Family main features
The MYC proto-oncogene, a member of the basic helix-loop-helix (bHLH) transcription factor family, is a critical regulator of cell growth, proliferation, and apoptosis. MYC, located on chromosome 8q24, encodes a nuclear protein that influences the expression of a vast array of target genes involved in various cellular processes. Discovered in the early 1980s, MYC was initially identified as a gene implicated in avian myelocytomatosis virus-induced leukemia. Since then, extensive research has elucidated its pivotal role in normal cellular functions and its frequent dysregulation in cancer.
MYC acts as a transcription factor by binding to E-box sequences in the promoter regions of target genes. It forms heterodimers with another bHLH protein, MAX, which is essential for its DNA-binding activity. The MYC/MAX complex regulates the transcription of genes involved in cell cycle progression, metabolism, ribosome biogenesis, and protein synthesis. Consequently, MYC is a master regulator of cellular growth and proliferation.
The MYC protein consists of several distinct domains that contribute to its function:
The structural integrity and interactions of these domains are essential for MYC's function as a transcription factor. Alterations in any of these regions can significantly impact MYC's activity and its role in cellular processes.
MYC belongs to the MYC family of proto-oncogenes, which includes three main members:
These MYC family members share structural similarities and functional characteristics but have distinct expression patterns and roles in different tissues and types of cancer.
MYC is a central regulator of cellular physiology, influencing various biological processes:
The dysregulation of MYC is implicated in a wide array of cancers. Overexpression, gene amplification, and translocations involving MYC lead to its constitutive activation, driving uncontrolled cell proliferation and tumorigenesis. Clinical issues related to MYC dysregulation include:
The MYC proto-oncogene is a critical transcription factor involved in regulating cell growth, proliferation, metabolism, and apoptosis. Structurally, it features distinct domains essential for its DNA-binding and transactivation functions. MYC dysregulation is a hallmark of many cancers, making it a significant focus of oncological research. The understanding of MYC's biological roles and its involvement in cancer has led to the exploration of various therapeutic strategies aimed at targeting this oncogene. Continued research on MYC's mechanisms and interactions will enhance our ability to develop effective cancer therapies and improve clinical outcomes for patients with MYC-driven malignancies.
MYC proto-oncogene, bHLH transcription factor (MYC)
MRTL,MYCC,c-Myc,bHLHe39,Transcription factor p64,Proto-oncogene c-Myc,Class E basic helix-loop-helix protein 39
En la tabla siguiente se muestra una comparativa de todos los reactivos disponibles en nuestro catálogo (Proteins and Peptides, ELISA Kits, Primary Antibodies, CLIA Kits) relacionados con MYC proto-oncogene, bHLH transcription factor
Se muestran ordenados por categorías para poder comparar cómodamente sus características principales. Esta tabla, que contiene un enlace con la ficha de cada producto, es exportable a Excel.
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provider | Code | reference | name | reactivity | sample type | assay type | test range | sensitivity | price | size 1 | uniprot id | status |
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Abbexa | MYC | abx356386 | Chicken Myc Proto-Oncogene Protein (MYC) ELISA Kit | Chicken | Serum,Plasma,Other biological fluids | Sandwich | 1.56 ng/ml - 100 ng/ml | 0.94 ng/ml | 662.5 | 96 tests | RUO | |
Abbexa | MYC | abx516239 | Cow Myc proto-oncogene protein (MYC) ELISA Kit | Cow | Tissue homogenates,Cell lysates,Other biological fluids | 0.156 ng/ml - 10 ng/ml | 687.5 | 96 tests | Q2HJ27 | RUO | ||
Abbexa | MYC | abx516241 | Dog Myc proto-oncogene protein (MYC) ELISA Kit | Dog | Tissue homogenates,Cell lysates,Other biological fluids | 0.156 ng/ml - 10 ng/ml | 687.5 | 96 tests | Q28350 | RUO | ||
Abbexa | Myc | abx596625 | Myc (pS62) DNA-Binding ELISA Kit | Human | DNA Binding ELISA | 562.5 | 96 tests | P01106 | RUO | |||
Abbexa | Myc | abx596626 | Myc (pT58) DNA-Binding ELISA Kit | Human | DNA Binding ELISA | 562.5 | 96 tests | P01106 | RUO | |||
Abbexa | MYC | abx250744 | Human V-Myc Myelocytomatosis Viral Oncogene Homolog (MYC) ELISA Kit | Human | Serum,Plasma,Other biological fluids | Sandwich | 0.156 ng/ml - 10 ng/ml | 0.1 ng/ml | 562.5 | 96 tests | B3CJ74 | RUO |
Abbexa | MYC | abx197903 | Human V-Myc Myelocytomatosis Viral Oncogene Homolog (MYC) CLIA Kit | Human | Serum, plasma and other biological fluids. | Sandwich | 31.2 pg/ml - 2000 pg/ml | 18.8 pg/ml | 618.75 | 96 tests | RUO | |
Abbexa | MYC | abx252232 | Human Myc Proto-Oncogene Protein (MYC) ELISA Kit | Human | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 0.312 ng/ml - 20 ng/ml | 0.19 ng/ml | 525 | 96 tests | P01106 | RUO |
Abbexa | MYC | abx053112 | Human Myc Proto-Oncogene Protein (MYC) ELISA Kit | Human | Serum,Plasma,Other biological fluids | Sandwich | 0.04 ng/ml - 3 ng/ml | 0.03 ng/ml | 525 | 96 tests | RUO | |
Abbexa | MYC | abx152413 | Human V-Myc Myelocytomatosis Viral Oncogene Homolog (MYC) ELISA Kit | Human | Tissue homogenates,Other biological fluids | Sandwich | 1.56 ng/ml - 100 ng/ml | < 0.59 ng/ml | 662.5 | 96 tests | RUO | |
Abbexa | MYC | abx492598 | Human V-Myc Myelocytomatosis Viral Oncogene Homolog (MYC) CLIA Kit | Human | Tissue homogenates, cell lysates and other biological fluids. | Sandwich | 1.56 ng/ml - 100 ng/ml | < 0.59 ng/ml | 812.5 | 96 tests | RUO | |
Abbexa | MYC | abx596519 | Myc Proto-Oncogene Protein (MYC) DNA-Binding ELISA Kit | Human | DNA Binding ELISA | 537.5 | 96 tests | P01106 | RUO | |||
Abbexa | MYC | abx595412 | Myc Proto-Oncogene Protein (MYC) Cell ELISA Kit | Human | Cell ELISA | 493.75 | 96 tests | P01106 | RUO | |||
Abbexa | MYC | abx255274 | Mouse Myc Proto-Oncogene Protein (MYC) ELISA Kit | Mouse | Serum,Plasma,Other biological fluids | Sandwich | 15.63 pg/ml - 1000 pg/ml | 9.38 pg/ml | 525 | 96 tests | RUO | |
Abbexa | MYC | abx154421 | Mouse V-Myc Myelocytomatosis Viral Oncogene Homolog (MYC) ELISA Kit | Mouse | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 0.156 ng/ml - 10 ng/ml | < 0.07 ng/ml | 675 | 96 tests | RUO | |
Abbexa | MYC | abx492599 | Mouse V-Myc Myelocytomatosis Viral Oncogene Homolog (MYC) CLIA Kit | Mouse | Tissue homogenates, cell lysates and other biological fluids. | Sandwich | 0.156 ng/ml - 10 ng/ml | < 0.066 ng/ml | 812.5 | 96 tests | RUO | |
Abbexa | MYC | abx361060 | Pig Myc Proto-Oncogene Protein (MYC) ELISA Kit | Pig | Serum,Plasma,Other biological fluids | Sandwich | 0.312 ng/ml - 20 ng/ml | 0.19 ng/ml | 687.5 | 96 tests | RUO | |
Abbexa | MYC | abx256813 | Rat Myc Proto-Oncogene Protein (MYC) ELISA Kit | Rat | Serum,Plasma,Other biological fluids | Sandwich | 31.25 pg/ml - 2000 pg/ml | 18.75 pg/ml | 531.25 | 96 tests | RUO | |
Abbexa | MYC | abx155850 | Rat V-Myc Myelocytomatosis Viral Oncogene Homolog (MYC) ELISA Kit | Rat | Serum,Plasma,Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 0.156 ng/ml - 10 ng/ml | < 0.07 ng/ml | 687.5 | 96 tests | RUO | |
Abbexa | MYC | abx492600 | Rat V-Myc Myelocytomatosis Viral Oncogene Homolog (MYC) CLIA Kit | Rat | Serum, plasma, tissue homogenates, cell lysates and other biological fluids. | Sandwich | 0.156 ng/ml - 10 ng/ml | < 0.062 ng/ml | 812.5 | 96 tests | RUO |
provider | Code | reference | name | reactivity | clonality | host | immunogen target | isotype | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | Myc | abx137181 | Myc Proto-Oncogene Protein (Myc) Antibody | Polyclonal | Rabbit | Myc Proto-Oncogene Protein (Myc) | Unconjugated | 525 | 100 µl | RUO | ||||
Abbexa | Myc | abx137110 | V-Myc Myelocytomatosis Viral Oncogene Homolog (Myc) Antibody | Monoclonal | Mouse | V-Myc Myelocytomatosis Viral Oncogene Homolog (Myc) | Unconjugated | 337.5 | 100 µg | RUO | ||||
Abbexa | Myc | abx130438 | c-Myc Epitope (Myc) Antibody | General | Monoclonal | Mouse | c-Myc Epitope (Myc) | Unconjugated | WB, DB | 850 | 1 ml | RUO | ||
Abbexa | Myc | abx132269 | c-Myc Epitope (Myc) Antibody | General | Polyclonal | Rabbit | c-Myc Epitope (Myc) | Unconjugated | WB, DB | 850 | 1 ml | RUO | ||
Abbexa | MYC | abx210096 | V-Myc Myelocytomatosis Viral Oncogene Homolog (MYC) Antibody | General | Monoclonal | Mouse | V-Myc Myelocytomatosis Viral Oncogene Homolog (MYC) | Unconjugated | ELISA, WB, IF/ICC, IP | 212.5 | 50 µg | RUO | ||
Abbexa | MYC | abx139769 | Myc Proto-Oncogene Protein (MYC) Antibody (FITC) | General | Monoclonal | Mouse | Myc Proto-Oncogene Protein (MYC) | FITC | FCM | 400 | 0.1 mg | P01106 | RUO | |
Abbexa | MYC | abx139768 | Myc Proto-Oncogene Protein (MYC) Antibody (Biotin) | General | Monoclonal | Mouse | Myc Proto-Oncogene Protein (MYC) | Biotin | WB, IHC-P, FCM, IP | 400 | 0.1 mg | P01106 | RUO | |
Abbexa | MYC | abx139767 | Myc Proto-Oncogene Protein (MYC) Antibody (HRP) | General | Monoclonal | Mouse | Myc Proto-Oncogene Protein (MYC) | HRP | WB | 487.5 | 0.1 mg | P01106 | RUO | |
Abbexa | MYC | abx402479 | Myc proto-oncogene protein (MYC) Antibody | Human | Monoclonal | Rabbit | Myc proto-oncogene protein (MYC) | Unconjugated | ELISA, FCM | 287.5 | 50 µl | P01106 | RUO | |
Abbexa | MYC | abx031253 | Myc Proto-Oncogene Protein (MYC) Antibody | Human | Polyclonal | Rabbit | Myc Proto-Oncogene Protein (MYC) | Unconjugated | ELISA, WB, IHC | 250 | 80 µl | P01106 | RUO | |
Abbexa | MYC | abx011838 | Myc Proto-Oncogene Protein (MYC) Antibody | Human | Monoclonal | Mouse | Myc Proto-Oncogene Protein (MYC) | Unconjugated | ELISA | 362.5 | 100 µl | P01106 | RUO | |
Abbexa | MYC | abx031252 | Myc Proto-Oncogene Protein (MYC) Antibody | Human | Polyclonal | Rabbit | Myc Proto-Oncogene Protein (MYC) | Unconjugated | ELISA, WB, FCM | 250 | 80 µl | P01106 | RUO | |
Abbexa | MYC | abx137743 | Myc Proto-Oncogene Protein (MYC) Antibody | Human | Monoclonal | Mouse | Myc Proto-Oncogene Protein (MYC) | 225 | 5 µg | RUO | ||||
Abbexa | MYC | abx175111 | V-Myc Myelocytomatosis Viral Oncogene Homolog (MYC) Antibody | Human | Monoclonal | Mouse | V-Myc Myelocytomatosis Viral Oncogene Homolog (MYC) | Unconjugated | WB, IHC, IF/ICC | 750 | 1 ml | RUO | ||
Abbexa | MYC | abx323248 | Myc Proto-Oncogene Protein (MYC) Antibody | Human | Polyclonal | Rabbit | Myc Proto-Oncogene Protein (MYC) | Unconjugated | WB | 187.5 | 50 µg | P01106 | RUO | |
Abbexa | MYC | abx341058 | Myc Proto-Oncogene Protein (MYC) Antibody | Human | Monoclonal | Mouse | Myc Proto-Oncogene Protein (MYC) | Unconjugated | ELISA, WB | 287.5 | 50 µl | P01106 | RUO | |
Abbexa | MYC | abx104353 | V-Myc Myelocytomatosis Viral Oncogene Homolog (MYC) Antibody | Human | Polyclonal | Rabbit | V-Myc Myelocytomatosis Viral Oncogene Homolog (MYC) | Unconjugated | WB, IHC, IF/ICC | 262.5 | 100 µl | P01106 | RUO | |
Abbexa | MYC | abx318489 | Myc Proto-Oncogene Protein (MYC) Antibody | Human | Polyclonal | Rabbit | Myc Proto-Oncogene Protein (MYC) | Unconjugated | ELISA, WB, IHC | 162.5 | 20 µg | P01106 | RUO | |
Abbexa | MYC | abx123800 | V-Myc Myelocytomatosis Viral Oncogene Homolog (MYC) Antibody | Human | Polyclonal | Rabbit | V-Myc Myelocytomatosis Viral Oncogene Homolog (MYC) | Unconjugated | WB | 175 | 20 µl | P01106 | RUO | |
Abbexa | MYC | abx328462 | Myc Proto-Oncogene Protein (MYC) Antibody | Human | Polyclonal | Rabbit | Myc Proto-Oncogene Protein (MYC) | Unconjugated | ELISA, WB, IHC | 187.5 | 50 µg | P01106 | RUO | |
Abbexa | MYC | abx116626 | Myc Proto-Oncogene Protein (MYC) Antibody | Human | Polyclonal | Rabbit | Myc Proto-Oncogene Protein (MYC) | Unconjugated | ELISA, WB, IHC, IF/ICC, FCM, IP | 612.5 | 100 µl | P01106 | RUO | |
Abbexa | MYC | abx013356 | Myc Proto-Oncogene Protein (MYC) Antibody | Human | Polyclonal | Rabbit | Myc Proto-Oncogene Protein (MYC) | Unconjugated | WB, IHC | 43.75 | 10 µg | P01106 | RUO | |
Abbexa | MYC | abx011213 | Myc Proto-Oncogene Protein (MYC) Antibody | Human | Polyclonal | Rabbit | Myc Proto-Oncogene Protein (MYC) | Unconjugated | ELISA, WB | 350 | 100 µg | P01106 | RUO | |
Abbexa | MYC | abx242461 | Myc Proto-Oncogene Protein (MYC) Antibody | Human | Polyclonal | Rabbit | Myc Proto-Oncogene Protein (MYC) | Unconjugated | ELISA, WB, IHC | 250 | 50 µl | P01106 | RUO | |
Abbexa | MYC | abx343918 | Myc Proto-Oncogene Protein (MYC) Antibody (Biotin) | Mouse | Polyclonal | Rabbit | Myc Proto-Oncogene Protein (MYC) | Biotin | ELISA | 162.5 | 20 µg | P01108 | RUO | |
Abbexa | MYC | abx343915 | Myc Proto-Oncogene Protein (MYC) Antibody | Mouse | Polyclonal | Rabbit | Myc Proto-Oncogene Protein (MYC) | Unconjugated | ELISA | 162.5 | 20 µg | P01108 | RUO | |
Abbexa | MYC | abx343916 | Myc Proto-Oncogene Protein (MYC) Antibody (HRP) | Mouse | Polyclonal | Rabbit | Myc Proto-Oncogene Protein (MYC) | HRP | ELISA | 162.5 | 20 µg | P01108 | RUO | |
Abbexa | MYC | abx343917 | Myc Proto-Oncogene Protein (MYC) Antibody (FITC) | Mouse | Polyclonal | Rabbit | Myc Proto-Oncogene Protein (MYC) | FITC | 162.5 | 20 µg | P01108 | RUO | ||
Abbexa | MYC | abx104354 | V-Myc Myelocytomatosis Viral Oncogene Homolog (MYC) Antibody | Mouse | Polyclonal | Rabbit | V-Myc Myelocytomatosis Viral Oncogene Homolog (MYC) | Unconjugated | WB, IHC, IF/ICC | 262.5 | 100 µl | P01108 | RUO | |
Abbexa | MYC | abx126207 | Myc Proto-Oncogene Protein (MYC) Antibody | Mouse | Polyclonal | Rabbit | Myc Proto-Oncogene Protein (MYC) | Unconjugated | IHC | 175 | 20 µl | P01106 | RUO | |
Abbexa | MYC | abx018375 | V-Myc Myelocytomatosis Viral Oncogene Homolog (MYC) Antibody | Plant | Polyclonal | Rabbit | V-Myc Myelocytomatosis Viral Oncogene Homolog (MYC) | Unconjugated | 300 | 100 µl | RUO |
provider | Code | reference | name | origin | expression | host | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | MYC | abx651464 | Human V-Myc Myelocytomatosis Viral Oncogene Homolog (MYC) Protein (Active) | Human | Unconjugated | WB, SDS-PAGE | 637.5 | 50 µg | P01106 | RUO | ||
Abbexa | MYC | abx069686 | Mouse V-Myc Myelocytomatosis Viral Oncogene Homolog (MYC) Protein | Mouse | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 225 | 10 µg | P01108 | RUO |
Abbexa | MYC | abx069685 | Human V-Myc Myelocytomatosis Viral Oncogene Homolog (MYC) Protein | Human | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 225 | 10 µg | P01106 | RUO |
Abbexa | MYC | abx655499 | Rat V-Myc Myelocytomatosis Viral Oncogene Homolog (MYC) Protein | Rat | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 1800 | 1 mg | RUO |
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