anti- UBASH3B/STS 1 antibody
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Description
This gene encodes a protein that contains a ubiquitin associated domain at the N-terminus, an SH3 domain, and a C-terminal domain with similarities to the catalytic motif of phosphoglycerate mutase. The encoded protein was found to inhibit endocytosis of epidermal growth factor receptor (EGFR) and platelet-derived growth factor receptor.
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Product specifications
| Category | Primary Antibodies |
| Immunogen Target | ubiquitin associated and SH3 domain containing, B |
| Host | Rabbit |
| Reactivity | human,mouse,rat |
| Recommended Dilution | WB: 1:500 - 1:2000; IHC: 1:50 - 1:200; IF: 1:50 - 1:100 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 73 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IHC, IF |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 12 months (Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q8TF42 |
| Gene ID | 84959 |
| Alias | UBASH3A, CLIP4, STS-2, TULA, TULA-1,Cbl-interacting protein 4 |
| Background | Antibody anti-UBASH3A |
| Status | RUO |
| Note | This product is for research use only. |
Descripción
Ubiquitin-associated and SH3 domain-containing A (UBASH3A), also known as TULA or Sts-2, is a protein involved in the regulation of intracellular signaling pathways, particularly those linked to immune receptor signaling and T-cell activation. It contains an SH3 domain, which mediates interactions with other signaling proteins, and a ubiquitin-associated domain, enabling it to influence protein degradation and signaling processes. UBASH3A functions as a negative regulator of T-cell receptor (TCR) signaling by dephosphorylating key signaling molecules like Zap-70 and LAT, thereby modulating immune responses and preventing overactivation of T cells. It plays a role in maintaining immune tolerance and homeostasis, with mutations or dysregulation of UBASH3A associated with autoimmune diseases such as type 1 diabetes, where loss of regulation contributes to aberrant immune activation. Additionally, UBASH3A has been implicated in regulating endocytic trafficking and downregulation of surface receptors, influencing cellular responses to extracellular stimuli. Its expression and activity are tightly regulated, and it interacts with multiple partners to fine-tune immune signaling networks. Emerging studies are investigating UBASH3A as a potential target for modulating immune responses in autoimmune and inflammatory conditions.
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