Ubiquitin-Associated And SH3 Domain-Containing Protein A (UBASH3A) Antibody (HRP)
169€ (20 µg)
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Name
Ubiquitin-Associated And SH3 Domain-Containing Protein A (UBASH3A) Antibody (HRP)
Category
Primary Antibodies
Provider
Abbexa
Reference
abx338209
Tested Applications
ELISA
Description
UBASH3A Antibody (HRP) is a Rabbit Polyclonal against UBASH3A.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Ubiquitin-Associated And SH3 Domain-Containing Protein A (UBASH3A) Immunogen: Recombinant Human Ubiquitin-associated and SH3 domain-containing protein A protein (287-455AA). |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | HRP |
| Isotype | IgG |
| Purity | > 95% |
| Purification | Purified by Protein G. |
| Size 1 | 20 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Tested Applications | ELISA |
| Buffer | 0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid exposure to light. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P57075 |
| Gene ID | 53347 |
| Alias | UBASH3A, CLIP4, STS-2, TULA, TULA-1,Cbl-interacting protein 4 |
| Background | Antibody anti-UBASH3A |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
Ubiquitin-associated and SH3 domain-containing A (UBASH3A), also known as TULA or Sts-2, is a protein involved in the regulation of intracellular signaling pathways, particularly those linked to immune receptor signaling and T-cell activation. It contains an SH3 domain, which mediates interactions with other signaling proteins, and a ubiquitin-associated domain, enabling it to influence protein degradation and signaling processes. UBASH3A functions as a negative regulator of T-cell receptor (TCR) signaling by dephosphorylating key signaling molecules like Zap-70 and LAT, thereby modulating immune responses and preventing overactivation of T cells. It plays a role in maintaining immune tolerance and homeostasis, with mutations or dysregulation of UBASH3A associated with autoimmune diseases such as type 1 diabetes, where loss of regulation contributes to aberrant immune activation. Additionally, UBASH3A has been implicated in regulating endocytic trafficking and downregulation of surface receptors, influencing cellular responses to extracellular stimuli. Its expression and activity are tightly regulated, and it interacts with multiple partners to fine-tune immune signaling networks. Emerging studies are investigating UBASH3A as a potential target for modulating immune responses in autoimmune and inflammatory conditions.
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