Ubiquitin-Associated And SH3 Domain-Containing Protein B (UBASH3B) Antibody
312€ (60 µl)
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935106861
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name
Ubiquitin-Associated And SH3 Domain-Containing Protein B (UBASH3B) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx005392
tested applications
IHC, IF/ICC
Description
UBASH3B Antibody is a Rabbit Polyclonal antibody against UBASH3B. This gene encodes a protein that contains a ubiquitin associated domain at the N-terminus, an SH3 domain, and a C-terminal domain with similarities to the catalytic motif of phosphoglycerate mutase. The encoded protein was found to inhibit endocytosis of epidermal growth factor receptor (EGFR) and platelet-derived growth factor receptor.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Ubiquitin-Associated And SH3 Domain-Containing Protein B (UBASH3B) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | IHC-P: 1/50 - 1/200, IF/ICC: 1/50 - 1/100. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by affinity chromatography. |
| Size 1 | 60 µl |
| Size 2 | 120 µl |
| Size 3 | 200 µl |
| Form | Liquid |
| Tested Applications | IHC, IF/ICC |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q8TF42 |
| Gene ID | 84959 |
| NCBI Accession | NP_116262.2 |
| Alias | STS-1, STS1, TULA-2, TULA2, p70,Cbl-interacting protein p70 |
| Background | Antibody anti-UBASH3B |
| Status | RUO |
| Note | Concentration: 1 mg/ml - |
Descripción
UBASH3B, also known as STS-1 (Suppressor of T-cell receptor signaling 1), is a negative regulator of T-cell receptor (TCR) signaling that functions by dephosphorylating signaling intermediates and attenuating downstream activation of NF-κB and MAPK pathways. It contains ubiquitin-associated (UBA) and SH3 domains that mediate interactions with signaling proteins and ubiquitinated molecules, promoting the regulation of protein stability and turnover. UBASH3B is expressed predominantly in immune cells, where it plays a role in T-cell activation, immune tolerance, and inflammation control. Dysregulation of UBASH3B is associated with autoimmune diseases and impaired immune responses due to excessive TCR signaling. Knockout studies reveal hyperactive T-cell signaling, increased cytokine production, and heightened immune activation, underscoring its role in maintaining immune homeostasis by regulating TCR signaling and protein ubiquitination pathways.
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