Ubiquitin-Associated And SH3 Domain-Containing Protein A (UBASH3A) Antibody

Product specifications

Primary Antibodies

Ubiquitin-Associated And SH3 Domain-Containing Protein A (UBASH3A)

Rabbit

Human

ELISA: 1/20000 - 1/80000, WB: 1/500 - 1/2000, IHC: 1/100 - 1/200. Optimal dilutions/concentrations should be determined by the end user.

Polyclonal

Unconjugated

IgG

Purified by antigen affinity column chromatography.

100 µg

1 mg

Lyophilized

ELISA, WB, IHC

Prior to lyophilization: 1% BSA and 0.02% NaN3.

Shipped within 7-15 working days.

Store at -20 °C. Avoid repeated freeze/thaw cycles.

No

UBASH3A, CLIP4, STS-2, TULA, TULA-1,Cbl-interacting protein 4

Antibody anti-UBASH3A

RUO

Concentration: Lyophilized form: Not applicable.  After reconstitution: 1 mg/ml. - 

Descripción

Ubiquitin-associated and SH3 domain-containing A (UBASH3A), also known as TULA or Sts-2, is a protein involved in the regulation of intracellular signaling pathways, particularly those linked to immune receptor signaling and T-cell activation. It contains an SH3 domain, which mediates interactions with other signaling proteins, and a ubiquitin-associated domain, enabling it to influence protein degradation and signaling processes. UBASH3A functions as a negative regulator of T-cell receptor (TCR) signaling by dephosphorylating key signaling molecules like Zap-70 and LAT, thereby modulating immune responses and preventing overactivation of T cells. It plays a role in maintaining immune tolerance and homeostasis, with mutations or dysregulation of UBASH3A associated with autoimmune diseases such as type 1 diabetes, where loss of regulation contributes to aberrant immune activation. Additionally, UBASH3A has been implicated in regulating endocytic trafficking and downregulation of surface receptors, influencing cellular responses to extracellular stimuli. Its expression and activity are tightly regulated, and it interacts with multiple partners to fine-tune immune signaling networks. Emerging studies are investigating UBASH3A as a potential target for modulating immune responses in autoimmune and inflammatory conditions.

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