBASH3A) | Unconjugated | ELISA, WB, IF/ICC | 162.5 | 20 µg | P57075 | RUO | |
Abbexa | UBASH3A | abx014929 | Ubiquitin-Associated And SH3 Domain-Containing Protein A (UBASH3A) Antibody | Human | Polyclonal | Rabbit | Ubiquitin-Associated And SH3 Domain-Containing Protein A (UBASH3A) | Unconjugated | ELISA, WB | 43.75 | 10 µg | P57075 | RUO | |
Abbexa | UBASH3A | abx338209 | Ubiquitin-Associated And SH3 Domain-Containing Protein A (UBASH3A) Antibody (HRP) | Human | Polyclonal | Rabbit | Ubiquitin-Associated And SH3 Domain-Containing Protein A (UBASH3A) | HRP | ELISA | 162.5 | 20 µg | P57075 | RUO | |
Abbexa | UBASH3A | abx116408 | Ubiquitin Associated And Sh3 Domain Containing, A (UBASH3A) Antibody | Human | Polyclonal | Rabbit | Ubiquitin Associated And Sh3 Domain Containing, A (UBASH3A) | Unconjugated | ELISA, WB, IF/ICC | 612.5 | 100 µl | P57075 | RUO | |
Abbexa | UBASH3A | abx239150 | UBASH3A-Specific Antibody | Human | Polyclonal | Rabbit | UBASH3A-Specific | Unconjugated | ELISA, WB, IF/ICC, IP | 350 | 100 µg | P57075 | RUO | |
Abbexa | UBASH3B | abx320812 | Ubiquitin-Associated And SH3 Domain-Containing Protein B (UBASH3B) Antibody | Human | Polyclonal | Rabbit | Ubiquitin-Associated And SH3 Domain-Containing Protein B (UBASH3B) | Unconjugated | ELISA, IHC | 250 | 50 µl | Q8TF42 | RUO | |
Abbexa | UBASH3B | abx239151 | Ubiquitin-Associated And SH3 Domain-Containing Protein B (UBASH3B) Antibody | Human | Polyclonal | Rabbit | Ubiquitin-Associated And SH3 Domain-Containing Protein B (UBASH3B) | Unconjugated | ELISA, WB, IHC, IF/ICC | 350 | 100 µg | Q8TF42 | RUO | |
Abbexa | UBASH3B | abx005392 | Ubiquitin-Associated And SH3 Domain-Containing Protein B (UBASH3B) Antibody | Human | Polyclonal | Rabbit | Ubiquitin-Associated And SH3 Domain-Containing Protein B (UBASH3B) | Unconjugated | WB, IHC, IF/ICC | 175 | 20 µl | Q8TF42 | RUO | |
Abbexa | UBASH3B | abx116409 | Ubiquitin Associated And Sh3 Domain Containing, B (UBASH3B) Antibody | Human | Polyclonal | Rabbit | Ubiquitin Associated And Sh3 Domain Containing, B (UBASH3B) | Unconjugated | ELISA, WB, IHC | 612.5 | 100 µl | Q8TF42 | RUO | |
Abbexa | UBASH3A | abx030823 | Ubiquitin-Associated And SH3 Domain-Containing Protein A (UBASH3A) Antibody | Mouse | Polyclonal | Rabbit | Ubiquitin-Associated And SH3 Domain-Containing Protein A (UBASH3A) | Unconjugated | ELISA, WB | 250 | 80 µl | P57075 | RUO |
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