anti- UBASH3A-Specific antibody

Descripción

UBASH3A gene encodes ubiquitin-associated and SH3 domain-containing protein A(UBASH3A) also known as T-cell ubiquitin ligand 1(TULA1) which is one of two family members belonging to the T-cell ubiquitin ligand(TULA) family. UBASH3A gene expression is limited to only a few tissues, with its highest expression in spleen, peripheral blood leukocytes, and bone marrow. UBASH3A protein is associated with c-Cbl and ubiquitylated proteins and has been implicated in the regulation of signaling mediated by protein-tyrosine kinases oth family members can negatively regulate T-cell signaling. UBASH3A can facilitate growth factor withdrawal-induced apoptosis in T cells via its interaction with apoptosis-inducing factor(AIF). This antibody is UBASH3A-specific.