Ubiquitin-Associated And SH3 Domain-Containing Protein A (UBASH3A) Antibody (FITC)

Este producto es parte de UBASH3 - Ubiquitin associated and SH3 domain containing
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169€ (20 µg)

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935106861
info@markelab.com
name
Ubiquitin-Associated And SH3 Domain-Containing Protein A (UBASH3A) Antibody (FITC)
category
Primary Antibodies
provider
Abbexa
reference
abx338210

Description

UBASH3A Antibody (FITC) is a Rabbit Polyclonal against UBASH3A.

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Primary Antibodies
Immunogen Target
Ubiquitin-Associated And SH3 Domain-Containing Protein A (UBASH3A)
Host
Rabbit
Reactivity
Human
Recommended Dilution
Optimal dilutions/concentrations should be determined by the end user.
Clonality
Polyclonal
Conjugation
FITC
Isotype
IgG
Purity
> 95%
Purification
Purified by Protein G.
Size 1
20 µg
Size 2
50 µg
Size 3
100 µg
Size 4
200 µg
Size 5
1 mg
Form
Liquid
Buffer
0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol.
Availability
Shipped within 5-10 working days.
Storage
Aliquot and store at -20°C. Avoid exposure to light. Avoid repeated freeze/thaw cycles.
Dry Ice
No
UniProt ID
P57075
Gene ID
53347
Alias
UBASH3A, CLIP4, STS-2, TULA, TULA-1,Cbl-interacting protein 4
Background
Antibody anti-UBASH3A
Status
RUO

Descripción

Ubiquitin-associated and SH3 domain-containing A (UBASH3A), also known as TULA or Sts-2, is a protein involved in the regulation of intracellular signaling pathways, particularly those linked to immune receptor signaling and T-cell activation. It contains an SH3 domain, which mediates interactions with other signaling proteins, and a ubiquitin-associated domain, enabling it to influence protein degradation and signaling processes. UBASH3A functions as a negative regulator of T-cell receptor (TCR) signaling by dephosphorylating key signaling molecules like Zap-70 and LAT, thereby modulating immune responses and preventing overactivation of T cells. It plays a role in maintaining immune tolerance and homeostasis, with mutations or dysregulation of UBASH3A associated with autoimmune diseases such as type 1 diabetes, where loss of regulation contributes to aberrant immune activation. Additionally, UBASH3A has been implicated in regulating endocytic trafficking and downregulation of surface receptors, influencing cellular responses to extracellular stimuli. Its expression and activity are tightly regulated, and it interacts with multiple partners to fine-tune immune signaling networks. Emerging studies are investigating UBASH3A as a potential target for modulating immune responses in autoimmune and inflammatory conditions.

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