Ubiquitin Associated And Sh3 Domain Containing, B (UBASH3B) Antibody
637€ (100 µl)
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935106861
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name
Ubiquitin Associated And Sh3 Domain Containing, B (UBASH3B) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx116409
tested applications
ELISA, WB, IHC
Description
Ubiquitin Associated And Sh3 Domain Containing, B Antibody is a Rabbit Polyclonal antibody against Ubiquitin Associated And Sh3 Domain Containing, B.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Ubiquitin Associated And Sh3 Domain Containing, B (UBASH3B) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Antigen Affinity Chromatography. |
| Size 1 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC |
| Buffer | PBS, pH 7.3, containing 0.02% Sodium Azide and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q8TF42 |
| Gene ID | 84959 |
| OMIM | 609201 |
| Alias | STS-1, STS1, TULA-2, TULA2, p70,Cbl-interacting protein p70 |
| Background | Antibody anti-UBASH3B |
| Status | RUO |
Descripción
UBASH3B, also known as STS-1 (Suppressor of T-cell receptor signaling 1), is a negative regulator of T-cell receptor (TCR) signaling that functions by dephosphorylating signaling intermediates and attenuating downstream activation of NF-κB and MAPK pathways. It contains ubiquitin-associated (UBA) and SH3 domains that mediate interactions with signaling proteins and ubiquitinated molecules, promoting the regulation of protein stability and turnover. UBASH3B is expressed predominantly in immune cells, where it plays a role in T-cell activation, immune tolerance, and inflammation control. Dysregulation of UBASH3B is associated with autoimmune diseases and impaired immune responses due to excessive TCR signaling. Knockout studies reveal hyperactive T-cell signaling, increased cytokine production, and heightened immune activation, underscoring its role in maintaining immune homeostasis by regulating TCR signaling and protein ubiquitination pathways.
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