Human Ubiquitin-associated and SH3 domain-containing protein B (UBASH3B) ELISA Kit
715€ (96 tests)
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935106861
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name
Human Ubiquitin-associated and SH3 domain-containing protein B (UBASH3B) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx552405
tested applications
ELISA
Description
Human Ubiquitin-associated and SH3 domain-containing protein B (UBASH3B) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human Ubiquitin-associated and SH3 domain-containing protein B (UBASH3B) concentrations in tissue homogenates, cell lysates and other biological fluids.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | ELISA Kits |
| Immunogen Target | Ubiquitin-associated and SH3 domain-containing protein B (UBASH3B) |
| Reactivity | Human |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Test Range | 0.156 ng/ml - 10 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-15 working days. The validity for this kit is 6 months. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | Q8TF42 |
| OMIM | 609201 |
| Alias | STS-1, STS1, TULA-2, TULA2, p70,Cbl-interacting protein p70 |
| Background | Elisa kits for UBASH3B |
| Status | RUO |
| Note | Validity: The validity for this kit is 6 months. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
UBASH3B, also known as STS-1 (Suppressor of T-cell receptor signaling 1), is a negative regulator of T-cell receptor (TCR) signaling that functions by dephosphorylating signaling intermediates and attenuating downstream activation of NF-κB and MAPK pathways. It contains ubiquitin-associated (UBA) and SH3 domains that mediate interactions with signaling proteins and ubiquitinated molecules, promoting the regulation of protein stability and turnover. UBASH3B is expressed predominantly in immune cells, where it plays a role in T-cell activation, immune tolerance, and inflammation control. Dysregulation of UBASH3B is associated with autoimmune diseases and impaired immune responses due to excessive TCR signaling. Knockout studies reveal hyperactive T-cell signaling, increased cytokine production, and heightened immune activation, underscoring its role in maintaining immune homeostasis by regulating TCR signaling and protein ubiquitination pathways.
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